(Q36472094)

English

Phase 2, randomised placebo-controlled trial to evaluate the efficacy and safety of an anti-GM-CSF antibody (KB003) in patients with inadequately controlled asthma

scientific article

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scholarly article

1 reference

Europe PubMed Central

14 August 2017

Phase 2, randomised placebo-controlled trial to evaluate the efficacy and safety of an anti-GM-CSF antibody (KB003) in patients with inadequately controlled asthma (English)

1 reference

Europe PubMed Central

14 August 2017

phase II clinical trial

0 references

0 references

0 references

placebo-controlled trial

1 reference

based on heuristic

inferred from title

2

object named as

Piotr Kuna

1 reference

Europe PubMed Central

14 August 2017

author name string

Nestor A Molfino

1

1 reference

Europe PubMed Central

14 August 2017

Jonathan A Leff

3

1 reference

Europe PubMed Central

14 August 2017

Chad K Oh

4

1 reference

Europe PubMed Central

14 August 2017

Dave Singh

5

1 reference

Europe PubMed Central

14 August 2017

Marlene Chernow

6

1 reference

Europe PubMed Central

14 August 2017

Brian Sutton

7

1 reference

Europe PubMed Central

14 August 2017

Geoffrey Yarranton

8

1 reference

Europe PubMed Central

14 August 2017

publication date

6 January 2016

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

6

1 reference

Europe PubMed Central

14 August 2017

1

1 reference

Europe PubMed Central

14 August 2017

e007709

1 reference

Europe PubMed Central

14 August 2017

Th17-mediated inflammation in asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

30 September 2017

Asthma outcomes: healthcare utilization and costs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

30 September 2017

Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

30 September 2017

Reslizumab for Poorly Controlled, Eosinophilic Asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

30 September 2017

Priming of eosinophils by GM-CSF is mediated by protein kinase CbetaII-phosphorylated L-plastin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

30 September 2017

Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

30 September 2017

Role of IL-23-Th17 cell axis in allergic airway inflammation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

30 September 2017

Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

30 September 2017

Granulocyte-macrophage colony-stimulating factor expression in induced sputum and bronchial mucosa in asthma and COPD

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

30 September 2017

Innate immune activation in neutrophilic asthma and bronchiectasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

30 September 2017

GM-CSF in inflammation and autoimmunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

30 September 2017

Non-eosinophilic asthma: importance and possible mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

30 September 2017

Diesel exhaust particulate induces airway hyperresponsiveness in a murine model: essential role of GM-CSF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

30 September 2017

Endobronchial allergen challenge in asthma. Demonstration of cellular source of granulocyte macrophage colony-stimulating factor by in situ hybridization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

30 September 2017

Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

28 June 2018

IL-2 and IL-4 counteract budesonide inhibition of GM-CSF and IL-10, but not of IL-8, IL-12 or TNF-alpha production by human mononuclear blood cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

28 June 2018

Expression of the Potent Inflammatory Cytokines, GM-CSF, IL6, and IL8, in Bronchial Epithelial Cells of Asthmatic Patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

28 June 2018

Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

21 September 2018

Mepolizumab treatment in patients with severe eosinophilic asthma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

21 September 2018

Systemic upregulation of neutrophil α-defensins and serine proteases in neutrophilic asthma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

21 September 2018

Mepolizumab for prednisone-dependent asthma with sputum eosinophilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

21 September 2018

Osteoclastic potential of human CFU-GM: biphasic effect of GM-CSF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

21 September 2018

A role of GM-CSF in the accumulation of neutrophils in the airways caused by IL-17 and TNF-alpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

21 September 2018

Attenuation of airway hyperresponsiveness in a murine asthma model by neutralization of granulocyte-macrophage colony-stimulating factor (GM-CSF).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

21 September 2018

Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

21 September 2018

Development and validation of a questionnaire to measure asthma control.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

21 September 2018

Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716197

21 September 2018

Natural and Therapy-Induced Anti-GM-CSF and Anti-G-CSF Antibodies in Human Serum

1 reference

https://api.crossref.org/works/10.1136%2FBMJOPEN-2015-007709

21 January 2018

Surfactant proteins in pulmonary alveolar proteinosis in adults

1 reference

https://pubmed.ncbi.nlm.nih.gov/26739717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A bronchial epithelial cell-derived factor in asthma that promotes eosinophil activation and survival as GM-CSF

1 reference

https://pubmed.ncbi.nlm.nih.gov/26739717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Granulocyte-macrophage colony-stimulating factor, eosinophils and eosinophil cationic protein in subjects with and without mild, stable, atopic asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26739717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pulmonary surfactant protein D in sera and bronchoalveolar lavage fluids

1 reference

https://pubmed.ncbi.nlm.nih.gov/26739717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of αGM-CSF-receptor in nonatopic asthma but not in atopic asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26739717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody to granulocyte-macrophage colony-stimulating factor is a dominant anti-cytokine activity in human IgG preparations

1 reference

https://pubmed.ncbi.nlm.nih.gov/26739717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eosinophils do not enhance the trans-basement-membrane migration of neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/26739717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized, double-blind, placebo-controlled study of tumor necrosis factor-α blockade in severe persistent asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26739717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of asthma according to blood inflammatory patterns

1 reference

https://pubmed.ncbi.nlm.nih.gov/26739717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26739717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutralizing Granulocyte/Macrophage Colony–Stimulating Factor Inhibits Cigarette Smoke–induced Lung Inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26739717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Granulocyte macrophage-colony-stimulating factor mRNA is stabilized in airway eosinophils and peripheral blood eosinophils activated by TNF-alpha plus fibronectin

1 reference

https://pubmed.ncbi.nlm.nih.gov/26739717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced eosinophil apoptosis in induced sputum correlates with asthma severity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26739717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1136/BMJOPEN-2015-007709

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

ResearchGate publication ID

0 references

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