(Q37957225)

25 August 2017

title

Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor (English)

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25 August 2017

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N A Molfino

1

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25 August 2017

D Gossage

2

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25 August 2017

R Kolbeck

3

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25 August 2017

J M Parker

4

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25 August 2017

G P Geba

5

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25 August 2017

publication date

23 September 2011

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Clinical & Experimental Allergy

25 August 2017

published in

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25 August 2017

volume

42

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25 August 2017

issue

5

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25 August 2017

page(s)

712-737

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T-cell co-stimulatory molecules: novel targets for the treatment of allergic airway disease

25 August 2017

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High-resolution tracking of cell division demonstrates differential effects of TH1 and TH2 cytokines on SCF-dependent human mast cell production in vitro: correlation with apoptosis and Kit expression

21 January 2018

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A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5

21 January 2018

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Creation of a biologically active interleukin-5 monomer

21 January 2018

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IL-5-mediated eosinophil survival requires inhibition of GSK-3 and correlates with β-catenin relocalization.

21 January 2018

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IL-3, IL-5, and GM-CSF signaling: crystal structure of the human beta-common receptor

21 January 2018

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Autonomic innervation of human airways: structure, function, and pathophysiology in asthma

21 January 2018

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Interleukin-5 receptor subunit oligomerization and rearrangement revealed by fluorescence resonance energy transfer imaging

21 January 2018

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Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.

21 January 2018

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Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses

21 January 2018

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Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion

21 January 2018

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Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation

21 January 2018

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Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion

21 January 2018

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Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects.

21 January 2018

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Basophils express a type 2 cytokine profile on exposure to proteases from helminths and house dust mites

21 January 2018

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Airway allergen exposure stimulates bone marrow eosinophilia partly via IL-9.

21 January 2018

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Regulation of bone marrow and airway CD34+ eosinophils by interleukin-5.

21 January 2018

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Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation

21 January 2018

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Allergen-induced increases in bone marrow T lymphocytes and interleukin-5 expression in subjects with asthma.

21 January 2018

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Interactions between eotaxin, histamine and mast cells in early microvascular events associated with eosinophil recruitment to the site of allergic skin reactions in humans

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Ligand density modulates eosinophil signaling and migration

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Sputum CD34+IL-5Ralpha+ cells increase after allergen: evidence for in situ eosinophilopoiesis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Eosinophil progenitors in allergy and asthma - do they matter?

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

New production of eosinophils and the corresponding TH1/TH2 balance in the lungs after allergen exposure in BALB/c and C57BL/6 mice.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Bone marrow events in animal models of allergic inflammation and hyperresponsiveness

21 January 2018

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Local proliferation and mobilization of CCR3(+) CD34(+) eosinophil-lineage-committed cells in the lung

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

IgE influences the number and function of mature mast cells, but not progenitor recruitment in allergic pulmonary inflammation

21 January 2018

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The phenotype of human eosinophils, basophils, and mast cells.

21 January 2018

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Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists

21 January 2018

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Human mast cells express receptors for IL-3, IL-5 and GM-CSF; a partial map of receptors on human mast cells cultured in vitro

21 January 2018

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Structure-based rationale for interleukin 5 receptor antagonism

21 January 2018

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Kinetic interaction analysis of human interleukin 5 receptor alpha mutants reveals a unique binding topology and charge distribution for cytokine recognition.

21 January 2018

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Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Structural design and molecular evolution of a cytokine receptor superfamily

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Multimeric cytokine receptors: common versus specific functions

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Biosensor analysis of dynamics of interleukin 5 receptor subunit beta(c) interaction with IL5:IL5R(alpha) complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Receptor epitope usage by an interleukin-5 mimetic peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Asymmetric usage of antagonist charged residues drives interleukin-5 receptor recruitment but is insufficient for receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

The activation of the JAK2/STAT5 pathway is commonly involved in signaling through the human IL-5 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Interleukin-3, -5, and granulocyte macrophage colony-stimulating factor induce adhesion and chemotaxis of human eosinophils via p38 mitogen-activated protein kinase and nuclear factor kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Intracellular JNK, p38 MAPK and NF-kappaB regulate IL-25 induced release of cytokines and chemokines from costimulated T helper lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Interleukin-3, -5, and granulocyte macrophage colony-stimulating factor-induced adhesion molecule expression on eosinophils by p38 mitogen-activated protein kinase and nuclear factor-[kappa] B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

The adenylyl cyclase-cAMP system suppresses TARC/CCL17 and MDC/CCL22 production through p38 MAPK and NF-kappaB in HaCaT keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Fluvastatin inhibits expression of the chemokine MDC/CCL22 induced by interferon-gamma in HaCaT cells, a human keratinocyte cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Biochemical assessment of intracellular signal transduction pathways in eosinophils: implications for pharmacotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

IL-5-Induced JAB-JAK2 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

21 January 2018

IL-5 and eosinophilia.

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

IL-5- and eosinophil-mediated inflammation: from discovery to therapy

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Differential regulation of interleukin 5-stimulated signaling pathways by dynamin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Regulation of interleukin-5-induced beta2-integrin adhesion of human eosinophils by phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Identification of eosinophil lineage-committed progenitors in the murine bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

In vitro effects of budesonide on eosinophil-basophil lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines, and adhesion receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

T cell-dependent regulation of eotaxin in antigen-induced pulmonary eosinophila

21 January 2018

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Regulation of Eosinophil Migration and Th2 Cell Function by IL-5 and Eotaxin

21 January 2018

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Basic pathogenesis of eosinophilic esophagitis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Increased expression of eotaxin-3 distinguishes between eosinophilic esophagitis and gastroesophageal reflux disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

The role of IL-5 for mature B-1 cells in homeostatic proliferation, cell survival, and Ig production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Inhibition of airway remodeling in IL-5-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Effect of anti-IL-5 and IL-5 on airway hyperreactivity and eosinophils in guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Antibody against interleukin-5 prevents antigen-induced eosinophil infiltration and bronchial hyperreactivity in the guinea pig airways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Defining a link with asthma in mice congenitally deficient in eosinophils.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

A critical role for eosinophils in allergic airways remodeling

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Epidemiologic, experimental, and clinical links between respiratory syncytial virus infection and asthma

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Of mice and not men: differences between mouse and human immunology

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Eosinophil degranulation: an evolutionary vestige or a universally destructive effector function?

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

The eosinophil ribonucleases.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Molecular cloning and expression of the human interleukin 5 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Eosinophils in health and disease: the LIAR hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Corticosteroids, eosinophils and bronchial epithelial cells: new insights into the resolution of inflammation in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Tissue and BAL based biomarkers in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Eosinophil trafficking in allergy and asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Association of interleukin-5 and eotaxin with acute exacerbation of asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Anti-interleukin-5 monoclonal antibodies: preclinical and clinical evidence in asthma models

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

How epidemiology has challenged 3 prevailing concepts about atopic dermatitis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Blood eosinophilia in atopic dermatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

In vivo expression of cytokine receptor mRNA in atopic dermatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

11. Allergic and immunologic diseases of the skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Efficacy of omalizumab in the treatment of atopic dermatitis: a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Immunological and clinical changes in allergic asthmatics following treatment with omalizumab

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Effect of omalizumab treatment on peripheral eosinophil and T-lymphocyte function in patients with allergic asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Eosinophilic bronchitis: clinical manifestations and implications for treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Chronic bronchitis sub-phenotype within COPD: inflammation in sputum and biopsies.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Exacerbations of Bronchitis: bronchial eosinophilia and gene expression for interleukin-4, interleukin-5, and eosinophil chemoattractants.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Plasma cells and IL-4 in chronic bronchitis and chronic obstructive pulmonary disease

21 January 2018

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Allergy and eosinophil-associated gastrointestinal disorders (EGID).

21 January 2018

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Cytokine expression in normal and inflamed esophageal mucosa: a study into the pathogenesis of allergic eosinophilic esophagitis.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Treatment with topical steroids downregulates IL-5, eotaxin-1/CCL11, and eotaxin-3/CCL26 gene expression in eosinophilic esophagitis.

21 January 2018

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Eosinophilic esophagitis: updated consensus recommendations for children and adults

21 January 2018

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The hypereosinophilic syndromes: current concepts and treatments

21 January 2018

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A critical appraisal of conventional and investigational drug therapy in patients with hypereosinophilic syndrome and clonal eosinophilia

21 January 2018

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Modern diagnosis and treatment of primary eosinophilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Hypereosinophilic syndrome: diagnosis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Lymphocytic variant hypereosinophilic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Brief report: clonal proliferation of type 2 helper T cells in a man with the hypereosinophilic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Mepolizumab as a corticosteroid-sparing agent in lymphocytic variant hypereosinophilic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Proinflammatory cytokines and autoimmunity in Churg-Strauss syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Differential expression of the interleukin 5 receptor alpha isoforms in blood and tissue eosinophils of nasal polyp patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Mepolizumab and eosinophil-mediated disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Mepolizumab and exacerbations of refractory eosinophilic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-β1, and increase esophageal smooth muscle contraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Monoclonal anti-interleukin-5 treatment suppresses eosinophil but not T-cell functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Mepolizumab for prednisone-dependent asthma with sputum eosinophilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Anti–IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Mepolizumab in refractory eosinophilic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Enhanced soluble interleukin-5 receptor alpha expression in nasal polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Safety and efficacy of the monoclonal anti-interleukin-5 antibody SCH55700 in the treatment of patients with hypereosinophilic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Immunomodulatory therapy of eosinophil-associated gastrointestinal diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Small interfering RNA against interleukin-5 decreases airway eosinophilia and hyper-responsiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Eosinophils in innate immunity: an evolving story

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

Hypereosinophilic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2011.03854.X

10.1111/J.1365-2222.2011.03854.X

21 January 2018

Identifiers

DOI

1 reference

release_azctogd2s5gidmsmvnodvgxtga

25 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/azctogd2s5gidmsmvnodvgxtga

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference