(Q36488794)

14 August 2017

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title

Protease pathways in peptide neurotransmission and neurodegenerative diseases (English)

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14 August 2017

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Vivian Y H Hook

1

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14 August 2017

25 May 2006

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Cellular and Molecular Neurobiology

14 August 2017

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14 August 2017

26

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14 August 2017

4-6

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14 August 2017

449-469

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https://scigraph.springernature.com/pub.10.1007/s10571-006-9047-7

14 August 2017

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cites work

Identification of the sorting signal motif within pro-opiomelanocortin for the regulated secretory pathway

1 reference

https://api.crossref.org/works/10.1007%2FS10571-006-9047-7

The toxicity in vitro of beta-amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-006-9047-7

Homozygotes and heterozygotes for ciliary neurotrophic factor null alleles do not show earlier onset of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-006-9047-7

Precursor convertases in the secretory pathway, cytosol and extracellular milieu

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-006-9047-7

Lysosomal cysteine proteases: more than scavengers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-006-9047-7

Binding mode of CA074, a specific irreversible inhibitor, to bovine cathepsin B as determined by X-ray crystal analysis of the complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10571-006-9047-7

The role of neuropeptide Y in cardiovascular regulation

21 January 2018

1 reference

12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

12 December 2020

Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease

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12 December 2020

Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.

1 reference

12 December 2020

The role of NPY in metabolic homeostasis: implications for obesity therapy

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12 December 2020

Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons

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12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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12 December 2020

Endogenous opiates and behavior: 2004.

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12 December 2020

Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones

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12 December 2020

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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12 December 2020

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices

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12 December 2020

Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

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12 December 2020

Cutting back on pro-protein convertases: the latest approaches to pharmacological inhibition

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12 December 2020

The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugs.

1 reference

12 December 2020

Transgenic models of Huntington's disease

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12 December 2020

Role of pituitary POMC-peptides and insulin-like growth factor II in the developmental biology of the adrenal gland

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12 December 2020

Angiotensin-converting enzyme inhibitors and angiotensin II type I receptor blockers in the management of congestive heart failure patients: what have we learned from recent clinical trials?

1 reference

12 December 2020

Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study

1 reference

12 December 2020

Altered processing of pro-orphanin FQ/nociceptin and pro-opiomelanocortin-derived peptides in the brains of mice expressing defective prohormone convertase 2.

1 reference

12 December 2020

The proprotein convertases

1 reference

12 December 2020

Atazanavir: a new protease inhibitor to treat HIV infection

1 reference

12 December 2020

Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.

1 reference

12 December 2020

Potential Use of Estrogen-Like Drugs for the Prevention of Alzheimer's Disease

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12 December 2020

Corticotropin-releasing hormone modulators and depression

1 reference

12 December 2020

Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease.

1 reference

12 December 2020

Regulated secretion of beta-amyloid precursor protein in rat brain

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12 December 2020

Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these struc

1 reference

12 December 2020

Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells

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12 December 2020

Proteolytic processing in the secretory pathway

1 reference

12 December 2020

Alzheimer's disease: perspectives for the new millennium

1 reference

12 December 2020

Regulation of amyloid beta-peptide levels by enzymatic degradation.

1 reference

12 December 2020

CA074 methyl ester: a proinhibitor for intracellular cathepsin B

1 reference

12 December 2020

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

1 reference

12 December 2020

Amyloid-beta metal interaction and metal chelation.

1 reference

12 December 2020

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

12 December 2020

Secretory granule biogenesis and neuropeptide sorting to the regulated secretory pathway in neuroendocrine cells

1 reference

12 December 2020

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

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12 December 2020

Statins as potential therapeutic agents in neuroinflammatory disorders

1 reference

12 December 2020

Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice

1 reference

12 December 2020

Regulation of opioid receptor activities

1 reference

12 December 2020

Evidence for the proenkephalin processing enzyme prohormone thiol protease (PTP) as a multicatalytic cysteine protease complex: activation by glutathione localized to secretory vesicles

1 reference

12 December 2020

Angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers for prevention and treatment of nephropathy associated with type 2 diabetes mellitus

1 reference

12 December 2020

Regulated and constitutive secretion. Differential effects of protein synthesis arrest on transport of glycosaminoglycan chains to the two secretory pathways

1 reference

12 December 2020

Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development.

1 reference

12 December 2020

Central control of feeding behavior by neuropeptide Y.

1 reference

12 December 2020

1 reference

12 December 2020

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

1 reference

12 December 2020

Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells

1 reference

12 December 2020

Selective roles for the PC2 processing enzyme in the regulation of peptide neurotransmitter levels in brain and peripheral neuroendocrine tissues of PC2 deficient mice

1 reference

12 December 2020

The molecular basis of memantine action in Alzheimer's disease and other neurologic disorders: low-affinity, uncompetitive antagonism

1 reference

12 December 2020

Neuropeptide processing profile in mice lacking prohormone convertase-1.

1 reference

12 December 2020

Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes

1 reference

12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

12 December 2020

Pharmacotherapy review: angiotensin-converting enzyme inhibitors

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12 December 2020

Processing and activation of lysosomal proteinases

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12 December 2020

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12 December 2020

Two distinct intracellular pathways transport secretory and membrane glycoproteins to the surface of pituitary tumor cells

1 reference

12 December 2020

The Therapeutic Potential of Neuropeptide Y : Analgesic, Anxiolytic and Antihypertensive

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

1 reference

12 December 2020

Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.

1 reference

12 December 2020

Central stimulation-induced analgesia in humans--modulation by endogenous opioid peptides.

1 reference

12 December 2020

Defective prodynorphin processing in mice lacking prohormone convertase PC2.

1 reference

12 December 2020

Galanin and spatial learning in the rat. Evidence for a differential role for galanin in subregions of the hippocampal formation.

1 reference

12 December 2020

Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum.

1 reference

12 December 2020

Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders

1 reference

12 December 2020

Full-length and truncated Alzheimer amyloid precursors in chromaffin granules: solubilization of membrane amyloid precursor is mediated by an enzymatic mechanism.

1 reference

12 December 2020

Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles

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12 December 2020

Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1.

1 reference

12 December 2020

Peptidomimetic inhibitors of HIV protease

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12 December 2020

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

1 reference

12 December 2020

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12 December 2020

Proteases and the emerging role of protease inhibitors in prohormone processing.

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12 December 2020

Cysteine proteases are the major β‐secretase in the regulated secretory pathway that provides most of the β‐amyloid in Alzheimer's disease: Role of BACE 1 in the constitutive secretory pathway

1 reference

12 December 2020

Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.

1 reference

12 December 2020

Updated clinical pharmacologic considerations for HIV-1 protease inhibitors

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12 December 2020

Neuropeptides and obesity

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12 December 2020

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

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12 December 2020

Hypothalamic-pituitary-adrenocortical axis regulation

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12 December 2020

Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease

1 reference

12 December 2020

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

12 December 2020

1 reference

12 December 2020

Structural basis of inhibition of cysteine proteases by E-64 and its derivatives

1 reference

12 December 2020

"Prohormone thiol protease" (PTP) processing of recombinant proenkephalin

1 reference

12 December 2020

Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

1 reference

12 December 2020

10.1007/S10571-006-9047-7

Identifiers

DOI

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14 August 2017

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PubMed ID

16724274