(Q36490192)

14 August 2017

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title

Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities (English)

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14 August 2017

Reed JC

1

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14 August 2017

language of work or name

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2 June 2006

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Cell Death & Differentiation

14 August 2017

published in

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14 August 2017

volume

13

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14 August 2017

issue

8

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14 August 2017

page(s)

1378-1386

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

14 August 2017

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

21 January 2018

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BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

21 January 2018

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

21 January 2018

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The role of BH3-only proteins in the immune system

21 January 2018

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Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

21 January 2018

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Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax.

21 January 2018

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Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe

21 January 2018

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Mammalian Bax-induced plant cell death can be down-regulated by overexpression of Arabidopsis Bax Inhibitor-1 (AtBI-1)

21 January 2018

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BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

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Structure of Bax: coregulation of dimer formation and intracellular localization

21 January 2018

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Solution structure of BID, an intracellular amplifier of apoptotic signaling

21 January 2018

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Bax-deficient mice with lymphoid hyperplasia and male germ cell death

21 January 2018

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Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage

21 January 2018

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BAX is required for neuronal death after trophic factor deprivation and during development

21 January 2018

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

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p53 induction is associated with neuronal damage in the central nervous system

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Immunohistochemical detection of Bax and Bcl-2 proteins in gerbil hippocampus following transient forebrain ischemia.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Expression of Bcl-2 family member Bid in normal and malignant tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation.

21 January 2018

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Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Increase in bax expression in substantia nigra following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment of mice.

21 January 2018

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Expression pattern of candidate cell death effector proteins Bax, Bcl-2, Bcl-X, and c-Jun in sensory and motor neurons following sciatic nerve transection in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Murine ovarian development is not affected by inactivation of the bcl-2 family member diva

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Characterization of NR13-related human cell death regulator, Boo/Diva, in normal and cancer tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Deficiency of Bax and Bak protects photoreceptors from light damage in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Breaking the mitochondrial barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

The Mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

The mitochondrial permeability transition from in vitro artifact to disease target

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Cell biology. Apoptosis--the calcium connection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Bcl-2 and Bax exert opposing effects on Ca2+ signaling, which do not depend on their putative pore-forming region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Modulation of endoplasmic reticulum calcium pump by Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Movement of Bax from the cytosol to mitochondria during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Conformation of the Bax C-terminus regulates subcellular location and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

BCL-2 family members and the mitochondria in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

BID: a novel BH3 domain-only death agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Conversion of Bcl-2 to a Bax-like death effector by caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Cell death: critical control points

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Ku70 suppresses the apoptotic translocation of Bax to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Epigenetic therapy of cancer: past, present and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Humanin peptide suppresses apoptosis by interfering with Bax activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

VDAC2 inhibits BAK activation and mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Bax-dependent regulation of Bak by voltage-dependent anion channel 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Chemotherapy: targeting the mitochondrial cell death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Cell death regulation by the Bcl-2 protein family in the mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Bid, but not Bax, regulates VDAC channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Oligomeric states of the voltage-dependent anion channel and cytochrome c release from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Apoptosis-based therapies for hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Pro-apoptotic treatment with an adenovirus encoding Bax enhances the effect of chemotherapy in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

3,6-Dibromocarbazole Piperazine Derivatives of 2-Propanol as First Inhibitors of Cytochrome c Release via Bax Channel Modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Expression of pro- and anti-apoptosis gene products in brains from paediatric patients with HIV-1 encephalitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

Widespread elimination of naturally occurring neuronal death in Bax-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

7 January 2021

Photochemical brain injury in rats triggers DNA fragmentation, p53 and HSP72

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

7 January 2021

Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

7 January 2021

The role of free radicals and p53 in neuron apoptosis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

7 January 2021

Upregulation of bax protein levels in neurons following cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

7 January 2021

BAX contributes to apoptotic-like death following neonatal hypoxia-ischemia: evidence for distinct apoptosis pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

7 January 2021

Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

7 January 2021

Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

7 January 2021

Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

7 January 2021

Remodeling for Demolition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

7 January 2021

Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401975

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401975

1 reference

14 August 2017

1 reference