(Q36497139)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

title

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

16

Bruce J Aronow

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

17

Timothy P Cripe

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

author name string

Shyra J Miller

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Edwin Jousma

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Jianqiang Wu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Tilat A Rizvi

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Meghan E Brundage

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

David Eaves

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Brigitte Widemann

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Mi-Ok Kim

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Eva Dombi

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Jessica Sabo

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Atira Hardiman Dudley

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Michiko Niwa-Kawakita

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Grier P Page

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Marco Giovannini

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Nancy Ratner

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

language of work or name

English

0 references

publication date

10 December 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Investigation

19 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

volume

123

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

page(s)

340-347

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

19 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3533264/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Ras-driven transcriptome analysis identifies aurora kinase A as a potential malignant peripheral nerve sheath tumor therapeutic target

30 September 2017

1 reference

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Therapeutic strategies for targeting ras proteins

30 September 2017

1 reference

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Integrated genomic analyses of ovarian carcinoma

30 September 2017

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Compensatory pathways induced by MEK inhibition are effective drug targets for combination therapy against castration-resistant prostate cancer

30 September 2017

1 reference

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Ras history: The saga continues

30 September 2017

1 reference

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Correlation of somatic mutation and expression identifies genes important in human glioblastoma progression and survival

30 September 2017

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Pilot study of PD-0325901 in previously treated patients with advanced melanoma, breast cancer, and colon cancer

30 September 2017

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Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies

30 September 2017

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A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice

30 September 2017

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Preclincial testing of sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging

30 September 2017

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Phase I trial of pegylated interferon-alpha-2b in young patients with plexiform neurofibromas

30 September 2017

1 reference

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Statistical issues in longitudinal data analysis for treatment efficacy studies in the biomedical sciences

30 September 2017

1 reference

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A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non-small cell lung cancer

30 September 2017

1 reference

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Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene

30 September 2017

1 reference

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Malignant peripheral nerve sheath tumour (MPNST): the clinical implications of cellular signalling pathways

30 September 2017

1 reference

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Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

30 September 2017

1 reference

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Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

30 September 2017

1 reference

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Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations

30 September 2017

1 reference

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Ral overactivation in malignant peripheral nerve sheath tumors

30 September 2017

1 reference

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(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

30 September 2017

1 reference

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Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow

30 September 2017

1 reference

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Somatic mutations affect key pathways in lung adenocarcinoma

30 September 2017

1 reference

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How does the Schwann cell lineage form tumors in NF1?

30 September 2017

1 reference

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Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors

30 September 2017

1 reference

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Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors

30 September 2017

1 reference

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The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells

30 September 2017

1 reference

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Induction of abnormal proliferation by nonmyelinating schwann cells triggers neurofibroma formation

30 September 2017

1 reference

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Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells

30 September 2017

1 reference

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The selectivity of protein kinase inhibitors: a further update

30 September 2017

1 reference

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Tumor microenvironment and neurofibromatosis type I: connecting the GAPs

30 September 2017

1 reference

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Pathophysiology of neurofibromatosis type 1.

30 September 2017

1 reference

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Mechanisms of drug inhibition of signalling molecules

30 September 2017

1 reference

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Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues

30 September 2017

1 reference

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BRAF mutation predicts sensitivity to MEK inhibition

30 September 2017

1 reference

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The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines

30 September 2017

1 reference

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Malignant peripheral nerve sheath tumors with high and low Ras-GTP are permissive for oncolytic herpes simplex virus mutants

30 September 2017

1 reference

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The NF1 tumor suppressor critically regulates TSC2 and mTOR.

30 September 2017

1 reference

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Targeting the mitogen-activated protein kinase cascade to treat cancer

30 September 2017

1 reference

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Targeting RAS signalling pathways in cancer therapy

30 September 2017

1 reference

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Nf1 has an essential role in endothelial cells

30 September 2017

1 reference

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Malignant peripheral nerve sheath tumours in neurofibromatosis 1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533264

Neurofibromas in NF1: Schwann cell origin and role of tumor environment

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533264

Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533264

Hyperactive Ras as a therapeutic target in neurofibromatosis type 1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533264

30 September 2017

Ras signaling and NF1.

1 reference

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Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533264

Further evidence of the increased risk for malignant peripheral nerve sheath tumour from a Scottish cohort of patients with neurofibromatosis type 1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533264

Tumour biology: senescence in premalignant tumours

28 June 2018

1 reference

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Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533264

Back to the future: proceedings from the 2010 NF Conference.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533264

Phase I pharmacokinetic and pharmacodynamic study of the oral MAPK/ERK kinase inhibitor PD-0325901 in patients with advanced cancers

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533264

NF1 plexiform neurofibroma growth rate by volumetric MRI: relationship to age and body weight.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533264

A negative feedback signaling network underlies oncogene-induced senescence

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533264

Somatic loss of wild type NF1 allele in neurofibromas: Comparison of NF1 microdeletion and non-microdeletion patients.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533264

An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533264

Automated detection and volume measurement of plexiform neurofibromas in neurofibromatosis 1 using magnetic resonance imaging

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533264

21 September 2018

Senescence comes of age

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533264

Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration

4 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23221341

12 December 2020

inferred from PubMed ID database lookup

Pediatric Malignant Peripheral Nerve Sheath Tumor: The Italian and German Soft Tissue Sarcoma Cooperative Group

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23221341

12 December 2020

inferred from PubMed ID database lookup

Malignant peripheral nerve sheath tumors (MPNST) in NF1-affected children

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23221341

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1172/JCI60578

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23221341%20AND%20SRC:MED&resulttype=core&format=json