(Q36497201)

14 August 2017

Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. (English)

1 reference

14 August 2017

Tiffany Chang

1

1 reference

14 August 2017

Kimberly Krisman

2

1 reference

14 August 2017

Emily Harding Theobald

3

1 reference

14 August 2017

Jin Xu

4

1 reference

14 August 2017

Jon Akutagawa

5

1 reference

14 August 2017

Jennifer O Lauchle

6

1 reference

14 August 2017

Scott Kogan

7

1 reference

14 August 2017

Benjamin S Braun

8

1 reference

14 August 2017

Kevin Shannon

9

1 reference

14 August 2017

language of work or name

English

0 references

publication date

10 December 2012

1 reference

Journal of Clinical Investigation

14 August 2017

1 reference

14 August 2017

123

1 reference

14 August 2017

1

1 reference

14 August 2017

335-339

1 reference

Targeting oncogenic Ras signaling in hematologic malignancies

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

MEK1 mutations confer resistance to MEK and B-RAF inhibition

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

Germline KRAS mutations cause Noonan syndrome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

Focus on myeloproliferative diseases and myelodysplastic syndromes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

NF1 tumor suppressor gene function: narrowing the GAP

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533281

Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23221337

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI63193

1 reference

14 August 2017

1 reference

14 August 2017

1 reference