(Q36503230)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232398%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements (English)

1 reference

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20 February 2020

4

1 reference

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20 February 2020

Esperanza Perucha

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232398%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Graham M Lord

7

1 reference

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20 February 2020

Richard G. Jenner

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232398%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

author name string

Aditi Kanhere

1

1 reference

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20 February 2020

Arnulf Hertweck

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232398%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Urvashi Bhatia

3

1 reference

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20 February 2020

Ian Jackson

6

1 reference

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20 February 2020

language of work or name

English

0 references

publication date

1 January 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232398%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

published in

Nature Communications

1 reference

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20 February 2020

volume

3

1 reference

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20 February 2020

page(s)

1268

1 reference

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Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

20 February 2020

copyright license

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types

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Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3

30 September 2017

1 reference

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Differentiation of effector CD4 T cell populations (*)

30 September 2017

1 reference

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Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells

30 September 2017

1 reference

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Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

30 September 2017

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Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection

30 September 2017

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CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus

30 September 2017

1 reference

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The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

30 September 2017

1 reference

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Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus

30 September 2017

1 reference

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Epigenetic control of T-helper-cell differentiation

30 September 2017

1 reference

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Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation

30 September 2017

1 reference

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Model-based analysis of ChIP-Seq (MACS)

30 September 2017

1 reference

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Long-range regulation of cytokine gene expression.

30 September 2017

1 reference

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TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma

30 September 2017

1 reference

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High-resolution profiling of histone methylations in the human genome

30 September 2017

1 reference

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GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

A critical control element for interleukin-4 memory expression in T helper lymphocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis

30 September 2017

1 reference

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Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling.

30 September 2017

1 reference

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Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes

30 September 2017

1 reference

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Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

A novel transcription factor, T-bet, directs Th1 lineage commitment

30 September 2017

1 reference

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Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3.

30 September 2017

1 reference

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Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene

30 September 2017

1 reference

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Multiple defects of immune cell function in mice with disrupted interferon-gamma genes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

Positive-feedback loops as a flexible biological module

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

28 June 2018

1 reference

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Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.

28 June 2018

1 reference

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Integration of distinct intracellular signaling pathways at distal regulatory elements directs T-bet expression in human CD4+ T cells

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

A distal conserved sequence element controls Ifng gene expression by T cells and NK cells.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

T-bet is required for protection against vaccinia virus infection

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell Differentiation

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535338

Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

21 September 2018

1 reference

12 December 2020

Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level

1 reference

12 December 2020

The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3

1 reference

12 December 2020

Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet

1 reference

12 December 2020

Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus

1 reference

12 December 2020

A Distal Enhancer in the Interferon-γ (IFN-γ) Locus Revealed by Genome Sequence Comparison

1 reference

12 December 2020

Long-range intrachromosomal interactions in the T helper type 2 cytokine locus

1 reference

12 December 2020

Deletion of a conserved Il4 silencer impairs T helper type 1–mediated immunity

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS2260

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232398%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232398%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PubMed publication ID

23232398

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232398%20AND%20SRC:MED&resulttype=core&format=json