(Q36520549)

English

Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification

scientific article published on 3 December 2015

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scholarly article

1 reference

Europe PubMed Central

14 August 2017

Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification (English)

1 reference

Europe PubMed Central

14 August 2017

SRY-box transcription factor 9

1 reference

GOA release 2020-03-11

transforming growth factor beta 1

1 reference

GOA release 2020-03-11

Transforming growth factor, beta 1

1 reference

GOA release 2020-03-11

author name string

Danielle J Huk

1

1 reference

Europe PubMed Central

14 August 2017

Blair F Austin

2

1 reference

Europe PubMed Central

14 August 2017

Tori E Horne

3

1 reference

Europe PubMed Central

14 August 2017

Robert B Hinton

4

1 reference

Europe PubMed Central

14 August 2017

William C Ray

5

1 reference

Europe PubMed Central

14 August 2017

Donald D Heistad

6

1 reference

Europe PubMed Central

14 August 2017

Joy Lincoln

7

1 reference

Europe PubMed Central

14 August 2017

language of work or name

0 references

publication date

3 December 2015

1 reference

Europe PubMed Central

14 August 2017

Arteriosclerosis, Thrombosis, and Vascular Biology

1 reference

Europe PubMed Central

14 August 2017

36

1 reference

Europe PubMed Central

14 August 2017

328-338

1 reference

Europe PubMed Central

14 August 2017

2

1 reference

Europe PubMed Central

14 August 2017

Cadherin-11 coordinates cellular migration and extracellular matrix remodeling during aortic valve maturation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Loss of β-catenin promotes chondrogenic differentiation of aortic valve interstitial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

TGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

The living aortic valve: From molecules to function.

1 reference

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30 September 2017

Etiology of valvular heart disease-genetic and developmental origins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

The role of valvular endothelial cell paracrine signaling and matrix elasticity on valvular interstitial cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Potential drug targets for calcific aortic valve disease.

1 reference

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30 September 2017

Heart disease and stroke statistics--2014 update: a report from the American Heart Association

1 reference

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30 September 2017

Tgfβ-Smad and MAPK signaling mediate scleraxis and proteoglycan expression in heart valves

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Oxidative stress and nitric oxide pathway in adult patients who are candidates for cardiac surgery: patterns and differences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

TGF-β signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Aortic valve: mechanical environment and mechanobiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Side-specific endothelial-dependent regulation of aortic valve calcification: interplay of hemodynamics and nitric oxide signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Inhibitory role of Notch1 in calcific aortic valve disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Isolation and culture of pulmonary endothelial cells from neonatal mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Role of the Rho pathway in regulating valvular interstitial cell phenotype and nodule formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Insights into the use of biomarkers in calcific aortic valve disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

SOX9 determines RUNX2 transactivity by directing intracellular degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Reduced sox9 function promotes heart valve calcification phenotypes in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Rho kinase-dependent activation of SOX9 in chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Overexpression of transforming growth factor-beta 1 in the valvular fibrosis of chronic rheumatic heart disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Cofilin is a marker of myofibroblast differentiation in cells from porcine aortic cardiac valves

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Dominance of SOX9 function over RUNX2 during skeletogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Mutations in NOTCH1 cause aortic valve disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

SOX9-dependent and -independent transcriptional regulation of human cartilage link protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Sox9 is required for cartilage formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

SOX9 directly regulates the type-II collagen gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Hemodynamics and atherosclerosis. Insights and perspectives gained from studies of human arteries.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

30 September 2017

Isolation of valvular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

28 June 2018

TGF-beta1-Induced MAPK activation promotes collagen synthesis, nodule formation, redox stress and cellular senescence in porcine aortic valve interstitial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

21 September 2018

A novel mouse model of aortic valve stenosis induced by direct wire injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

21 September 2018

Lowering plasma cholesterol levels halts progression of aortic valve disease in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

21 September 2018

Transforming growth factor-beta1 mechanisms in aortic valve calcification: increased alkaline phosphatase and related events.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

21 September 2018

Role of human valve interstitial cells in valve calcification and their response to atorvastatin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

21 September 2018

BMP and FGF regulatory pathways control cell lineage diversification of heart valve precursor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

21 September 2018

Valvular endothelial cells regulate the phenotype of interstitial cells in co-culture: effects of steady shear stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

21 September 2018

Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

21 September 2018

Expression patterns of Tgfbeta1-3 associate with myocardialisation of the outflow tract and the development of the epicardium and the fibrous heart skeleton.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

21 September 2018

Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4732913

21 September 2018

Metallothionein-dependent up-regulation of TGF-β2 participates in the remodelling of the myxomatous mitral valve

1 reference

https://pubmed.ncbi.nlm.nih.gov/26634652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcific aortic valve stenosis in old hypercholesterolemic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/26634652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular Matrix Remodeling and Organization in Developing and Diseased Aortic Valves

1 reference

https://pubmed.ncbi.nlm.nih.gov/26634652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1161/ATVBAHA.115.306091

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

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