(Q36522556)

English

Targeted inhibition of phosphoinositide 3-kinase activity as a novel strategy to normalize beta-adrenergic receptor function in heart failure

scientific article published on 27 June 2006

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

1 reference

Europe PubMed Central

Targeted inhibition of phosphoinositide 3-kinase activity as a novel strategy to normalize beta-adrenergic receptor function in heart failure (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

object named as

Cinzia Perrino

1

0 references

author name string

Howard A Rockman

2

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

Massimo Chiariello

3

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

publication date

27 June 2006

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

Vascular Pharmacology

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Europe PubMed Central

PubMed publication ID

14 August 2017

45

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

77-85

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy

1 reference

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Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility

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Myocardial-directed overexpression of the human beta(1)-adrenergic receptor in transgenic mice

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Why does the myocardium fail? Insights from basic science

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Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

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Reduced beta 1 receptor messenger RNA abundance in the failing human heart

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Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

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beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

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PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

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Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.

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Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.

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Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits

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Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding

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Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure

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Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

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Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

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Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade

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Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression

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Regulation of Ca2+ signaling in transgenic mouse cardiac myocytes overexpressing calsequestrin

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Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

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The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification

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The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits

1 reference

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beta-arrestins: traffic cops of cell signaling

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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

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Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy

1 reference

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Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy

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Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration

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Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex

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Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis

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Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure

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Regulation of cardiac contractility by Rab4-modulated beta2-adrenergic receptor recycling

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PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

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Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex

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Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression

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Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction

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Arresting developments in heptahelical receptor signaling and regulation

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The β-adrenergic receptor kinase in heart failure

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New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

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Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart

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Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy.

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Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy

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Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

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Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

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Noradrenaline is essential for mouse fetal development

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Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

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Synthesis and function of 3-phosphorylated inositol lipids

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Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction

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10.1016/J.VPH.2006.01.018

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

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