(Q36545029)

14 August 2017

1 reference

title

Active transport across the human placenta: impact on drug efficacy and toxicity (English)

1 reference

14 August 2017

1

Denis Evseenko

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14 August 2017

3

Jeffrey A Keelan

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14 August 2017

James W Paxton

2

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14 August 2017

language of work or name

English

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publication date

1 February 2006

1 reference

Expert Opinion on Drug Metabolism & Toxicology

14 August 2017

published in

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14 August 2017

volume

2

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14 August 2017

issue

1

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14 August 2017

page(s)

51-69

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National Institute on Drug Abuse Conference report on placental proteins, drug transport, and fetal development

14 August 2017

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21 January 2018

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21 January 2018

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Pharmacology of drug transfer across the placenta

21 January 2018

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Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption

21 January 2018

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UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term

21 January 2018

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Efflux transporters of the human placenta

21 January 2018

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P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages

21 January 2018

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21 January 2018

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Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport

21 January 2018

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Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells

21 January 2018

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From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance.

21 January 2018

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Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2.1.51

The role of multidrug transporters in drug availability, metabolism and toxicity

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Human placental transport of vinblastine, vincristine, digoxin and progesterone: contribution of P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Stage-specific distribution of P-glycoprotein in first-trimester and full-term human placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Kinetic analysis of P-glycoprotein-mediated transport by using normal human placental brush-border membrane vesicles.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Basal Membrane Localization of MRP1 in Human Placental Trophoblast

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2.1.51

MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2.1.51

ABC transporters in lipid transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Semi quantitative expression analysis of MDR3, FIC1, BSEP, OATP-A, OATP-C,OATP-D, OATP-E and NTCP gene transcripts in 1st and 3rd trimester human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Mechanisms for the transport of unconjugated bilirubin in human trophoblastic BeWo cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Effects of maturation on RNA transcription and protein expression of four MRP genes in human placenta and in BeWo cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Structural, mechanistic and clinical aspects of MRP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Mrp4 confers resistance to topotecan and protects the brain from chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Real-time reverse transcription-PCR expression profiling of the complete human ATP-binding cassette transporter superfamily in various tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

ABCG2 -- a transporter for all seasons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Cyclosporin A is a broad-spectrum multidrug resistance modulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Organic anion transporter (Slc22a) family members as mediators of toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

The multispecific organic anion transporter family: properties and pharmacological significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Characterization and identification of steroid sulfate transporters of human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

The organic anion transporter (OATP) family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Conditionally immortalized syncytiotrophoblast cell lines as new tools for study of the blood-placenta barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Expression, localization, and function of the carnitine transporter octn2 (slc22a5) in human placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Cocaine up-regulates norepinephrine transporter binding in the rat placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Immunolocalisation of nucleoside transporters in human placental trophoblast and endothelial cells: evidence for multiple transporter isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Polarized lactate transporter activity and expression in the syncytiotrophoblast of the term human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Children exposed to chemotherapy in utero

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Obstetrical deliveries associated with maternal malignancy in California, 1992 through 1997.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Cancer in pregnancy: a review of the literature. Part I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Review of the potential effects of three commonly used antineoplastic and immunosuppressive drugs (cyclophosphamide, azathioprine, doxorubicin on the embryo and placenta).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Hematological malignancies and pregnancy: a final report of 84 children who received chemotherapy in utero

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Pregnancy and the cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Pregnancy in patients with heart disease: experience with 1,000 cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Rifampicin reduces plasma concentrations of celiprolol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Hypertension therapy during pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

MDR1-mediated interaction of digoxin with antiarrhythmic or antianginal drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Human placental perfusion method in the assessment of transplacental passage of antiepileptic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Valproic acid uptake by bovine brain microvessel endothelial cells: role of active efflux transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Antidepressant drug use in pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

The safety of newer antidepressants in pregnancy and breastfeeding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Follow-up of children of depressed mothers exposed or not exposed to antidepressant drugs during pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Transplacental transfer of amitriptyline and nortriptyline in isolated perfused human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-Glycoprotein gene disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Transplacental transfer of citalopram, fluoxetine and their primary demethylated metabolites in isolated perfused human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Citalopram in pregnancy and lactation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Placental passage of antidepressant medications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Maternal fluoxetine infusion does not alter fetal endocrine and biophysical circadian rhythms in pregnant sheep

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Prevention of mother-to-child transmission of HIV at Maiduguri, Nigeria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Transplacental genotoxicity of combined antiretroviral nucleoside analogue therapy in Erythrocebus patas monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Human placental glucuronidation and transport of 3'azido-3'-deoxythymidine and uridine diphosphate glucuronic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

3'-azido-3'-deoxythymidine (AZT) induces apoptosis and alters metabolic enzyme activity in human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Transfer of antivirals across the human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Transplacental passage of protease inhibitors at delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Functional role of P-glycoprotein in the human blood-placental barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Clinical aspects of the MDR1 (ABCB1) gene polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Importance of P-glycoprotein at blood-tissue barriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Pharmacogenetics of drug transporters and its impact on the pharmacotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Variable expression of MRP2 (ABCC2) in human placenta: influence of gestational age and cellular differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

Drugs and the Placenta—A Workshop Report

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.1.51

21 January 2018

Identifiers

DOI

10.1517/17425255.2.1.51

1 reference

14 August 2017

1 reference