(Q36568542)

English

"Click peptides"--chemical biology-oriented synthesis of Alzheimer's disease-related amyloid beta peptide (abeta) analogues based on the "O-acyl isopeptide method".

scientific article published on October 2006

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scholarly article

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Europe PubMed Central

PubMed publication ID

15 August 2017

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Europe PubMed Central

"Click peptides"--chemical biology-oriented synthesis of Alzheimer's disease-related amyloid beta peptide (abeta) analogues based on the "O-acyl isopeptide method". (English)

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

Alzheimer's disease

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author name string

Youhei Sohma

1

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

Yoshiaki Kiso

2

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

publication date

1 October 2006

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Europe PubMed Central

PubMed publication ID

15 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

7

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Europe PubMed Central

PubMed publication ID

15 August 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

1549-1557

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

1 reference

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21 January 2018

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

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21 January 2018

1 reference

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21 January 2018

A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization

1 reference

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21 January 2018

Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation

1 reference

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21 January 2018

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

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21 January 2018

Rational design and synthesis of a novel class of active site-targeted HIV protease inhibitors containing a hydroxymethylcarbonyl isostere. Use of phenylnorstatine or allophenylnorstatine as a transition-state mimic

1 reference

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21 January 2018

Kynostatin (KNI)-227 and -272, highly potent anti-HIV agents: conformationally constrained tripeptide inhibitors of HIV protease containing allophenylnorstatine

1 reference

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21 January 2018

Design and synthesis of substrate-based peptidomimetic human immunodeficiency virus protease inhibitors containing the hydroxymethylcarbonyl isostere

1 reference

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21 January 2018

Identification and characterization of allophenylnorstatine-based inhibitors of plasmepsin II, an antimalarial target.

1 reference

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21 January 2018

Search for substrate-based inhibitors fitting the S2' space of malarial aspartic protease plasmepsin II.

1 reference

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21 January 2018

KMI-008, a novel beta-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic: design and synthesis of substrate-based octapeptides

1 reference

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KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine

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Design and synthesis of highly active Alzheimer's beta-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability

1 reference

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21 January 2018

The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice

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21 January 2018

Design and synthesis of potent beta-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres

1 reference

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21 January 2018

The 'O-acyl isopeptide method' for the synthesis of difficult sequence-containing peptides: application to the synthesis of Alzheimer's disease-related amyloid beta peptide (Abeta) 1-42.

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600112

21 January 2018

"Click peptide" based on the "o-acyl isopeptide method": control of A beta1-42 production from a photo-triggered A beta1-42 analogue

1 reference

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21 January 2018

The fluorenylmethoxycarbonyl group in solid phase synthesis

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600112

21 January 2018

Chemical synthesis of peptides and proteins

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600112

21 January 2018

Synthesis of potent beta-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies

1 reference

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21 January 2018

New water-soluble prodrugs of HIV protease inhibitors based on O-->N intramolecular acyl migration

1 reference

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21 January 2018

O-N intramolecular acyl migration strategy in water-soluble prodrugs of taxoids

1 reference

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21 January 2018

No auxiliary, no byproduct strategy for water-soluble prodrugs of taxoids: scope and limitation of O-N intramolecular acyl and acyloxy migration reactions

1 reference

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21 January 2018

O-N intramolecular alkoxycarbonyl migration of typical protective groups in hydroxyamino acids

1 reference

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21 January 2018

CXIX.—The formation and stability of spiro-compounds. Part I. spiro-Compounds from cyclohexane

1 reference

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21 January 2018

Switch peptides in statu nascendi: induction of conformational transitions relevant to degenerative diseases.

1 reference

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21 January 2018

Switch-peptides: controlling self-assembly of amyloid beta-derived peptides in vitro by consecutive triggering of acyl migrations.

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600112

21 January 2018

Fibrillogenesis of synthetic amyloid-beta peptides is dependent on their initial secondary structure

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600112

21 January 2018

Alzheimer beta-amyloid peptides: structures of amyloid fibrils and alternate aggregation products

1 reference

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Solvent effects on self-assembly of beta-amyloid peptide

1 reference

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21 January 2018

In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

1 reference

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21 January 2018

Improved preparation of amyloid-beta peptides using DBU as Nalpha-Fmoc deprotection reagent.

1 reference

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21 January 2018

Amyloid-beta as a "difficult sequence" in solid phase peptide synthesis

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600112

21 January 2018

Biological tuning of synthetic tactics in solid-phase synthesis: application to A beta(1-42).

1 reference

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21 January 2018

Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease.

1 reference

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21 January 2018

ChemMatrix, a poly(ethylene glycol)-based support for the solid-phase synthesis of complex peptides

1 reference

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Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

1 reference

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The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

1 reference

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21 January 2018

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type

1 reference

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Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy

1 reference

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Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600112

21 January 2018

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

1 reference

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21 January 2018

Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation

1 reference

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Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease

1 reference

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Environment- and mutation-dependent aggregation behavior of Alzheimer amyloid beta-protein

1 reference

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21 January 2018

Assembly of hereditary amyloid beta-protein variants in the presence of favorable gangliosides.

1 reference

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21 January 2018

Solvent and mutation effects on the nucleation of amyloid beta-protein folding

1 reference

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21 January 2018

Folding character of cytochrome c studied by o-nitrobenzyl modification of methionine 65 and subsequent ultraviolet light irradiation.

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A sea urchin egg jelly peptide induces a cGMP-mediated decrease in sperm intracellular Ca(2+) before its increase.

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A genetically encoded photocaged amino acid

1 reference

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Photocontrol of Smad2, a multiphosphorylated cell-signaling protein, through caging of activating phosphoserines

1 reference

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In situ photoactivation of a caged phosphotyrosine peptide derived from focal adhesion kinase temporarily halts lamellar extension of single migrating tumor cells.

1 reference

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A ligation and photorelease strategy for the temporal and spatial control of protein function in living cells.

1 reference

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21 January 2018

Oxygen binding to tyrosinase from streptomyces antibioticus studied by laser flash photolysis

1 reference

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21 January 2018

Synthesis and photoreactivity of caged blockers for glutamate transporters.

1 reference

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21 January 2018

A protecting group for carboxylic acids that can be photolyzed by visible light

1 reference

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21 January 2018

Photolytic control of peptide self-assembly

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600112

21 January 2018

Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid

1 reference

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Getting out of shape

1 reference

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Critical balance of electrostatic and hydrophobic interactions is required for beta 2-microglobulin amyloid fibril growth and stability

1 reference

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The pathway by which the tetrameric protein transthyretin dissociates.

1 reference

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Parallel beta-sheets and polar zippers in amyloid fibrils formed by residues 10-39 of the yeast prion protein Ure2p

1 reference

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Influence of the N-terminal domain on the aggregation properties of the prion protein

1 reference

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Probing PrPSc structure using chemical cross-linking and mass spectrometry: evidence of the proximity of Gly90 amino termini in the PrP 27-30 aggregate

1 reference

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Lipid membranes modulate the structure of islet amyloid polypeptide.

1 reference

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Characterization of oligomers during alpha-synuclein aggregation using intrinsic tryptophan fluorescence

1 reference

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Coupling Difficulty Associated with Interchain Clustering and Phase Transition in Solid Phase Peptide Synthesis

1 reference

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O–N-Acyl migration in N-terminal serine-containing peptides: mass spectrometric elucidation and subsequent development of site-directed acylation protocols

1 reference

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21 January 2018

Identifiers

10.1002/CBIC.200600112

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

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