(Q36572571)

15 August 2017

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title

Metabolism of ATP-binding cassette drug transporter inhibitors: complicating factor for multidrug resistance (English)

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15 August 2017

main subject

multiple drug resistance

1 reference

Nicole H P Cnubben

1

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15 August 2017

Heleen M Wortelboer

2

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15 August 2017

Jelmer J van Zanden

3

1 reference

15 August 2017

Ivonne M C M Rietjens

4

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15 August 2017

Peter J van Bladeren

5

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15 August 2017

language of work or name

English

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publication date

1 August 2005

1 reference

Expert Opinion on Drug Metabolism & Toxicology

15 August 2017

published in

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15 August 2017

volume

1

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15 August 2017

issue

2

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15 August 2017

page(s)

219-232

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Mechanisms of cancer drug resistance

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

A family of drug transporters: the multidrug resistance-associated proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Mammalian ABC transporters in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Considerations in the design and development of transport inhibitors as adjuncts to drug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Structure and function of efflux pumps that confer resistance to drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Multidrug transport by ATP binding cassette transporters: a proposed two-cylinder engine mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments]

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Adenosine triphosphate-dependent transport of estradiol-17beta(beta-D-glucuronide) in membrane vesicles by MDR1 expressed in insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Function of prokaryotic and eukaryotic ABC proteins in lipid transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

ABC transporters in lipid transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

The (patho)physiological functions of the MRP family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

The interplay of glutathione-related processes in antioxidant defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Mechanism of GST A1-1- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

The medicinal chemistry of multidrug resistance (MDR) reversing drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

A review of selected anti-tumour therapeutic agents and reasons for multidrug resistance occurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

MDR1 inhibition: less resistance or less relevance?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

ATP binding cassette transporters and drug resistance in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Glutathione and related enzymes in multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

ABCG2 -- a transporter for all seasons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

The MRP family of drug efflux pumps

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Enhancement of glucuronosyl etoposide transport by glutathione in multidrug resistance-associated protein-overexpressing cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

A multidrug resistance transporter from human MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Breast cancer resistance protein exports sulfated estrogens but not free estrogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Interaction of the breast cancer resistance protein with plant polyphenols

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Evidence for carrier-mediated transport of unconjugated bilirubin across plasma membrane vesicles from human placental trophoblast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

The ABC transporters MDR1 and MRP2: multiple functions in disposition of xenobiotics and drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

New directions in cancer research 2003: technological advances in biology, drug resistance, and molecular pharmacology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

The Role of ABC Transporters in Clinical Practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Improvement of oral drug treatment by temporary inhibition of drug transporters and/or cytochrome P450 in the gastrointestinal tract and liver: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Signal transduction pathways and transcriptional mechanisms as targets for prevention of emergence of multidrug resistance in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

MRP1 gene expression level regulates the death and differentiation response of neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Reduction of expression of the multidrug resistance protein (MRP) in human tumor cells by antisense phosphorothioate oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Does P-glycoprotein play a role in anticancer drug pharmacokinetics?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Structure-activity relationship of indomethacin analogues for MRP-1, COX-1 and COX-2 inhibition. identification of novel chemotherapeutic drug resistance modulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Differential multidrug resistance-associated protein 1 through 6 isoform expression and function in human intestinal epithelial Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Structure-activity studies of verapamil analogs that modulate transport of leukotriene C(4) and reduced glutathione by multidrug resistance protein MRP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Double-edged sword of chemosensitizer: increase of multidrug resistance protein (MRP) in leukemic cells by an MRP inhibitor probenecid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Indomethacin-mediated reversal of multidrug resistance and drug efflux in human and murine cell lines overexpressing MRP, but not P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Reversing effect of agosterol A, a spongean sterol acetate, on multidrug resistance in human carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Potent interaction of flavopiridol with MRP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Acceleration of MRP-associated efflux of rhodamine 123 by genistein and related compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Effect of flavonoids on MRP1-mediated transport in Panc-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

The sulphonylurea glibenclamide inhibits multidrug resistance protein (MRP1) activity in human lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Inhibition of the multidrug resistance protein 1 (MRP1) by peptidomimetic glutathione-conjugate analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Photolabeling of human and murine multidrug resistance protein 1 with the high affinity inhibitor [125I]LY475776 and azidophenacyl-[35S]glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Human breast cancer resistance protein: interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Novel bicistronic retroviral vector expressing gamma-glutamylcysteine synthetase and the multidrug resistance protein 1 (MRP1) protects cells from MRP1-effluxed drugs and alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

The role of glutathione-S-transferase in anti-cancer drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

The inhibition of glutathione S-transferases: Mechanisms, toxic consequences and therapeutic benefits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Sensitization to the cytotoxicity of melphalan by ethacrynic acid and hyperthermia in drug-sensitive and multidrug-resistant Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Identification of 14 quercetin phase II mono- and mixed conjugates and their formation by rat and human phase II in vitro model systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of alpha,beta-unsaturated carbonyl compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Inhibitory effects of plant polyphenols on rat liver glutathione S-transferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Inhibition of human glutathione S-transferase P1-1 by the flavonoid quercetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

The effect of the flavonoids, quercetin, myricetin and epicatechin on the growth and enzyme activities of MCF7 human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Influences of glutathione on anionic substrate efflux in tumour cells expressing the multidrug resistance-associated protein, MRP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

Multiple flavonoid-binding sites within multidrug resistance protein MRP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.2.219

21 January 2018

Identifiers

DOI

10.1517/17425255.1.2.219

1 reference

15 August 2017

1 reference