(Q36575932)

15 August 2017

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title

The challenge of predicting drug toxicity in silico (English)

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15 August 2017

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Angelo Vedani

1

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15 August 2017

Max Dobler

series ordinal

2

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15 August 2017

Markus A Lill

series ordinal

3

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15 August 2017

publication date

1 September 2006

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Basic and Clinical Pharmacology and Toxicology

15 August 2017

published in

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15 August 2017

volume

99

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15 August 2017

issue

3

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15 August 2017

page(s)

195-208

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Toxicokinetic modeling and its applications in chemical risk assessment

15 August 2017

cites work

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AM1-SM2 and PM3-SM3 parameterized SCF solvation models for free energies in aqueous solution

21 January 2018

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Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins

21 January 2018

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Substituted polychlorinated dibenzofuran receptor binding affinities and aryl hydrocarbon hydroxylase induction potencies--a QSAR analysis.

21 January 2018

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Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel

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Receptor-mediated effects of chlorinated hydrocarbons

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A MATHEMATICAL CONTRIBUTION TO STRUCTURE-ACTIVITY STUDIES.

21 January 2018

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Comparative QSAR analysis of estrogen receptor ligands

21 January 2018

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Receptor-mediated toxicity

21 January 2018

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Lipophilic Character and Biological Activity of Drugs II: The Parabolic Case

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In silico tools to aid risk assessment of endocrine disrupting chemicals

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Estrogen receptor stereochemistry: receptor binding and hormonal responses.

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The Ah receptor and the mechanism of dioxin toxicity

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Thyroid hormone receptors: multiple forms, multiple possibilities

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Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals

21 January 2018

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Tuning neural and fuzzy-neural networks for toxicity modeling

21 January 2018

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Modeling toxicity by using supervised kohonen neural networks

21 January 2018

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The Ah receptor: mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds

21 January 2018

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Receptor-mediated hepatocarcinogenesis: role of hepatocyte proliferation and apoptosis

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Quantitative structure-activity relationship methods: perspectives on drug discovery and toxicology

21 January 2018

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Estimating relative potency for receptor-mediated toxicity: reevaluating the toxicity equivalence factor (TEF) model

21 January 2018

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Ah receptor-based chemical screening bioassays: application and limitations for the detection of Ah receptor agonists

21 January 2018

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QSAR models using a large diverse set of estrogens

21 January 2018

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The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

21 January 2018

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Clinically important pharmacokinetic drug-drug interactions: role of cytochrome P450 enzymes

21 January 2018

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Structure-activity relationship approaches and applications

21 January 2018

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On model building in structure-activity relationships. A reexamination of adrenergic blocking activity of beta-halo-beta-arylalkylamines.

21 January 2018

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In silico prediction of harmful effects triggered by drugs and chemicals

21 January 2018

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Combining protein modeling and 6D-QSAR. Simulating the binding of structurally diverse ligands to the estrogen receptor.

21 January 2018

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Novel ligands for the chemokine receptor-3 (CCR3): a receptor-modeling study based on 5D-QSAR.

21 January 2018

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5D-QSAR: the key for simulating induced fit?

21 January 2018

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Multiple-conformation and protonation-state representation in 4D-QSAR: the neurokinin-1 receptor system.

21 January 2018

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A comparative QSAR study using CoMFA, HQSAR, and FRED/SKEYS paradigms for estrogen receptor binding affinities of structurally diverse compounds

21 January 2018

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Mechanistic aspects of dioxin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2006.PTO_471.X

Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1

21 January 2018

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10.1111/J.1742-7843.2006.PTO_471.X

21 January 2018

Identifiers

DOI

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15 August 2017

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