(Q36577116)

15 August 2017

1 reference

title

Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases (English)

1 reference

15 August 2017

Vicente E Torres

1

1 reference

PubMed ID

16932388

15 August 2017

Peter C Harris

series ordinal

2

1 reference

15 August 2017

1 January 2006

1 reference

Nature Clinical Practice Nephrology

15 August 2017

1 reference

15 August 2017

2

1 reference

15 August 2017

40-55; quiz 55

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15 August 2017

1

1 reference

Autosomal dominant polycystic kidney disease

15 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Autosomal Recessive Polycystic Kidney Disease: The Clinical Experience in North America

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Polycystic kidney disease: The complete structure of the PKD1 gene and its protein

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Analysis of the genomic sequence for the autosomal dominant polycystic kidney disease (PKD1) gene predicts the presence of a leucine-rich repeat. The American PKD1 Consortium (APKD1 Consortium)

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Characterization of the exon structure of the polycystic kidney disease 2 gene (PKD2)

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

PKHD1 mutations in autosomal recessive polycystic kidney disease (ARPKD).

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

A complete mutation screen of the ADPKD genes by DHPLC

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Depletion of PKD1 by an antisense oligodeoxynucleotide induces premature G1/S-phase transition

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Apoptosis and loss of renal tissue in polycystic kidney diseases

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

A microdissection study of cystic disease of the kidneys in adults

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Hereditary polycystic kidney disease (adult form): a microdissection study of two cases at an early stage of the disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

A transcriptional network in polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Molecular pathogenesis of ADPKD: the polycystin complex gets complex

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Disruption of polycystin-1 function interferes with branching morphogenesis of the ureteric bud in developing mouse kidneys.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Mispolarization of desmosomal proteins and altered intercellular adhesion in autosomal dominant polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Beta4 integrin and laminin 5 are aberrantly expressed in polycystic kidney disease: role in increased cell adhesion and migration

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Human disease: calcium signaling in polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Genetics and pathogenesis of polycystic kidney disease.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Polycystin-2 is an intracellular calcium release channel

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Bending the MDCK cell primary cilium increases intracellular calcium

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Beta1-integrins in the primary cilium of MDCK cells potentiate fibronectin-induced Ca2+ signaling

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Polycystins and mechanosensation in renal and nodal cilia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Optimization of hypolipidemic and antiplatelet treatment in the diabetic patient with renal disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

The Wnt signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

cAMP stimulates protein kinase B in a Wortmannin-insensitive manner

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Evidence for involvement of Wnt signaling pathway in IB-MECA mediated suppression of melanoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta -catenin-regulated cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Drosophila Pkd2 is haploid-insufficient for mediating optimal smooth muscle contractility

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Expression of polycystin-1 C-terminal fragment enhances the ATP-induced Ca2+ release in human kidney cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

The isolated polycystin-1 cytoplasmic COOH terminus prolongs ATP-stimulated Cl- conductance through increased Ca2+ entry

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Expression of polycystin-1 enhances endoplasmic reticulum calcium uptake and decreases capacitative calcium entry in ATP-stimulated MDCK cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Mechanisms of regulating the Raf kinase family

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Calmodulin-mediated activation of Akt regulates survival of c-Myc-overexpressing mouse mammary carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Calcium regulates the PI3K-Akt pathway in stretched osteoblasts

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Renal accumulation and excretion of cyclic adenosine monophosphate in a murine model of slowly progressive polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Functional properties of Ca2+-inhibitable type 5 and type 6 adenylyl cyclases and role of Ca2+ increase in the inhibition of intracellular cAMP content

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Inhibition by calcium of mammalian adenylyl cyclases

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Capacitative Ca2+ entry exclusively inhibits cAMP synthesis in C6-2B glioma cells. Evidence that physiologically evoked Ca2+ entry regulates Ca(2+)-inhibitable adenylyl cyclase in non-excitable cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Cellular localization of type 5 and type 6 ACs in collecting duct and regulation of cAMP synthesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Identification, quantitation, and cellular localization of PDE1 calmodulin-stimulated cyclic nucleotide phosphodiesterases

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Reciprocal regulation of calcium dependent and calcium independent cyclic AMP hydrolysis by protein phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

[Ca2+]i reduction increases cellular proliferation and apoptosis in vascular smooth muscle cells: relevance to the ADPKD phenotype

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Expansion of extracellular volume in early polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Intranephron localization and regulation of the V1a vasopressin receptor during chronic metabolic acidosis and dehydration in rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Peritubular AVP regulates bicarbonate reabsorption in cortical distal tubule via V(1) and V(2) receptors

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Sustained activation of MAPK/ERKs signaling pathway in cystic kidneys from bcl-2 -/- mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Effectiveness of vasopressin V2 receptor antagonists OPC-31260 and OPC-41061 on polycystic kidney disease development in the PCK rat.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

In vivo effects of activated H-ras oncogene expressed in the liver and in urogenital tissues.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Molecular genetic analysis of von Hippel-Lindau disease.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Differential effects of cAMP in neurons and astrocytes. Role of B-raf

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Cell condition-dependent regulation of ERK5 by cAMP.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Polycystin-1 transforms the cAMP growth-responsive phenotype of M-1 cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Cyclic AMP differentially regulates cell proliferation of normal human keratinocytes through ERK activation depending on the expression pattern of B-Raf

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells. Checkpoint of modulation by cyclic AMP.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

AQP3, p-AQP2, and AQP2 expression is reduced in polyuric rats with hypercalcemia: prevention by cAMP-PDE inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Glycosylation Is Important for Cell Surface Expression of the Water Channel Aquaporin-2 but Is Not Essential for Tetramerization in the Endoplasmic Reticulum

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Alterations in renal cytosolic phospholipase A2 and cyclooxygenases in polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Dietary conjugated linoleic acid reduces PGE2 release and interstitial injury in rat polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Defective epidermal growth factor gene expression in mice with polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Epidermal growth factor (EGF) expression in the congenital polycystic mouse kidney.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Expression of differentiation antigens and growth-related genes in normal kidney, autosomal dominant polycystic kidney disease, and renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Expression of transforming growth factor alpha and epidermal growth factor receptor in adult polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Abnormal polarization of EGF receptors and autocrine stimulation of cyst epithelial growth in human ADPKD

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Epidermal growth factor receptor expression is abnormal in murine polycystic kidney

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Epidermal growth factor and endothelin in cyst fluid from autosomal dominant polycystic kidney disease cases: possible evidence of heterogeneity in cystogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Hereditary error in epidermal growth factor prohormone metabolism in a rat model of autosomal dominant polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

In vitro formation and expansion of cysts derived from human renal cortex epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Tyrosine kinase activity of the EGF receptor in murine metanephric organ culture

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

In vitro modulation of cyst formation by a novel tyrosine kinase inhibitor.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

EGF receptor tyrosine kinase inhibition attenuates the development of PKD in Han:SPRD rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Volumetric determination of progression in autosomal dominant polycystic kidney disease by computed tomography

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Relationship between renal volume growth and renal function in autosomal dominant polycystic kidney disease: a longitudinal study.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Safety and efficacy of long-acting somatostatin treatment in autosomal-dominant polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0070

7 January 2021

Identifiers

DOI

10.1038/NCPNEPH0070

1 reference

15 August 2017

1 reference

PubMed ID

16932388