(Q36579655)

15 August 2017

Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of Leishmania major (English)

1 reference

15 August 2017

0 references

0 references

1 reference

1

Roderick A M Williams

1 reference

15 August 2017

Jeremy C Mottram

2

0 references

author name string

Graham H Coombs

series ordinal

3

1 reference

PMC publication ID

3561585

15 August 2017

language of work or name

English

0 references

publication date

19 November 2012

1 reference

Journal of Biological Chemistry

15 August 2017

1 reference

15 August 2017

288

1 reference

15 August 2017

5

1 reference

15 August 2017

3678-3690

1 reference

ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major

15 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Mitochondria and autophagy: critical interplay between the two homeostats

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Autophagy in immunity and cell-autonomous defense against intracellular microbes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

9 September 2017

Mechanisms of mitophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Autophagic degradation of mitochondria in white adipose tissue differentiation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Regulation of autophagy by ROS: physiology and pathology

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Autophagosome formation and molecular mechanism of autophagy.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Autophagy is essential for mouse sense of balance

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Post-Golgi Sec proteins are required for autophagy in Saccharomyces cerevisiae

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Mitochondrial dysfunction in neurodegenerative diseases.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Atg8 controls phagophore expansion during autophagosome formation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

ROS, mitochondria and the regulation of autophagy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Selective degradation of mitochondria by mitophagy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Caloric restriction and autophagy in Caenorhabditis elegans

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

C. elegans feeding defective mutants have shorter body lengths and increased autophagy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Inhibition of macroautophagy triggers apoptosis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

LC3 conjugation system in mammalian autophagy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Formation process of autophagosome is traced with Apg8/Aut7p in yeast

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Immune responses associated with susceptibility of C57BL/10 mice to Leishmania amazonensis.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

JNK-dependent Atg4 upregulation mediates asperphenamate derivative BBP-induced autophagy in MCF-7 cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Endoplasmic reticulum stress-induced apoptosis in Leishmania through Ca2+-dependent and caspase-independent mechanism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Overexpression of mitochondrial Leishmania major ascorbate peroxidase enhances tolerance to oxidative stress-induced programmed cell death and protein damage.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Gene disruptions indicate an essential function for the LmmCRK1 cdc2-related kinase of Leishmania mexicana.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Autophagy: a broad role in unconventional protein secretion?

28 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415372

Histopathological and neurological features of Atg4b knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415372

Autophagy, proteases and the sense of balance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415372

Atg4D at the interface between autophagy and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415372

3-Mercaptopyruvate sulfurtransferase of Leishmania contains an unusual C-terminal extension and is involved in thioredoxin and antioxidant metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415372

Targeted integration into a rRNA locus results in uniform and high level expression of transgenes in Leishmania amastigotes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415372

Rapid isolation of DNA from trypanosomatid protozoa using a simple 'mini-prep' procedure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415372

Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415372

Oxidation as a post-translational modification that regulates autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415372

Methionine oxidation as a major cause of the functional impairment of oxidized actin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415372

Role of intracellular cAMP in differentiation-coupled induction of resistance against oxidative damage in Leishmania donovani.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415372

Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415372

Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415372

A role for mitochondria in autophagy regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415372

Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561585

Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3

20 September 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.415372

21 January 2018

Identifiers

DOI

10.1074/JBC.M112.415372

1 reference

15 August 2017

1 reference

PMC publication ID

3561585

15 August 2017

PubMed publication ID

23166325

1 reference

PMC publication ID

3561585