(Q36585123)

15 August 2017

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title

Current concepts in the molecular genetics of pediatric brain tumors: implications for emerging therapies (English)

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15 August 2017

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6

Paul Northcott

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15 August 2017

8

James T Rutka

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15 August 2017

Mandeep S Tamber

1

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15 August 2017

Krishan Bansal

2

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15 August 2017

Muh-Lii Liang

3

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15 August 2017

Todd G Mainprize

4

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15 August 2017

Bodour Salhia

5

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15 August 2017

Michael Taylor

7

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15 August 2017

2 September 2006

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15 August 2017

Child's Nervous System

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15 August 2017

22

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15 August 2017

11

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15 August 2017

1379-1394

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https://scigraph.springernature.com/pub.10.1007/s00381-006-0187-3

15 August 2017

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cites work

Recurrent gains of 1q, 8 and 12 in the Ewing family of tumours by comparative genomic hybridization

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

Molecular genetics of pediatric soft tissue tumors: clinical application

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

Association of EWS-FLI1 type 1 fusion with lower proliferative rate in Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

Chromosome 17p deletion in human medulloblastoma: a missing checkpoint in the Hedgehog pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

Genomic imbalances in pediatric intracranial ependymomas define clinically relevant groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

Molecular genetic analysis of ependymal tumors. NF2 mutations and chromosome 22q loss occur preferentially in intramedullary spinal ependymomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

Chromosomal abnormalities subdivide ependymal tumors into clinically relevant groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

APC mutations in sporadic medulloblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

Whole genome DNA copy number changes identified by high density oligonucleotide arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

p53 expression and its relationship to DNA alterations in bone and soft tissue sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

Epigenetic silencing of the HIC-1 gene in human medulloblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00381-006-0187-3

Nonrandom chromosomal gains in pilocytic astrocytomas of childhood.

21 January 2018

1 reference

12 December 2020

Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults.

1 reference

12 December 2020

Comparative genomic hybridization using oligonucleotide microarrays and total genomic DNA.

1 reference

12 December 2020

Microarray analysis of pediatric ependymoma identifies a cluster of 112 candidate genes including four transcripts at 22q12.1-q13.3

1 reference

12 December 2020

The Hedgehog and Wnt signalling pathways in cancer

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12 December 2020

Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas.

1 reference

12 December 2020

Clinical and molecular stratification of disease risk in medulloblastoma

1 reference

12 December 2020

From signatures to models: understanding cancer using microarrays

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12 December 2020

Transcriptional profiling of medulloblastoma in children.

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12 December 2020

EWS/Fli-1 chimeric protein is a transcriptional activator

1 reference

12 December 2020

Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

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12 December 2020

Molecular biology and neurosurgery in the third millennium

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12 December 2020

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

1 reference

12 December 2020

Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma

1 reference

12 December 2020

Genomics, gene expression and DNA arrays

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12 December 2020

A clinicobiological model predicting survival in medulloblastoma.

1 reference

12 December 2020

Isochromosome 12p-positive pineal germ cell tumor.

1 reference

12 December 2020

TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors

1 reference

12 December 2020

Absence of p53 gene mutations in a tumor panel representative of pilocytic astrocytoma diversity using a p53 functional assay.

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12 December 2020

Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood

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12 December 2020

Comparative genomic hybridization

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12 December 2020

Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations.

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12 December 2020

Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling

1 reference

12 December 2020

ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma.

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12 December 2020

Loss of caspase-8 mRNA expression is common in childhood primitive neuroectodermal brain tumour/medulloblastoma.

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12 December 2020

Mutational analysis of the tyrosine kinome in colorectal cancers

1 reference

12 December 2020

Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling

1 reference

12 December 2020

Gene expression profile of ewing sarcoma cell lines differing in their EWS-FLI1 fusion type.

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12 December 2020

High resolution microarray comparative genomic hybridisation analysis using spotted oligonucleotides

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12 December 2020

Pediatric supratentorial high-grade gliomas.

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12 December 2020

Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway

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12 December 2020

Array comparative genomic hybridization and its applications in cancer

1 reference

12 December 2020

An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays

1 reference

12 December 2020

Mutations of the BRAF gene in human cancer

1 reference

12 December 2020

Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays.

1 reference

12 December 2020

A haplotype map of the human genome

1 reference

12 December 2020

Fusion of an ETS-family gene, EIAF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy

1 reference

12 December 2020

Somatic mutations of the protein kinase gene family in human lung cancer

1 reference

12 December 2020

Gene expression profiling of human cancers.

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12 December 2020

Combining gene expression profiles and clinical parameters for risk stratification in medulloblastomas.

1 reference

12 December 2020

Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas

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12 December 2020

A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1

1 reference

12 December 2020

PTEN gene mutations are seen in high-grade but not in low-grade gliomas.

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12 December 2020

Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumors

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12 December 2020

Monosomy 22 in rhabdoid or atypical tumors of the brain.

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12 December 2020

The ErbB signaling network: receptor heterodimerization in development and cancer

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12 December 2020

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

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12 December 2020

The ETS-domain transcription factor family

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12 December 2020

Application of bacterial artificial chromosome array-based comparative genomic hybridization and spectral karyotyping to the analysis of glioblastoma multiforme

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12 December 2020

Ets transcription factors and human disease.

1 reference

12 December 2020

Array CGH analysis of pediatric medulloblastomas.

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12 December 2020

Infrequency of p53 gene mutations in ependymomas

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12 December 2020

Genetic imbalances revealed by comparative genomic hybridization in Ewing tumors

1 reference

12 December 2020

Whole-genome patterns of common DNA variation in three human populations

1 reference

12 December 2020

Immature teratoma of the pineal gland with isochromosome 12p.

1 reference

12 December 2020

Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients

1 reference

12 December 2020

Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis

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12 December 2020

Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm.

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12 December 2020

Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study

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12 December 2020

Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors.

1 reference

12 December 2020

Intracranial germ cell tumour (embryonal carcinoma with teratoma) with complex karyotype including isochromosome 12p.

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12 December 2020

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

1 reference

12 December 2020

Comparative genomic hybridization (CGH)-arrays pave the way for identification of novel cancer-related genes

1 reference

12 December 2020

Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution

1 reference

12 December 2020

Molecular genetics of pediatric brain stem gliomas. Application of PCR techniques to small and archival brain tumor specimens

1 reference

12 December 2020

Molecular genetics of pineal region neoplasms

1 reference

12 December 2020

Immunohistochemical markers for prognosis of average-risk pediatric medulloblastomas. The effect of apoptotic index, TrkC, and c-myc expression.

1 reference

12 December 2020

Differential transactivation by alternative EWS-FLI1 fusion proteins correlates with clinical heterogeneity in Ewing's sarcoma.

1 reference

12 December 2020

Large-scale transcriptional activity in chromosomes 21 and 22

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12 December 2020

Familial anaplastic ependymoma: evidence of loss of chromosome 22 in tumour cells

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12 December 2020

Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system.

1 reference

12 December 2020

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

1 reference

12 December 2020

Genetic alterations in pediatric high-grade astrocytomas.

1 reference

12 December 2020

A new member of the ETS family fused to EWS in Ewing tumors

1 reference

12 December 2020

Up-regulation of specific NF 1 gene transcripts in sporadic pilocytic astrocytomas.

1 reference

12 December 2020

Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array

1 reference

12 December 2020

Navigating gene expression using microarrays--a technology review

1 reference

12 December 2020

Biochemical evidence that patched is the Hedgehog receptor

1 reference

12 December 2020

Prevalence of somatic alterations in the colorectal cancer cell genome

1 reference

12 December 2020

REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma

1 reference

12 December 2020

Incidence of p14ARF gene deletion in high-grade adult and pediatric astrocytomas.

1 reference

12 December 2020

Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood: definition of an entity

1 reference

12 December 2020

Allelic imbalance analysis by high-density single-nucleotide polymorphic allele (SNP) array with whole genome amplified DNA.

1 reference

12 December 2020

Medulloblastoma growth inhibition by hedgehog pathway blockade

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12 December 2020

p53 mutations in human tumors with chimericEWS/FLI/1 genes

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12 December 2020

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

1 reference

12 December 2020

Aberrant expression of tumor suppressor proteins in the Ewing family of tumors

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12 December 2020

Clinical correlations of genetic changes by comparative genomic hybridization in Ewing sarcoma and related tumors

1 reference

12 December 2020

Mutational analysis of the tyrosine phosphatome in colorectal cancers

1 reference

12 December 2020

Determination of p53 mutations, EGFR overexpression, and loss of p16 expression in pediatric glioblastomas.

1 reference

12 December 2020

Molecular insight into medulloblastoma and central nervous system primitive neuroectodermal tumor biology from hereditary syndromes: a review

1 reference

12 December 2020

GLI3 is not mutated commonly in sporadic medulloblastomas.

1 reference

12 December 2020

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

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12 December 2020

Identification of novel regions of allelic loss in ependymomas by high-resolution allelotyping with 384 microsatellite markers.

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12 December 2020

Inhibition of apoptosis by normal and aberrant Fli-1 and erg proteins involved in human solid tumors and leukemias

1 reference

12 December 2020

The molecular basis of Turcot's syndrome

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12 December 2020

Radial glia cells are candidate stem cells of ependymoma

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12 December 2020

Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome

1 reference

12 December 2020

Analysis of pilocytic astrocytoma by comparative genomic hybridization.

1 reference

12 December 2020

Chromosomes in the genesis and progression of ependymomas.

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12 December 2020

Chromosomes in Ewing's sarcoma. II. Nonrandom additional changes, trisomy 8 and der(16)t(1;16)

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12 December 2020

Identification of a novel homozygous deletion region at 6q23.1 in medulloblastomas using high-resolution array comparative genomic hybridization analysis

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12 December 2020

Insulin-like growth factor I receptor activity in human medulloblastomas.

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12 December 2020

Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease

1 reference

12 December 2020

Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system

1 reference

12 December 2020

Intracranial malignant germ cell tumor and the Klinefelter syndrome. Case report and review of the literature

1 reference

12 December 2020

Molecular cytogenetic studies of pediatric ependymomas

1 reference

12 December 2020

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

1 reference

12 December 2020

Deletion of chromosome arm 17p DNA sequences in pediatric high-grade and juvenile pilocytic astrocytomas.

1 reference

12 December 2020

Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma

1 reference

12 December 2020

Frequency and implications of chromosome 8 and 12 gains in Ewing sarcoma

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12 December 2020

Familial posterior fossa brain tumors of infancy secondary to germline mutation of the hSNF5 gene

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12 December 2020

High density synthetic oligonucleotide arrays

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12 December 2020

Microsatellite instability occurs in distinct subtypes of pediatric but not adult central nervous system tumors

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12 December 2020

Integrative analysis of the cancer transcriptome

1 reference

12 December 2020

Nuclear localization and mutation of beta-catenin in medulloblastomas

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12 December 2020

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

1 reference

12 December 2020

A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG

1 reference

12 December 2020

Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors

1 reference

12 December 2020

A tumor profile in Down syndrome.

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12 December 2020

Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma.

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12 December 2020

Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II.

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12 December 2020

Age and TP53 mutation frequency in childhood malignant gliomas: results in a multi-institutional cohort.

1 reference

12 December 2020

DNA-microarray analysis of brain cancer: molecular classification for therapy

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12 December 2020

Novel RNAs identified from an in-depth analysis of the transcriptome of human chromosomes 21 and 22

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12 December 2020

A tiling resolution DNA microarray with complete coverage of the human genome

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12 December 2020

Comparison of microsatellites versus single-nucleotide polymorphisms in a genome linkage screen for prostate cancer-susceptibility Loci

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12 December 2020

Preferential inactivation of the p53 tumor suppressor pathway and lack of EGFR amplification distinguish de novo high grade pediatric astrocytomas from de novo adult astrocytomas

1 reference

12 December 2020

Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.

1 reference

12 December 2020

PTEN mutations in gliomas and glioneuronal tumors.

1 reference

12 December 2020

Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice

1 reference

12 December 2020

Prediction of central nervous system embryonal tumour outcome based on gene expression

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12 December 2020

beta-catenin signaling and cancer

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12 December 2020

PDGFRB is overexpressed in metastatic medulloblastoma

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12 December 2020

Are juvenile pilocytic astrocytomas benign tumors? A cytogenetic study in 24 cases.

1 reference

12 December 2020

The ETS oncogene family in development, proliferation and neoplasia

1 reference

12 December 2020

Fundamentals of DNA hybridization arrays for gene expression analysis

1 reference

12 December 2020

The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains

1 reference

12 December 2020

EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells

1 reference

12 December 2020

Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event.

1 reference

12 December 2020

A set of BAC clones spanning the human genome

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12 December 2020

CGH analysis of secondary genetic changes in Ewing tumors: correlation with metastatic disease in a series of 43 cases

1 reference

12 December 2020

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.

1 reference

12 December 2020

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

1 reference

12 December 2020

Genome-wide association study in esophageal cancer using GeneChip mapping 10K array

1 reference

12 December 2020

Array CGH technologies and their applications to cancer genomes

1 reference

12 December 2020

Comparative genomic hybridization in pineal germ cell tumors

1 reference

12 December 2020

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.

1 reference

12 December 2020

Profiling and functional annotation of mRNA gene expression in pediatric rhabdomyosarcoma and Ewing's sarcoma

1 reference

12 December 2020

Lung cancer: intragenic ERBB2 kinase mutations in tumours

1 reference

12 December 2020

Monitoring gene expression using DNA microarrays

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12 December 2020

Detection of oncogene amplifications in medulloblastomas by comparative genomic hybridization and array-based comparative genomic hybridization

1 reference

12 December 2020

Loss of neurofibromatosis 1 (NF1) gene expression in NF1-associated pilocytic astrocytomas.

1 reference

12 December 2020

Expression of the neurotrophin receptor p75NTR in medulloblastomas is correlated with distinct histological and clinical features: evidence for a medulloblastoma subtype derived from the external granule cell layer

1 reference

12 December 2020

Molecular genetic analysis of chromosome arm 17p and chromosome arm 22q DNA sequences in sporadic pediatric ependymomas

1 reference

12 December 2020

Molecular pathogenesis of astrocytic tumours

1 reference

12 December 2020

Expression of the ErbB-neuregulin signaling network during human cerebellar development: implications for the biology of medulloblastoma.

1 reference

12 December 2020

Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma development.

1 reference

12 December 2020

Large-scale genotyping of complex DNA.

1 reference

12 December 2020

Mutations in SUFU predispose to medulloblastoma

1 reference

12 December 2020

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

1 reference

12 December 2020

Newly defined central nervous system neoplasms

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12 December 2020

Bioinformatics in neurosurgery

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12 December 2020

Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma

1 reference

12 December 2020

Primary Ewing's sarcoma of the skull in children. Utility of molecular diagnostics, surgery and adjuvant therapies

1 reference

12 December 2020

The relationship between TP53 mutations and overexpression of p53 and prognosis in malignant gliomas of childhood.

1 reference

12 December 2020

Microarray analysis of pediatric ependymoma identifies a cluster of 112 candidate genes including four transcripts at 22q12.1-q13.3

1 reference

12 December 2020

10.1007/S00381-006-0187-3

Identifiers

DOI

1 reference

15 August 2017

1 reference