(Q36585151)

English

Prediction of clinical outcome of fluoropyrimidine-based chemotherapy for gastric cancer patients, in terms of the 5-fluorouracil metabolic pathway

scientific article published on January 2006

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scholarly article

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

Prediction of clinical outcome of fluoropyrimidine-based chemotherapy for gastric cancer patients, in terms of the 5-fluorouracil metabolic pathway (English)

1 reference

Europe PubMed Central

15 August 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Wataru Ichikawa

1

1 reference

Europe PubMed Central

15 August 2017

publication date

1 January 2006

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

9

1 reference

Europe PubMed Central

15 August 2017

145-155

1 reference

Europe PubMed Central

15 August 2017

3

1 reference

Europe PubMed Central

15 August 2017

https://scigraph.springernature.com/pub.10.1007/s10120-006-0373-8

0 references

Dihydropyrimidine dehydrogenase and messenger RNA levels in gastric cancer: possible predictor for sensitivity to 5-fluorouracil.

1 reference

https://api.crossref.org/works/10.1007%2FS10120-006-0373-8

21 January 2018

Sensitivity of human, murine, and rat cells to 5-fluorouracil and 5'-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recurrence and 5-FU sensitivity of stage II/III node-positive gastric cancer with occult neoplastic cells in lymph node sinuses

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidylate synthetase and dihydropyrimidine dehydrogenase levels in gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dihydropyrimidine dehydrogenase activity and mRNA expression in advanced gastric cancer analyzed in relation to effectiveness of preoperative 5-fluorouracil-based chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical implications of immunoreactivity of thymidylate synthase and dihydropyrimidine dehydrogenase in gastric cancer treated with oral fluoropyrimidine (S-1). Study Group of S-1 for Gastric Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic role of thymidylate synthase polymorphisms in gastric cancer patients treated with surgery and adjuvant chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolving chemotherapy for advanced gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidylate Synthase expression as a predictor of clinical response to fluoropyrimidine-based chemotherapy in advanced colorectal cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: preliminary report from an ongoing trial.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Schedule-dependent inhibition of thymidylate synthase by 5-fluorouracil in gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer pharmacogenetics: polymorphisms, pathways and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase, E2F-1, Bak, Bcl-X, and Bcl-2, and clinical outcomes for gastric cancer patients treated with bolus 5-fluorouracil

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in relation to differentiation of gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production and characterization of monoclonal antibodies that localize human thymidylate synthase in the cytoplasm of human cells and tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of thymidylate synthase and dihydropyrimidine dehydrogenase in tumor progression and sensitivity to 5-fluorouracil in human gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidine phosphorylase expression correlates with malignant potential and anti-tumor effect of doxifluridine on gastric cancer: multivariate analysis for adjuvant chemotherapy doxifluridine vs. 5-fluorouracil.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variance in the expression of 5-Fluorouracil pathway genes in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological markers as a predictor for response and prognosis of unresectable gastric cancer patients treated with 5-fluorouracil and cis-platinum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of dihydropyrimidine dehydrogenase in cancer cells but not in stromal cells predicts the efficacy of fluorouracil treatment in patients with gastric carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of thymidylate synthase and thymidine phosphorylase in recurrence and survival rates of advanced gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superior antitumour activity of S-1 in tumours with a high dihydropyrimidine dehydrogenase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical evaluation of thymidylate synthase in gastric carcinoma using a new polyclonal antibody: the clinical role of thymidylate synthase as a prognostic indicator and its therapeutic usefulness.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidine phosphorylase: its role in sensitivity and resistance to anticancer drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic factors influencing pyrimidine-antagonist chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationships between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase and cell proliferative activity and 5-fluorouracil sensitivity in colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dihydropyrimidine dehydrogenase expression in preoperative biopsy and surgically resected specimens of gastric carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ribose 1-phosphate metabolism in Ehrlich ascites tumor cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of the response of colorectal cancer to systemic therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dihydropyrimidine dehydrogenase (DPD) activity in gastric cancer tissue and effect of DPD inhibitory fluoropyrimidines

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of S-1, a novel oral derivative of 5-fluorouracil, in advanced gastric cancer. For the S-1 Cooperative Gastric Cancer Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High expression of thymidylate synthase is associated with the drug resistance of gastric carcinoma to high dose 5-fluorouracil-based systemic chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidylate synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of response to 5'-deoxy-5-fluorouridine (5'-DFUR) in patients with inoperable advanced gastric cancer by immunostaining of thymidine phosphorylase/platelet-derived endothelial cell growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidine phosphorylase (platelet-derived endothelial-cell growth factor) in cancer biology and treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tailoring chemotherapy in advanced colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidylate synthetase (TS) genotype and TS/dihydropyrimidine dehydrogenase mRNA level as an indicator in determining chemosensitivity to 5-fluorouracil in advanced gastric carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS)--novel predictors for response and survival in gastric cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer pharmacogenetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical application of immunoreactivity of dihydropyrimidine dehydrogenase (DPD) in gastric scirrhous carcinoma treated with S-1, a new DPD inhibitory fluoropyrimidine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidylate synthetase - a target enzyme in cancer chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low thymidylate synthase expression in the primary tumor predicts favorable clinical outcome in resected gastric cancer patients treated with adjuvant tegafur

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorouracil: biochemistry and pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidine phosphorylase expression is useful in selecting adjuvant chemotherapy for stage III gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of thymidylate synthase in relation to survival and chemosensitivity in gastric cancer patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined GADD45A and thymidine phosphorylase expression levels predict response and survival of neoadjuvant-treated gastric cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase in tumour tissues of patients with metastatic gastric cancer is predictive of the clinical response to 5'-deoxy-5-fluorouridine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is the measurement of thymidylate synthase to determine suitability for treatment with 5-fluoropyrimidines ready for prime time?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current status and future prospects of chemotherapy for metastatic gastric cancer: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dihydropyrimidine dehydrogenase-related enzymes predict efficacy and adverse reactions of UFT1+cisplatin neoadjuvant chemotherapy for gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Fluorouracil: mechanisms of action and clinical strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Fluorouracil and UFT-sensitive gastric carcinoma has a high level of thymidylate synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of thymidine phosphorylase and dihydropyrimidine dehydrogenase in tumour progression and sensitivity to doxifluridine in gastric cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16952032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10120-006-0373-8

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

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