(Q36610082)

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Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner

scientific article published on 19 April 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Hedgehog Dmel_CG4637

1 reference

GOA release 2020-03-11

Smoothened Dmel_CG11561

1 reference

GOA release 2020-03-11

Costa Dmel_CG1708

1 reference

GOA release 2020-03-11

phosphorylation

1 reference

based on heuristic

inferred from title

author name string

Junkai Fan

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Yajuan Liu

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Jianhang Jia

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

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publication date

19 April 2012

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Europe PubMed Central

PMC publication ID

15 August 2017

number of pages

13

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inferred from page(s)

Developmental Biology

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Europe PubMed Central

PMC publication ID

15 August 2017

366

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

172-184

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

Sequential phosphorylation of smoothened transduces graded hedgehog signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened

1 reference

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30 September 2017

Mechanisms and functions of Hedgehog signalling across the metazoa

1 reference

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30 September 2017

Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus

1 reference

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30 September 2017

Genetic and biochemical definition of the Hedgehog receptor

1 reference

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30 September 2017

Hedgehog signaling in development and cancer.

1 reference

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30 September 2017

The role of kinases in the Hedgehog signalling pathway

1 reference

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30 September 2017

Hedgehog regulates smoothened activity by inducing a conformational switch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation

1 reference

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30 September 2017

An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases

1 reference

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30 September 2017

P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster.

1 reference

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30 September 2017

Decoding the Hedgehog signal in animal development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

Communicating with Hedgehogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

The Hedgehog response network: sensors, switches, and routers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

Hedgehog signaling in animal development: paradigms and principles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

Transducing the Dpp morphogen gradient in the wing of Drosophila: regulation of Dpp targets by brinker

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3572470

30 September 2017

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1 reference

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30 September 2017

Sonic hedgehog mediates the polarizing activity of the ZPA

1 reference

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Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein

1 reference

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Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1 reference

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30 September 2017

G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

1 reference

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28 June 2018

PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation

1 reference

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28 June 2018

Protein kinase A and hedgehog signaling in Drosophila limb development

1 reference

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28 June 2018

Distinct phosphorylations on kinesin costal-2 mediate differential hedgehog signaling strength.

1 reference

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20 September 2018

A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing.

1 reference

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20 September 2018

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing.

1 reference

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20 September 2018

Direct and long-range action of a DPP morphogen gradient.

1 reference

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The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways

1 reference

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20 September 2018

Identifiers

10.1016/J.YDBIO.2012.04.007

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

ResearchGate publication ID

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