(Q52733810)

6 May 2018

title

Distinct Phosphorylations on Kinesin Costal-2 Mediate Differential Hedgehog Signaling Strength (English)

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

24 December 2024

1 reference

Cubitus interruptus Dmel_CG2125

1 reference

Smoothened Dmel_CG11561

1 reference

Fused Dmel_CG6551

1 reference

Patched Dmel_CG2411

1 reference

G protein-coupled receptor kinase 2 Dmel_CG17998

1 reference

Costa Dmel_CG1708

1 reference

5

Pascal P. Thérond

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A22306085

24 December 2024

author name string

Nadia Ranieri

1

1 reference

6 May 2018

Laurent Ruel

2

1 reference

6 May 2018

Armel Gallet

3

1 reference

6 May 2018

Sophie Raisin

4

1 reference

6 May 2018

language of work or name

English

0 references

publication date

2 February 2012

1 reference

6 May 2018

full work available at URL

number of pages

16

1 reference

based on heuristic

inferred from page(s)

http://www.cell.com/article/S1534580711005685/pdf

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A22306085

https://api.elsevier.com/content/article/PII:S1534580711005685?httpAccept=text/xml

24 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

https://api.elsevier.com/content/article/PII:S1534580711005685?httpAccept=text/plain

24 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

24 December 2024

1 reference

6 May 2018

volume

22

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6 May 2018

issue

2

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6 May 2018

page(s)

279-294

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6 May 2018

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins

cites work

1

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

24 December 2024

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https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Dual roles for patched in sequestering and transducing Hedgehog

24 December 2024

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https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression

24 December 2024

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https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

24 December 2024

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Regulation of smoothened by Drosophila G-protein-coupled receptor kinases

24 December 2024

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Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused.

24 December 2024

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Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

24 December 2024

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Lipoprotein-heparan sulfate interactions in the Hh pathway

24 December 2024

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A quantification of pathway components supports a novel model of Hedgehog signal transduction

24 December 2024

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Protein interaction mapping: a Drosophila case study

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Smoothened translates Hedgehog levels into distinct responses

24 December 2024

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Hedgehog signaling in animal development: paradigms and principles

24 December 2024

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Role of the Drosophila patched gene in positional signalling

24 December 2024

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Decoding the Hedgehog signal in animal development.

24 December 2024

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Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

24 December 2024

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Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

24 December 2024

18

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https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus

24 December 2024

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Hedgehog signaling in development and cancer.

24 December 2024

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https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation

24 December 2024

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Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

24 December 2024

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Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation

24 December 2024

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Dynamic interpretation of hedgehog signaling in the Drosophila wing disc

24 December 2024

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Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused

24 December 2024

26

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2

24 December 2024

27

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling

24 December 2024

29

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2

24 December 2024

30

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

24 December 2024

31

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling

24 December 2024

32

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

24 December 2024

33

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway

24 December 2024

34

1 reference

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Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation.

24 December 2024

35

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Patched acts catalytically to suppress the activity of Smoothened

24 December 2024

36

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Molecular organisation and expression pattern of the segment polarity gene fused of Drosophila melanogaster.

24 December 2024

37

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Phosphorylation of the fused protein kinase in response to signaling from hedgehog

24 December 2024

38

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Hedgehog: functions and mechanisms

24 December 2024

39

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms

24 December 2024

41

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

24 December 2024

42

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

24 December 2024

43

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

24 December 2024

44

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus

24 December 2024

45

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Hedgehog regulates smoothened activity by inducing a conformational switch

24 December 2024

46

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

Hedgehog Activates Fused through Phosphorylation to Elicit a Full Spectrum of Pathway Responses

24 December 2024

47

1 reference

https://api.crossref.org/works/10.1016/J.DEVCEL.2011.12.002

24 December 2024

Identifiers

1 reference

6 May 2018

1 reference

6 May 2018