(Q36638798)

15 August 2017

Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13. (English)

1 reference

15 August 2017

1 reference

GOA release 2020-03-11

Kohtalo Dmel_CG8491

1 reference

GOA release 2020-03-11

Skuld Dmel_CG9936

1 reference

GOA release 2020-03-11

Inés Carrera

1

0 references

Florence Janody

object named as

Florence Janody

2

0 references

Jessica E Treisman

object named as

Jessica E Treisman

5

0 references

author name string

Nina Leeds

3

1 reference

PMCID

2373359

15 August 2017

Fabien Duveau

4

1 reference

PMCID

2373359

15 August 2017

language of work or name

English

0 references

publication date

1 May 2008

1 reference

Proceedings of the National Academy of Sciences of the United States of America

15 August 2017

1 reference

15 August 2017

105

1 reference

15 August 2017

6644-6649

1 reference

15 August 2017

18

1 reference

Transcriptional control of cell-cycle quiescence during C. elegans development

15 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

CDK8 is a stimulus-specific positive coregulator of p53 target genes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Distinct roles for Mediator Cdk8 module subunits in Drosophila development.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A subunit of the mediator complex regulates vertebrate neuronal development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Mediator modulates Gli3-dependent Sonic hedgehog signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A Mediator-responsive form of metazoan RNA polymerase II.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Transcription under the control of nuclear Arm/beta-catenin.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Genome-wide location of the coactivator mediator: Binding without activation and transient Cdk8 interaction on DNA.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The mammalian Mediator complex and its role in transcriptional regulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Interactions between subunits of Drosophila Mediator and activator proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The yeast Mediator complex and its regulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Functional genomic analysis of the Wnt-wingless signaling pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Mediator requirement for both recruitment and postrecruitment steps in transcription initiation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Identification and in vivo role of the Armadillo-Legless interaction.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Ras induces mediator complex exchange on C/EBP beta

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Pygopus residues required for its binding to Legless are critical for transcription and development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Transcriptional activating regions target a cyclin-dependent kinase.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A component of the ARC/Mediator complex required for TGF beta/Nodal signalling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

pygopus Encodes a nuclear protein essential for wingless/Wnt signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Repression of Teashirt marks the initiation of wing development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Structure, function, and activator-induced conformations of the CRSP coactivator

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

TFIIH is negatively regulated by cdk8-containing mediator complexes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Srb/mediator proteins interact functionally and physically with transcriptional repressor Sfl1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

SSN genes that affect transcriptional repression in Saccharomyces cerevisiae encode SIN4, ROX3, and SRB proteins associated with RNA polymerase II

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A kinase-cyclin pair in the RNA polymerase II holoenzyme.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Proximal-distal axis formation in the Drosophila leg.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Direct and long-range action of a wingless morphogen gradient.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

wingless refines its own expression domain on the Drosophila wing margin.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Transcription of the segment-polarity gene wingless in the imaginal discs of Drosophila, and the phenotype of a pupal-lethal wg mutation

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Association of an activator with an RNA polymerase II holoenzyme.

28 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Two subunits of the Drosophila mediator complex act together to control cell affinity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

A complex of Armadillo, Legless, and Pygopus coactivates dTCF to activate wingless target genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Differing strategies for the establishment and maintenance of teashirt and homothorax repression in the Drosophila wing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Antagonistic interactions between wingless and decapentaplegic responsible for dorsal-ventral pattern in the Drosophila Leg.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Direct and long-range action of a DPP morphogen gradient.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Wingless-independent association of Pygopus with dTCF target genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Mediator is a transducer of Wnt/beta-catenin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

The Ras/PKA signaling pathway directly targets the Srb9 protein, a component of the general RNA polymerase II transcription apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Control of a genetic regulatory network by a selector gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

GAL4 Is Regulated by the RNA Polymerase II Holoenzyme–Associated Cyclin-Dependent Protein Kinase SRB10/CDK8

20 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18451032

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0709749105

1 reference

15 August 2017

0 references

1 reference

15 August 2017

1 reference

PMCID

2373359