(Q36647405)

15 August 2017

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title

Protein oxidation and degradation during aging: role in skin aging and neurodegeneration (English)

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15 August 2017

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Rebecca Widmer

1

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15 August 2017

Isabella Ziaja

series ordinal

2

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15 August 2017

Tilman Grune

series ordinal

3

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15 August 2017

publication date

1 December 2006

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15 August 2017

published in

Free Radical Research

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15 August 2017

volume

40

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15 August 2017

issue

12

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15 August 2017

page(s)

1259-1268

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An attempt at a rational classification of theories of ageing

15 August 2017

cites work

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

21 January 2018

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Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes

21 January 2018

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Macroxyproteinase (M.O.P.): a 670 kDa proteinase complex that degrades oxidatively denatured proteins in red blood cells.

21 January 2018

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Exposure of hydrophobic moieties promotes the selective degradation of hydrogen peroxide-modified hemoglobin by the multicatalytic proteinase complex, proteasome

21 January 2018

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Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome.

21 January 2018

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Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome.

21 January 2018

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Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome

21 January 2018

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Comparative resistance of the 20S and 26S proteasome to oxidative stress.

21 January 2018

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Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome.

21 January 2018

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Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts

21 January 2018

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Aggresomes: a cellular response to misfolded proteins

21 January 2018

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Protein aggregation: folding aggregates, inclusion bodies and amyloid

21 January 2018

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Mutations and off-pathway aggregation of proteins

21 January 2018

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Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores

21 January 2018

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Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival

21 January 2018

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https://api.crossref.org/works/10.1080%2F10715760600911154

Ultraviolet A radiation-induced biological effects in human skin: relevance for photoaging and photodermatosis

21 January 2018

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https://api.crossref.org/works/10.1080%2F10715760600911154

Tight control of matrix metalloproteinase-1 activity in human skin

21 January 2018

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https://api.crossref.org/works/10.1080%2F10715760600911154

Pathophysiology of premature skin aging induced by ultraviolet light

21 January 2018

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Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo

21 January 2018

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Retinoids interfere with the AP1 signalling pathway in human breast cancer cells.

21 January 2018

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Prevention of the ultraviolet B-mediated skin photoaging by a nuclear factor kappaB inhibitor, parthenolide

21 January 2018

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Role of redox-regulated transcription factors in inflammation, aging and age-related diseases

21 January 2018

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21 January 2018

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Topical application of alpha-tocopherol modulates the antioxidant network and diminishes ultraviolet-induced oxidative damage in murine skin

21 January 2018

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https://api.crossref.org/works/10.1080%2F10715760600911154

Impairment of proteasome function upon UVA- and UVB-irradiation of human keratinocytes

21 January 2018

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https://api.crossref.org/works/10.1080%2F10715760600911154

Historical claims and current interpretations of replicative aging

21 January 2018

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https://api.crossref.org/works/10.1080%2F10715760600911154

Oxidative stress in cell culture: an under-appreciated problem?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Carbonyl assays for determination of oxidatively modified proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I--effects of proliferative senescence

21 January 2018

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https://api.crossref.org/works/10.1080%2F10715760600911154

Hydrogen peroxide-mediated protein oxidation in young and old human MRC-5 fibroblasts.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10715760600911154

Aggregates of oxidized proteins (lipofuscin) induce apoptosis through proteasome inhibition and dysregulation of proapoptotic proteins

21 January 2018

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Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion

21 January 2018

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https://api.crossref.org/works/10.1080%2F10715760600911154

Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Proteasome inhibition induces a senescence-like phenotype in primary human fibroblasts cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Oxidative modification of proteins during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Protein oxidation in aging, disease, and oxidative stress

21 January 2018

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https://api.crossref.org/works/10.1080%2F10715760600911154

Protein oxidation and aging

21 January 2018

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https://api.crossref.org/works/10.1080%2F10715760600911154

Oxidative stress and neurodegeneration: where are we now?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Brain iron deposition and the free radical-mitochondrial theory of ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Age influence on oxidative events during brain ischemia/reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Iron-induced lipid peroxidation and inhibition of dopamine synthesis in striatum synaptosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Regional lipid peroxidation in rat brain in vitro: possible role of endogenous iron.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Delaying the mitochondrial decay of aging with acetylcarnitine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Delaying the mitochondrial decay of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Proteasome inhibition by MG-132 induces apoptotic cell death and mitochondrial dysfunction in cultured rat brain oligodendrocytes but not in astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

LMP2 knock-out mice have reduced proteasome activities and increased levels of oxidatively damaged proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Gene expression profile of aging and its retardation by caloric restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Mitotic misregulation and human aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Subunits of the regulatory complex of the 26S protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

A TrkA-to-p75NTR molecular switch activates amyloid beta-peptide generation during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Ubiquitin is a component of paired helical filaments in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Neuritic pathology and dementia in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Oxidative stress hypothesis in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

4-Hydroxynonenal-modified amyloid-beta peptide inhibits the proteasome: possible importance in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

The NF-kappa B and I kappa B proteins: new discoveries and insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Microglia in degenerative neurological disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Nuclear and mitochondrial genetics in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

alpha-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Attenuation of dopamine transporter activity by alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

The ubiquitin pathway in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Proteasomal inhibition by alpha-synuclein filaments and oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Protein nitration in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

Studies on age pigments evolving into a new theory of biological aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760600911154

10.1080/10715760600911154

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference