(Q45025020)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15322100%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

title

alpha-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15322100%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

main subject

protein ubiquitination

1 reference

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15322100%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

author name string

Hardy J Rideout

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15322100%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Paula Dietrich

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15322100%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Qiaohong Wang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15322100%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Leonidas Stefanis

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15322100%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

language of work or name

English

0 references

publication date

18 August 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15322100%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

31 December 2019

published in

1 reference

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31 December 2019

volume

279

1 reference

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31 December 2019

issue

45

1 reference

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31 December 2019

page(s)

46915-46920

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15322100%20AND%20SRC:MED&resulttype=core&format=json

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

31 December 2019

cites work

1 reference

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

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The ubiquitin pathway in Parkinson's disease.

21 January 2018

1 reference

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

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The ubiquitin-proteasome pathway: on protein death and cell life

21 January 2018

1 reference

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Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex

21 January 2018

1 reference

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Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

21 January 2018

1 reference

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Proteasomal inhibition by alpha-synuclein filaments and oligomers.

21 January 2018

1 reference

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Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

1 reference

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Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

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Neurobiology of alpha-synuclein

21 January 2018

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Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

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Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

21 January 2018

1 reference

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Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture

21 January 2018

1 reference

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Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Proteasomal function is impaired in substantia nigra in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Lack of p53 delays apoptosis, but increases ubiquitinated inclusions, in proteasomal inhibitor-treated cultured cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Regulation of alpha-synuclein by bFGF in cultured ventral midbrain dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Lactacystin, proteasome function, and cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Effects of macromolecular crowding on protein folding and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Accelerated alpha-synuclein fibrillation in crowded milieu

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

Induction of neuronal death by α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405146200

21 January 2018

Identifiers

DOI

10.1074/JBC.M405146200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15322100%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference