(Q36647438)

English

Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases

scientific article published on December 2006

In more languages

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scholarly article

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases (English)

1 reference

Europe PubMed Central

15 August 2017

author name string

Ioannis P Trougakos

1

1 reference

Europe PubMed Central

15 August 2017

Efstathios S Gonos

2

1 reference

Europe PubMed Central

15 August 2017

publication date

1 December 2006

1 reference

Europe PubMed Central

15 August 2017

Free Radical Research

1 reference

Europe PubMed Central

15 August 2017

40

1 reference

Europe PubMed Central

15 August 2017

12

1 reference

Europe PubMed Central

15 August 2017

1324-1334

1 reference

Europe PubMed Central

15 August 2017

Clusterin/apolipoprotein J in human aging and cancer

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Apolipoprotein J: structure and tissue distribution

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Apolipoprotein J expression at fluid-tissue interfaces: potential role in barrier cytoprotection

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Identification and characterization of glycosylation sites in human serum clusterin

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Alterations in the post-translational modification and intracellular trafficking of clusterin in MCF-7 cells during apoptosis

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin inhibits apoptosis by interacting with activated Bax

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Nuclear clusterin accumulation during heat shock response: implications for cell survival and thermo-tolerance induction in immortalized and prostate cancer cells

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Expression of multiple forms of clusterin during light-induced retinal degeneration

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Modification of the alternative splicing process of testosterone-repressed prostate message-2 (TRPM-2) gene by protein synthesis inhibitors and heat shock treatment.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Effect of heat shock treatment on the production of variant testosterone-repressed prostate message-2 (TRPM-2) mRNA in culture cells

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Synthesis and functional analyses of nuclear clusterin, a cell death protein

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

V-src-induced-transcription of the avian clusterin gene

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Regulation of clusterin gene expression by transforming growth factor beta

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Stress-induced transcription of the clusterin/apoJ gene.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin, a binding protein with a molten globule-like region

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Evidence that clusterin has discrete chaperone and ligand binding sites.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin is a secreted mammalian chaperone

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Multiple receptors mediate apoJ-dependent clearance of cellular debris into nonprofessional phagocytes

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Induction of the TRPM-2 gene in cells undergoing programmed death

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin levels increase during neuronal development.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Developmental expression of sulfated glycoprotein-2 in the epididymis of the rat.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin promotes the aggregation and adhesion of renal porcine epithelial cells

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Identification of clusterin sequences mediating renal tubular cell interactions

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Essential requirement of apolipoprotein J (clusterin) signaling for IkappaB expression and regulation of NF-kappaB activity.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin (SGP-2) gene expression is cell cycle dependent in normal human dermal fibroblasts.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin gene expression mediates resistance to apoptotic cell death induced by heat shock and oxidative stress

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Differential effects of clusterin/apolipoprotein J on cellular growth and survival.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Apolipoprotein J and Alzheimer's amyloid beta solubility

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Cellular response to oxidative stress: signaling for suicide and survival

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Role of oxygen radicals in DNA damage and cancer incidence.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Reactive oxygen species in tumor progression

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Free radicals, metals and antioxidants in oxidative stress-induced cancer

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Adaptive mechanisms to oxidative stress during aging

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Impairment of proteasome structure and function in aging.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Proteasome dysfunction in mammalian aging: steps and factors involved

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Proteasomal defense of oxidative protein modifications.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Dynamic remodeling of transcription complexes by molecular chaperones

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Molecular chaperones as regulatory elements of cellular networks

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Oxidative stress and cell cycle checkpoint function.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Redox-regulated molecular chaperones

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Evolution of ageing

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Causes of aging

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Oxidants, oxidative stress and the biology of ageing

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Oxidative stress and aging: beyond correlation

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Free radicals in the physiological control of cell function

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Cancer and ageing: rival demons?

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Genetics and the specificity of the aging process

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Apoptosis and aging: role of p66Shc redox protein.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

p66ShcA and ageing: modulation by longevity-promoting agent aurintricarboxylic acid.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Deletion of p66shc gene protects against age-related endothelial dysfunction

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

The power and the promise of oncogene-induced senescence markers.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Redox control of 20S proteasome.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Experimental study of oxidative DNA damage

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Role of oxidative modifications in atherosclerosis

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Free radicals and aging.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Dynamics of free radical processes in acute ischemic stroke: influence on neurological status and outcome

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Oxidative stress in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Oxidative stress and redox-active iron in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Alzheimer's disease: the two-hit hypothesis

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Amyloidogenicity of rodent and human beta A4 sequences.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

In vitro polymerization of oxidized tau into filaments.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Oxidative stress and cytoskeletal alterations

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression, a pro-survival factor.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxide

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Protection of androgen-dependent human prostate cancer cells from oxidative stress-induced DNA damage by overexpression of clusterin and its modulation by androgen

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin overexpression in both malignant and nonmalignant prostate epithelial cells induces cell cycle arrest and apoptosis

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Intracellular clusterin induces G2-M phase arrest and cell death in PC-3 prostate cancer cells1.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Cloning and identification of genes that associate with mammalian replicative senescence

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Alterations of senescence biomarkers in human cells by exposure to CrVI in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Ca2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Intracellular clusterin causes juxtanuclear aggregate formation and mitochondrial alteration

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Overexpression of the cytoprotective protein clusterin decreases radiosensitivity in the human LNCaP prostate tumour model

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin regulates drug-resistance in melanoma cells

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Oncogenic role of clusterin overexpression in multistage colorectal tumorigenesis and progression

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Apolipoprotein J/clusterin prevents a progressive glomerulopathy of aging

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Heat shock-initiated apoptosis is accelerated and removal of damaged cells is delayed in the testis of clusterin/ApoJ knock-out mice

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Antisense oligodeoxynucleotide therapy targeting clusterin gene for prostate cancer: Vancouver experience from discovery to clinic

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Age-dependent increase of clusterin in the human pituitary gland.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Age-Associated Changes in Histology and Gene-Expression Profile in the Rat Ventral Prostate

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Progressive changes in regulation of apolipoproteins E and J in glial cultures during postnatal development and aging.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin (SGP-2, ApoJ) expression is downregulated in low- and high-grade human prostate cancer.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Loss of clusterin both in serum and tissue correlates with the tumorigenesis of esophageal squamous cell carcinoma via proteomics approaches.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Overexpression of clusterin in human breast carcinoma

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin as a biomarker in murine and human intestinal neoplasia

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Modulation of different clusterin isoforms in human colon tumorigenesis

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin: a protective mediator for ischemic cardiomyocytes?

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Purification and characterization of brain clusterin

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Deposition of apolipoproteins E and J in senile plaques is topographically determined in both Alzheimer's disease and Down's syndrome brain

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin (apoJ) alters the aggregation of amyloid beta-peptide (A beta 1-42) and forms slowly sedimenting A beta complexes that cause oxidative stress.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Centenarians as a model for healthy aging

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Small heat shock proteins: molecular structure and chaperone function

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

On the role of Hsp27 in regulating apoptosis

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Aging and molecular chaperones

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Expression of alpha B-crystallin in human brain tumors.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Overexpression of Hsp27 affects the metastatic phenotype of human melanoma cells in vitro

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Expression of heat-shock proteins hsp27, hsp70 and hsp90 in malignant epithelial tumour of the ovaries.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

alphaB-crystallin as a marker of lymph node involvement in breast carcinoma

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Small heat shock proteins and protection against ischemic injury in cardiac myocytes

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Transgene overexpression of alphaB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Overexpression of wild-type heat shock protein 27 and a nonphosphorylatable heat shock protein 27 mutant protects against ischemia/reperfusion injury in a transgenic mouse model

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Alpha B crystallin and HSP28 are enhanced in the cerebral cortex of patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Expression of alpha B-crystallin in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Deranged expression of molecular chaperones in brains of patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

The small heat shock proteins and their role in human disease.

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin Has Chaperone-like Activity Similar to That of Small Heat Shock Proteins

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Clusterin plays an important role in hepatocellular carcinoma metastasis

1 reference

https://api.crossref.org/works/10.1080%2F10715760600902310

21 January 2018

Identifiers

10.1080/10715760600902310

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

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