(Q36652782)

15 August 2017

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title

Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas (English)

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15 August 2017

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Patricia L M Dahia

1

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15 August 2017

Familial Pheochromocytoma Consortium

series ordinal

2

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15 August 2017

language of work or name

English

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publication date

1 August 2006

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Annals of the New York Academy of Sciences

15 August 2017

number of pages

13

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based on heuristic

inferred from page(s)

published in

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15 August 2017

volume

1073

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15 August 2017

page(s)

208-220

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Germ-line mutations in nonsyndromic pheochromocytoma

15 August 2017

cites work

1 reference

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A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas

21 January 2018

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

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The von Hippel-Lindau Gene, Kidney Cancer, and Oxygen Sensing

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How oxygen makes its presence felt

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HIF-1 and tumor progression: pathophysiology and therapeutics

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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

21 January 2018

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Oxygen sensors and angiogenesis

21 January 2018

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 January 2018

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Functional consequences of a SDHB gene mutation in an apparently sporadic pheochromocytoma

21 January 2018

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Mitochondrial tumour suppressors: a genetic and biochemical update

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Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

21 January 2018

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Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions

21 January 2018

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

21 January 2018

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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

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JunD reduces tumor angiogenesis by protecting cells from oxidative stress

21 January 2018

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A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes

21 January 2018

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The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway

21 January 2018

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Direct evidence for expression of type II flavoprotein subunit in human complex II (succinate-ubiquinone reductase).

21 January 2018

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Promoter analysis of the human succinate dehydrogenase iron-protein gene--both nuclear respiratory factors NRF-1 and NRF-2 are required

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Hypoxia requires notch signaling to maintain the undifferentiated cell state

21 January 2018

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HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

21 January 2018

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HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

21 January 2018

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Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene

21 January 2018

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Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

21 January 2018

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

21 January 2018

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The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer

21 January 2018

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

21 January 2018

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Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

21 January 2018

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von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

21 January 2018

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Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans

21 January 2018

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Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

21 January 2018

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Malignant pheochromocytoma: current status and initiatives for future progress

21 January 2018

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SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1353.023

21 January 2018

Identifiers

DOI

10.1196/ANNALS.1353.023

1 reference

15 August 2017

1 reference