(Q36662853)

15 August 2017

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title

High-throughput in vitro profiling assays: lessons learnt from experiences at Novartis (English)

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15 August 2017

Bernard Faller

1

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15 August 2017

Jianling Wang

2

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15 August 2017

Alfred Zimmerlin

3

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15 August 2017

Leslie Bell

4

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15 August 2017

Jacques Hamon

5

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15 August 2017

Steven Whitebread

6

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15 August 2017

Kamal Azzaoui

7

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15 August 2017

Dejan Bojanic

8

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15 August 2017

Laszlo Urban

9

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15 August 2017

language of work or name

English

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publication date

1 December 2006

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Expert Opinion on Drug Metabolism & Toxicology

15 August 2017

published in

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15 August 2017

volume

2

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15 August 2017

issue

6

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15 August 2017

page(s)

823-833

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Physicochemical profiling (solubility, permeability and charge state).

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Accuracy of calculated pH-dependent aqueous drug solubility.

21 January 2018

1 reference

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Comparison of a miniaturized shake-flask solubility method with automated potentiometric acid/base titrations and calculated solubilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

High throughput physicochemical profiling for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

A high-throughput screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Improvement of "hit-to-lead" optimization by integration of in vitro HTS experimental models for early determination of pharmacokinetic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

In silico ADME/Tox: why models fail

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Immobilized-artificial-membrane chromatography: measurements of membrane partition coefficient and predicting drug membrane permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

PAMPA--a drug absorption in vitro model 13. Chemical selectivity due to membrane hydrogen bonding: in combo comparisons of HDM-, DOPC-, and DS-PAMPA models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Caco-2 permeability of weakly basic drugs predicted with the double-sink PAMPA pKa(flux) method.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Utility of recombinant cytochrome p450 enzymes: a drug metabolism perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

A historical overview of the heterologous expression of mammalian UDP-glucuronosyltransferase isoforms over the past twenty years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Canalicular and sinusoidal disposition of bilirubin mono- and diglucuronides in sandwich-cultured human and rat primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Complexities of glucuronidation affecting in vitro in vivo extrapolation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Hospital admissions resulting from preventable adverse drug reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--toward a consensus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: qualitative relationships, quantitative predictions, and the rank-order approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Drug-induced hepatotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

In vitro models to study hepatotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Principles of hematotoxicology: laboratory assessment and interpretation of data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

An Improved Bacterial Test System for the Detection and Classification of Mutagens and Carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Biomarkers of genetic damage for cancer epidemiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Mini mutagenicity test: a miniaturized version of the Ames test used in a prescreening assay for point mutagenesis assessment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Biological spectra analysis: Linking biological activity profiles to molecular structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

Erratum: Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure–activity relationship (QSAR) with the Abraham descriptors**This article has recently been awarded the Ebert Prize, given by the APhA for t

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.6.823

21 January 2018

Identifiers

DOI

10.1517/17425255.2.6.823

1 reference

15 August 2017

1 reference