(Q40659465)

22 September 2017

Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers (English)

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22 September 2017

Staffan Tavelin

1

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22 September 2017

Jan Taipalensuu

2

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22 September 2017

Lauri Söderberg

3

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22 September 2017

Rick Morrison

4

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22 September 2017

Saeho Chong

5

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22 September 2017

Per Artursson

6

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22 September 2017

1 March 2003

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22 September 2017

Pharmaceutical Research

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22 September 2017

20

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22 September 2017

3

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22 September 2017

397-405

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Effect of changing intestinal flow rate on a measurement of intestinal permeability

22 September 2017

1 reference

12 December 2020

Saturable transport of H2-antagonists ranitidine and famotidine across Caco-2 cell monolayers

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12 December 2020

Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells

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12 December 2020

Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells

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12 December 2020

Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors.

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12 December 2020

Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line

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12 December 2020

Contributions of saturable active secretion, passive transcellular, and paracellular diffusion to the overall transport of furosemide across adenocarcinoma (Caco-2) cells

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12 December 2020

Flux measurements across Caco-2 monolayers may predict transport in human large intestinal tissue

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12 December 2020

Comparison of HT29-18-C1 and Caco-2 cell lines as models for studying intestinal paracellular drug absorption.

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12 December 2020

Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach

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12 December 2020

A conditionally immortalized epithelial cell line for studies of intestinal drug transport.

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12 December 2020

Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins

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12 December 2020

Conditionally immortalized intestinal epithelial cells: novel approach for study of differentiated enterocytes

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12 December 2020

Absorption enhancement in intestinal epithelial Caco-2 monolayers by sodium caprate: assessment of molecular weight dependence and demonstration of transport routes

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12 December 2020

Estimation of the relative contribution of the transcellular and paracellular pathway to the transport of passively absorbed drugs in the Caco-2 cell culture model

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12 December 2020

Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond

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12 December 2020

Evaluation of dynamic polar molecular surface area as predictor of drug absorption: comparison with other computational and experimental predictors

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12 December 2020

Experimental and computational screening models for prediction of aqueous drug solubility

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12 December 2020

Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates

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12 December 2020

The influence of net water absorption on the permeability of antipyrine and levodopa in the human jejunum

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12 December 2020

Rational use of in vitro P-glycoprotein assays in drug discovery

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12 December 2020

A new technique for segmental jejunal perfusion in man

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12 December 2020

Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides

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12 December 2020

Paracellular diffusion in Caco-2 cell monolayers: effect of perturbation on the transport of hydrophilic compounds that vary in charge and size

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12 December 2020

Modulation of the tight junctions of the Caco-2 cell monolayers by H2-antagonists

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12 December 2020

Selective paracellular permeability in two models of intestinal absorption: cultured monolayers of human intestinal epithelial cells and rat intestinal segments

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12 December 2020

Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway

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12 December 2020

A new diffusion chamber system for the determination of drug permeability coefficients across the human intestinal epithelium that are independent of the unstirred water layer

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12 December 2020

Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells

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12 December 2020

Human jejunal effective permeability and its correlation with preclinical drug absorption models

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12 December 2020

Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers.

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12 December 2020

Analysis of drug permeation across Caco-2 monolayer: implication for predicting in vivo drug absorption.

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12 December 2020

Estimation of oral bioavailability of a long half-life drug in healthy subjects

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12 December 2020

Occludin: a novel integral membrane protein localizing at tight junctions

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12 December 2020

Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut

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12 December 2020

Absorption profiles for polyethylene glycols after regional jejunal perfusion and oral load in healthy humans

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12 December 2020

Permeability of the rat small intestinal epithelium along the villus-crypt axis: effects of glucose transport

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12 December 2020

Caco-2 monolayers in experimental and theoretical predictions of drug transport

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12 December 2020

Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers

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12 December 2020

An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: characterization of transport routes.

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12 December 2020

Polar molecular surface properties predict the intestinal absorption of drugs in humans.

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12 December 2020

Experimental and computational screening models for the prediction of intestinal drug absorption

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12 December 2020

Identifiers

DOI

10.1023/A:1022699920043

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22 September 2017

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