(Q36666798)

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Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling

scientific article published on 8 January 2013

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scholarly article

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Europe PubMed Central

15 August 2017

Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling (English)

1 reference

Europe PubMed Central

15 August 2017

object named as

Tessa L Holyoake

4

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Randall T. Moon

object named as

Randall T Moon

5

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author name string

Bin Zhang

1

1 reference

Europe PubMed Central

15 August 2017

Min Li

2

1 reference

Europe PubMed Central

15 August 2017

Tinisha McDonald

3

1 reference

Europe PubMed Central

15 August 2017

Dario Campana

6

1 reference

Europe PubMed Central

15 August 2017

Leonard Shultz

7

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Europe PubMed Central

15 August 2017

Ravi Bhatia

8

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Europe PubMed Central

15 August 2017

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publication date

8 January 2013

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Europe PubMed Central

15 August 2017

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Europe PubMed Central

15 August 2017

121

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Europe PubMed Central

15 August 2017

10

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Europe PubMed Central

15 August 2017

1824-1838

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Europe PubMed Central

15 August 2017

describes a project that uses

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Europe PubMed Central

22 June 2022

https://europepmc.org/article/PMC/3591802

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inferred from PubMed Central ID database lookup

Potentiation of Nilotinib-mediated cell death in the context of the bone marrow microenvironment requires a promiscuous JAK inhibitor in CML.

1 reference

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Blockade of JAK2-mediated extrinsic survival signals restores sensitivity of CML cells to ABL inhibitors.

1 reference

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Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment

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Regulation of cadherin expression in the chicken neural crest by the Wnt/β-catenin signaling pathway

1 reference

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Enrichment of N-Cadherin and Tie2-bearing CD34+/CD38-/CD123+ leukemic stem cells by chemotherapy-resistance

1 reference

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N-cadherin is expressed on human hematopoietic progenitor cells and mediates interaction with human mesenchymal stromal cells

1 reference

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Imatinib and beyond--exploring the full potential of targeted therapy for CML.

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Proximal events in Wnt signal transduction

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The leukemic stem cell niche: current concepts and therapeutic opportunities

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Wnt-related molecules and signaling pathway equilibrium in hematopoiesis

1 reference

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30 September 2017

beta-catenin is involved in N-cadherin-dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells

1 reference

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Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100.

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Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells

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BCR-ABL-transformed GMP as myeloid leukemic stem cells

1 reference

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Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance

1 reference

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CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells

1 reference

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30 September 2017

EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt

1 reference

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Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo

1 reference

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Increased resistance to a farnesyltransferase inhibitor by N-cadherin expression in Bcr/Abl-P190 lymphoblastic leukemia cells

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The stem cell niche in health and leukemic disease

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Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation

1 reference

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Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

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Direct observation of individual endogenous protein complexes in situ by proximity ligation

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Targeting of CD44 eradicates human acute myeloid leukemic stem cells

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Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells

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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

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1 reference

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Links between signal transduction, transcription and adhesion in epithelial bud development

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Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

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Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML.

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Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance

1 reference

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N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells

1 reference

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Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance.

1 reference

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Beta1 integrin mediated adhesion increases Bim protein degradation and contributes to drug resistance in leukaemia cells.

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Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction

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BCR/ABL kinase inhibition by imatinib mesylate enhances MAP kinase activity in chronic myelogenous leukemia CD34+ cells

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20 September 2018

Identifiers

10.1182/BLOOD-2012-02-412890

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Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

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