(Q36666934)

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Janus-faced role of endothelial NO synthase in vascular disease: uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal

scientific article published on December 2006

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scholarly article

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Europe PubMed Central

PubMed publication ID

15 August 2017

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Europe PubMed Central

Janus-faced role of endothelial NO synthase in vascular disease: uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal (English)

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

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vascular disease

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based on heuristic

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author name string

Ulrich Förstermann

1

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Europe PubMed Central

PubMed publication ID

15 August 2017

publication date

1 December 2006

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Europe PubMed Central

PubMed publication ID

15 August 2017

Biological Chemistry

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Europe PubMed Central

PubMed publication ID

15 August 2017

387

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

1521-1533

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

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Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets

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Arginase pathway in human endothelial cells in pathophysiological conditions.

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Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels

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Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction

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Sensitivity of flavin fluorescence dynamics in neuronal nitric oxide synthase to cofactor-induced conformational changes and dimerization

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Antioxidant vitamins and risk of cardiovascular disease. Review of large-scale randomised trials

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Structure of nitric oxide synthase oxygenase dimer with pterin and substrate

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Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity

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Neutrophil superoxide anion--generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy

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Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells

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Protein kinase C inhibitors as novel anticancer drugs

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Electrochemistry of pterin cofactors and inhibitors of nitric oxide synthase

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Novel NAD(P)H oxidases in the cardiovascular system

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Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase

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The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine

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Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease

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Role of bound zinc in dimer stabilization but not enzyme activity of neuronal nitric-oxide synthase.

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The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals

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Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals

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Advanced glycosylation endproducts block the antiproliferative effect of nitric oxide. Role in the vascular and renal complications of diabetes mellitus

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Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats

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Nitric oxide availability in diabetes mellitus.

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Long-term effect of combined vitamins E and C on coronary and peripheral endothelial function

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Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin.

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Effect of AT1 receptor blockade on endothelial function in essential hypertension

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Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide

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Nitric oxide: an endogenous modulator of leukocyte adhesion

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The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals

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Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase.

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Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans

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Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase

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Midostaurin upregulates eNOS gene expression and preserves eNOS function in the microcirculation of the mouse

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Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats.

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Beyond lipid lowering: the role of statins in vascular protection

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Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase

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Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production

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Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial

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The C331A mutant of neuronal nitric-oxide synthase is defective in arginine binding.

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Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry

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Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function

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Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction

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Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis

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Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling

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Upregulation of vascular NAD(P)H oxidase subunit gp91phox and impairment of the nitric oxide signal transduction pathway in hypertension

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Potentiometric analysis of the flavin cofactors of neuronal nitric oxide synthase

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Hypercholesterolemia increases endothelial superoxide anion production

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L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits

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Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy.

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Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta

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Role of neutral amino acid transport and protein breakdown for substrate supply of nitric oxide synthase in human endothelial cells.

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Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

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1 reference

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Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials

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Superoxide and peroxynitrite in atherosclerosis

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Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits

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Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide synthase-serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution.

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Folic acid improves arterial endothelial function in adults with hyperhomocystinemia.

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The effect of insufficiency of tetrahydrobiopterin on endothelial function and vasoactivity

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Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells

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Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles

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Enhanced expression of angiotensin-converting enzyme is associated with progression of coronary atherosclerosis in humans

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Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation

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Identifiers

10.1515/BC.2006.190

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

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