(Q36684906)

15 August 2017

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title

Notch signalling during peripheral T-cell activation and differentiation (English)

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15 August 2017

Barbara A Osborne

1

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PubMed ID

17170755

15 August 2017

Lisa M Minter

series ordinal

2

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PubMed ID

17170755

15 August 2017

language of work or name

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15 December 2006

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Nature Reviews Immunology

15 August 2017

12

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based on heuristic

inferred from page(s)

published in

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15 August 2017

7

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15 August 2017

1

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15 August 2017

64-75

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15 August 2017

The Theory of the Gene

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An overview of the Notch signalling pathway

31 March 2020

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Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

31 March 2020

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Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.

31 March 2020

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Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma

31 March 2020

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Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice

31 March 2020

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Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

31 March 2020

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A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif

31 March 2020

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Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex

31 March 2020

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The notch pathway intermediate HES-1 silences CD4 gene expression

31 March 2020

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A role for pref-1 and HES-1 in thymocyte development.

31 March 2020

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Overexpression of HES-1 is not sufficient to impose T-cell differentiation on human hematopoietic stem cells.

31 March 2020

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Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

31 March 2020

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Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family

31 March 2020

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The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway

31 March 2020

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Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development

31 March 2020

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Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells

31 March 2020

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Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.

31 March 2020

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Characterization of the transcriptional expression of Notch-1 signaling pathway members, Deltex and HES-1, in developing mouse thymocytes.

31 March 2020

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Notch1 augments NF-kappaB activity by facilitating its nuclear retention

31 March 2020

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TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells

31 March 2020

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The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells.

31 March 2020

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Deficient T cell fate specification in mice with an induced inactivation of Notch1.

31 March 2020

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Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus.

31 March 2020

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Requirement for Notch1 signals at sequential early stages of intrathymic T cell development

31 March 2020

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Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision

31 March 2020

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Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

31 March 2020

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Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations

31 March 2020

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Notch activity influences the alphabeta versus gammadelta T cell lineage decision

31 March 2020

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Sustained Notch1 signaling instructs the earliest human intrathymic precursors to adopt a gammadelta T-cell fate in fetal thymus organ culture.

31 March 2020

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Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling.

31 March 2020

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Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.

31 March 2020

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Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation

31 March 2020

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An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

31 March 2020

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Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength

31 March 2020

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A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development

31 March 2020

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Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.

31 March 2020

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T cell receptor signaling: beyond complex complexes

31 March 2020

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The lineage decisions of helper T cells

31 March 2020

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Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation

31 March 2020

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Cell cycle controlling the silencing and functioning of mammalian activators.

31 March 2020

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A novel transcription factor, T-bet, directs Th1 lineage commitment

31 March 2020

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The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

31 March 2020

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Notch signalling: a simple pathway becomes complex

31 March 2020

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Regulation of notch signaling by o-linked fucose.

31 March 2020

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Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding.

31 March 2020

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The Notch1 receptor is cleaved constitutively by a furin-like convertase

31 March 2020

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A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

31 March 2020

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Fringe modulates Notch-ligand interactions.

31 March 2020

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Fringe is a glycosyltransferase that modifies Notch

31 March 2020

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Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.

31 March 2020

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Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1

31 March 2020

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The roles of receptor and ligand endocytosis in regulating Notch signaling

31 March 2020

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kuzbanian-mediated cleavage of Drosophila Notch

31 March 2020

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A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling

31 March 2020

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Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation.

31 March 2020

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Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells.

31 March 2020

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Notch ligands Delta-like1, Delta-like4 and Jagged1 differentially regulate activation of peripheral T helper cells.

31 March 2020

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A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

31 March 2020

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Consequences of Notch-mediated induction of Jagged1.

31 March 2020

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Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice

31 March 2020

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Notch signaling augments T cell responsiveness by enhancing CD25 expression.

31 March 2020

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DNER acts as a neuron-specific Notch ligand during Bergmann glial development

31 March 2020

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F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation

31 March 2020

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NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes.

31 March 2020

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The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway

31 March 2020

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Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation

31 March 2020

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Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats

31 March 2020

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

31 March 2020

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Signalling downstream of activated mammalian Notch

31 March 2020

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Sharp, an inducible cofactor that integrates nuclear receptor repression and activation

31 March 2020

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SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway

31 March 2020

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CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex

31 March 2020

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RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes

31 March 2020

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A role for SKIP in EBNA2 activation of CBF1-repressed promoters

31 March 2020

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Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors

31 March 2020

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Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line

31 March 2020

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p300 acts as a transcriptional coactivator for mammalian Notch-1

31 March 2020

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p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro

31 March 2020

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Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5

31 March 2020

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Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

31 March 2020

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Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex

31 March 2020

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Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

31 March 2020

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Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling.

31 March 2020

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Normal immune system development in mice lacking the Deltex-1 RING finger domain

31 March 2020

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T cells develop normally in the absence of both Deltex1 and Deltex2

31 March 2020

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NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa

31 March 2020

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Basal Expression of IκBα Is Controlled by the Mammalian Transcriptional Repressor RBP-J (CBF1) and Its Activator Notch1

31 March 2020

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Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors

31 March 2020

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Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells

31 March 2020

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Binding of C/EBP and RBP (CBF1) to overlapping sites regulates interleukin-6 gene expression

31 March 2020

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CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1.

31 March 2020

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Functional interactions between an atypical NF-kappaB site from the rat CYP2B1 promoter and the transcriptional repressor RBP-Jkappa/CBF1.

31 March 2020

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T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells

31 March 2020

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Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain

31 March 2020

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The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T Cells

31 March 2020

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Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals

31 March 2020

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Glycogen synthase kinase-3beta modulates notch signaling and stability

31 March 2020

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Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways

31 March 2020

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Notch1 co-localizes with CD4 on activated T cells and Notch signaling is required for IL-10 production.

31 March 2020

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The Notch regulator Numb links the Notch and TCR signaling pathways

31 March 2020

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PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia

31 March 2020

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Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

31 March 2020

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Gamma-secretase: proteasome of the membrane?

31 March 2020

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Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.

31 March 2020

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Notch signaling is an important regulator of type 2 immunity.

31 March 2020

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Notch1 expression on T cells is not required for CD4+ T helper differentiation

31 March 2020

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Linked suppression in peripheral T cell tolerance to the house dust mite derived allergen Der p 1

31 March 2020

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Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.

31 March 2020

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Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells

31 March 2020

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Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes

31 March 2020

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Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells

31 March 2020

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Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism.

31 March 2020

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Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes

31 March 2020

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Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation

31 March 2020

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A novel NF-kappa B-regulated site within the human I gamma 1 promoter requires p300 for optimal transcriptional activity

31 March 2020

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The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis

31 March 2020

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Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.

31 March 2020

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NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions.

31 March 2020

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Missing pieces in the NF-kappaB puzzle

31 March 2020

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31 March 2020

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NF-kappaB regulation in the immune system

31 March 2020

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Deciphering the pathway from the TCR to NF-kappaB

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1998

1 reference

15 August 2017

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PubMed ID

17170755