(Q36702370)

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From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part II-Sensitivity to Physiological and Physicochemical Properties

scientific article published on 10 October 2012

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Europe PubMed Central

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6 March 2020

From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part II-Sensitivity to Physiological and Physicochemical Properties (English)

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6 March 2020

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Sandra den Hoedt

3

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6 March 2020

Catherijne Knibbe

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6 March 2020

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D Tibboel

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6 March 2020

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E H J Krekels

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6 March 2020

T N Johnson

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6 March 2020

A Rostami-Hodjegan

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6 March 2020

M Danhof

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6 March 2020

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10 October 2012

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6 March 2020

CPT: pharmacometrics & systems pharmacology

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6 March 2020

1

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6 March 2020

e10

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6 March 2020

From pediatric covariate model to semiphysiological function for maturation: part I-extrapolation of a covariate model from morphine to Zidovudine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

30 September 2017

Ontogeny of hepatic glucuronidation; methods and results

1 reference

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30 September 2017

Morphine glucuronidation in preterm neonates, infants and children younger than 3 years

1 reference

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30 September 2017

Oral diacetylmorphine (heroin) yields greater morphine bioavailability than oral morphine: bioavailability related to dosage and prior opioid exposure

1 reference

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30 September 2017

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

1 reference

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30 September 2017

Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children

1 reference

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30 September 2017

Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation

1 reference

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30 September 2017

Differential in vitro inhibition of M3G and M6G formation from morphine by (R)- and (S)-methadone and structurally related opioids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

30 September 2017

In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

30 September 2017

3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

30 September 2017

The pharmacokinetics of morphine and morphine glucuronide metabolites after subcutaneous bolus injection and subcutaneous infusion of morphine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

30 September 2017

Human UGT2B7 catalyzes morphine glucuronidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

30 September 2017

Morphine sulphation in children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

30 September 2017

Microelectrometric titration measurement of the pKa's and partition and drug distribution coefficients of narcotics and narcotic antagonists and their pH and temperature dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

30 September 2017

Morphine binding to human plasma proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

30 September 2017

Temperature and pH sensitivity of the partition coefficient as related to the blood-brain barrier to drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

30 September 2017

Clinical pharmacokinetics of zidovudine. An update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

30 September 2017

Intravascular distribution of zidovudine: role of plasma proteins and whole blood components.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

28 June 2018

Population pharmacokinetics of zidovudine. The Veterans Administration Cooperative Studies Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

28 June 2018

Uptake of morphine and nalorphine by isolated rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

28 June 2018

Kinetics of intravenous and intramuscular morphine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

28 June 2018

Bovine serum albumin decreases Km values of human UDP-glucuronosyltransferases 1A9 and 2B7 and increases Vmax values of UGT1A9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

5 September 2018

Predictive Performance of a Recently Developed Population Pharmacokinetic Model for Morphine and its Metabolites in New Datasets of (Preterm) Neonates, Infants and Children.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

5 September 2018

Transport is not rate-limiting in morphine glucuronidation in the single-pass perfused rat liver preparation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

5 September 2018

Changes in liver volume from birth to adulthood: a meta-analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

5 September 2018

Altered AZT (3'-azido-3'-deoxythymidine) glucuronidation kinetics in liver microsomes as an explanation for underprediction of in vivo clearance: comparison to hepatocytes and effect of incubation environment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

5 September 2018

Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

5 September 2018

Morphine blood-brain barrier transport is influenced by probenecid co-administration

1 reference

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5 September 2018

Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro

1 reference

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5 September 2018

A preliminary study on the distribution of morphine and its glucuronides in the subcompartments of blood.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

5 September 2018

British 1990 growth reference centiles for weight, height, body mass index and head circumference fitted by maximum penalized likelihood

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

5 September 2018

Uptake, 3-, and 6-glucuronidation of morphine in isolated cells from stomach, intestine, colon, and liver of the guinea pig.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603432

5 September 2018

The Maturation of Morphine Clearance and Metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23887362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sex differences in morphine analgesia: an experimental study in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23887362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic extraction of morphine is impaired in cirrhosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23887362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23887362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding to human serum albumin of zidovudine (AZT) and novel AZT derivatives. Experimental and theoretical analyses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23887362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of inhibitory fatty acids is responsible for the enhancement of UDP-glucuronosyltransferase 2B7 activity by albumin: implications for in vitro-in vivo extrapolation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23887362

12 December 2020

based on heuristic

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10.1038/PSP.2012.12

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Europe PubMed Central

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6 March 2020

PMC publication ID

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Europe PubMed Central

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6 March 2020

PubMed publication ID

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Europe PubMed Central

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6 March 2020

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