(Q36709527)

15 August 2017

1 reference

title

NF-kappa B as a therapeutic target in neurodegenerative diseases (English)

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15 August 2017

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1 reference

1

Simonetta Camandola

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15 August 2017

2

Mark P Mattson

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PubMed ID

17227229

15 August 2017

language of work or name

English

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publication date

1 February 2007

1 reference

Expert Opinion on Therapeutic Targets

15 August 2017

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15 August 2017

11

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15 August 2017

2

1 reference

15 August 2017

123-132

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NF-kappaB and IKK as therapeutic targets in cancer

15 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Inhibition of nuclear factor kappa B (NF-B): an emerging theme in anti-inflammatory therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

NF-kappaB at the crossroads of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Modulation of NF-kappaB activity by exchange of dimers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Neurotrophins regulate the function of cultured microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Regulation of NF-kappa B activity in rat dorsal root ganglia and PC12 cells by tumour necrosis factor and nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Neuronal kappa B-binding factors consist of Sp1-related proteins. Functional implications for autoregulation of N-methyl-D-aspartate receptor-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Brain synapses contain inducible forms of the transcription factor NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Gene expression of the transcription factor NF-kappa B in hippocampus: regulation by synaptic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

NF-kappa B functions in synaptic signaling and behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Nuclear factor-kappaB mediates the cell survival-promoting action of activity-dependent neurotrophic factor peptide-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

A mu-receptor opioid agonist induces AP-1 and NF-kappa B transcription factor activity in primary cultures of rat cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Induction of neuroprotective kappa B-dependent transcription by secreted forms of the Alzheimer's beta-amyloid precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Retrograde transport of transcription factor NF-kappa B in living neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

NF-κB and IκBα Are Found in the Mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Axonal mitochondrial transport and potential are correlated

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

A requirement of nuclear factor-kappaB activation in fear-potentiated startle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

NF-kappaB transcription factor is required for inhibitory avoidance long-term memory in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Activation of the transcription factor NF-kappaB by retrieval is required for long-term memory reconsolidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Lack of NF-kappaB p50 exacerbates degeneration of hippocampal neurons after chemical exposure and impairs learning

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-rel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

NF-kappaB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

In utero gene therapy: the case for.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Nuclear factor-kappaB contributes to infarction after permanent focal ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

NF-kappaB protects neurons from ischemic injury after middle cerebral artery occlusion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Roles for NF-kappaB in nerve cell survival, plasticity, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

NF-kappaB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid beta-peptide toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Enhancement of immunoreactivity for NF-kappa B in the hippocampal formation and cerebral cortex of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

NF-kB immunoreactivity is observed in association with beta A4 diffuse plaques in patients with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor kappa B in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

The lipid peroxidation product 4-hydroxy-2,3-nonenal increases AP-1-binding activity through caspase activation in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Identification and characterization of a kappa B/Rel binding site in the regulatory region of the amyloid precursor protein gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

NF-kappaB pathway: a target for preventing beta-amyloid (Abeta)-induced neuronal damage and Abeta42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Activation of NF-kappaB is involved in 6-hydroxydopamine-but not MPP+ -induced dopaminergic neuronal cell death: its potential role as a survival determinant

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Neuroprotective role for the p50 subunit of NF-kappaB in an experimental model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

IKK mediates ischemia-induced neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

The NF-kappaB inhibitor diethyldithiocarbamate (DDTC) increases brain cell death in a transient middle cerebral artery occlusion model of ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

The IKK NF-kappa B system: a treasure trove for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Meta-analysis of nonsteroidal antiinflammatory drug use and risk of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Thalidomide reduces MPTP-induced decrease in striatal dopamine levels in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Dietary intake of antioxidants and risk of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Influence of the severity of cognitive impairment on the effect of the Gnkgo biloba extract EGb 761 in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Activation of nuclear factor-kappaB via endogenous tumor necrosis factor alpha regulates survival of axotomized adult sensory neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Activation of AP-1 and Nuclear Factor-κB Transcription Factors Is Involved in Hydrogen Peroxide-Induced Apoptotic Cell Death of Olligodendrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

Activation of nuclear factor kB in brains from children with HIV-I encephalitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.123

10.1517/14728222.11.2.123

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

17227229