(Q36715471)

English

The straw that stirs the drink: insight into the pathogenesis of inflammatory bowel disease revealed through the study of microflora-induced inflammation in genetically modified mice

scientific article published on April 2007

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

1 reference

Europe PubMed Central

The straw that stirs the drink: insight into the pathogenesis of inflammatory bowel disease revealed through the study of microflora-induced inflammation in genetically modified mice (English)

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

inflammatory bowel diseases

0 references

author name string

Bruce H Horwitz

1

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 April 2007

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

Inflammatory Bowel Diseases

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

13

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

490-500

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

Interleukin-10-deficient mice develop chronic enterocolitis

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria.

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Control of regulatory T cell development by the transcription factor Foxp3

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Th17: an effector CD4 T cell lineage with regulatory T cell ties

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Transforming growth factor-beta induces development of the T(H)17 lineage

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Interleukin-23 drives innate and T cell-mediated intestinal inflammation

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Interleukin-12 and the regulation of innate resistance and adaptive immunity

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2(-/-) mice upon transfer of CD4(+)CD45RB(hi) T cells

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Shaping gene expression in activated and resting primary macrophages by IL-10.

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells.

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Interleukin-10 inhibits interleukin-12 p40 gene transcription by targeting a late event in the activation pathway

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Inflammatory Bowel Disease

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-kappa B decoy oligonucleotides

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B.

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Genetic and environmental context determines the course of colitis developing in IL-10-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

TIR, CARD and PYRIN: three domains for an antimicrobial triad

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Role of Nod2 in the Response of Macrophages to Toll-Like Receptor Agonists

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

NOD2 and Crohn's disease: loss or gain of function?

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's Disease IL-10 Cooperative Study Group

1 reference

https://api.crossref.org/works/10.1002%2FIBD.20098

21 January 2018

Identifiers

10.1002/IBD.20098

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

15 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q36715471&oldid=1647242106"