(Q36724953)

15 August 2017

Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein (English)

1 reference

15 August 2017

1 reference

Liskin Swint-Kruse

6

0 references

Andrew E Whitten

object named as

Andrew E Whitten

3

0 references

Jill Trewhella

object named as

Jill Trewhella

7

0 references

David Langley

4

object named as

David B Langley

0 references

author name string

Marc Taraban

1

1 reference

15 August 2017

Hongli Zhan

2

1 reference

15 August 2017

Kathleen S Matthews

5

1 reference

15 August 2017

language of work or name

English

0 references

publication date

28 November 2007

1 reference

Journal of Molecular Biology

15 August 2017

1 reference

15 August 2017

376

1 reference

15 August 2017

466-481

1 reference

15 August 2017

2

1 reference

Structural analysis of lac repressor bound to allosteric effectors

15 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Probing transcription factor dynamics at the single-molecule level in a living cell

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Functional consequences of exchanging domains between LacI and PurR are mediated by the intervening linker sequence

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Modeling the Lac repressor-operator assembly: the influence of DNA looping on Lac repressor conformation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Extrinsic interactions dominate helical propensity in coupled binding and folding of the lactose repressor protein hinge helix

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

An amino-terminal fragment of lac repressor binds specifically to lac operator

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Isolation of the lac repressor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Global rigid body modeling of macromolecular complexes against small-angle scattering data

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Structural dynamics of the lac repressor-DNA complex revealed by a multiscale simulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Calculation of standard atomic volumes for RNA and comparison with proteins: RNA is packed more tightly

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Coot: model-building tools for molecular graphics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Fluorescence resonance energy transfer over approximately 130 basepairs in hyperstable lac repressor-DNA loops

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Plasticity in protein-DNA recognition: lac repressor interacts with its natural operator 01 through alternative conformations of its DNA-binding domain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Fine-tuning function: correlation of hinge domain interactions with functional distinctions between LacI and PurR

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Structure of a variant of lac repressor with increased thermostability and decreased affinity for operator

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Crystallographic analysis of Lac repressor bound to natural operator O1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Strong DNA binding by covalently linked dimeric Lac headpiece: evidence for the crucial role of the hinge helices

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Operator DNA sequence variation enhances high affinity binding by hinge helix mutants of lactose repressor protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

A closer view of the conformation of the Lac repressor bound to operator

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

The solution structure of Lac repressor headpiece 62 complexed to a symmetrical lac operator

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Comparison of simulated and experimentally determined dynamics for a variant of the Lacl DNA-binding domain, Nlac-P.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Refined structure of lac repressor headpiece (1-56) determined by relaxation matrix calculations from 2D and 3D NOE data: change of tertiary structure upon binding to the lac operator

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Crystal structure of the lactose operon repressor and its complexes with DNA and inducer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Genetic analysis of the leucine heptad repeats of Lac repressor: evidence for a 4-helical bundle.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Coupling of local folding to site-specific binding of proteins to DNA

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Structure of the complex of lac repressor headpiece and an 11 base-pair half-operator determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Crystal structure of lac repressor core tetramer and its implications for DNA looping

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Mechanism of corepressor-mediated specific DNA binding by the purine repressor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

The Location of the Repressor Binding Sites in the lac Operon

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Lac repressor. Specific proteolytic destruction of the NH 2 -terminal region and loss of the deoxyribonucleic acid-binding activity.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Lac repressor binding to poly (d(A-T)). Conformational changes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

lac repressor--operator interaction. II. Effect of galactosides and other ligands

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

lac repressor forms loops with linear DNA carrying two suitably spaced lac operators

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Role of the hydrophobic effect in stability of site-specific protein-DNA complexes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

The three operators of the lac operon cooperate in repression

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Deletion of lactose repressor carboxyl-terminal domain affects tetramer formation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

A comparison of lac repressor binding to operator and to nonoperator DNA

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Interaction of effecting ligands with lac repressor and repressor-operator complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Formation of the hinge helix in the lac repressor is induced upon binding to the lac operator.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

lac Repressor-operator interaction. VI. The natural inducer of the lac operon.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Comparison of the crystal and solution structures of calmodulin and troponin C

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Upstream operators enhance repression of the lac promoter

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Synthetic lac operator mediates repression through lac repressor when introduced upstream and downstream from lac promoter

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Stability of a Lac repressor mediated "looped complex".

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Dimer-to-tetramer assembly of Lac repressor involves a leucine heptad repeat.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

A family of bacterial regulators homologous to Gal and Lac repressors.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

“Second” and “third operator” of the lac operon: An investigation of their role in the regulatory mechanism

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Integrated insights from simulation, experiment, and mutational analysis yield new details of LacI function

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Coarse-grained model of entropic allostery.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Using networks to identify fine structural differences between functionally distinct protein states

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Structure and flexibility adaptation in nonspecific and specific protein-DNA complexes.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

"Antiparallel" DNA loop in gal repressosome visualized by atomic force microscopy

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Generation of an AraC-araBAD promoter-regulated T7 expression system

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Wild-type operator binding and altered cooperativity for inducer binding of lac repressor dimer mutant R3.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Subunit dissociation affects DNA binding in a dimeric lac repressor produced by C-terminal deletion.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2430094

Allosteric regulation of inducer and operator binding to the lactose repressor

5 September 2018

1 reference

12 December 2020

Small-angle X-ray studies of the quaternary structure of the lac repressor from Escherichia coli

1 reference

12 December 2020

Specific destruction of the second lac operator decreases repression of the lac operon in Escherichia coli fivefold

1 reference

12 December 2020

Nonspecific binding of lac repressor to DNA. II. A small-angle neutron-scattering study

1 reference

12 December 2020

Escherichia coli lac repressor is elongated with its operator DNA binding domains located at both ends

1 reference

12 December 2020

Neutron-scattering studies of lac repressor: a low-resolution model

1 reference

12 December 2020

Conformation of Lac repressor tetramer in solution, bound and unbound to operator DNA

1 reference

12 December 2020

Lac repressor-Lac operator complexes. Solution X-ray scattering and electrophoretic studies

1 reference

12 December 2020

Binding of lac repressor induces different conformational changes on operator and non-operator DNAs

1 reference

12 December 2020

Neutron scattering studies of lac repressor

1 reference

12 December 2020

Quantitative analysis and interpretation of allosteric behavior

1 reference

12 December 2020

Predicted structure of the sugar-binding site of the lac repressor

1 reference

12 December 2020

The general affinity of lac repressor for E. coli DNA: Implications for gene regulation in procaryotes and eucaryotes

1 reference

12 December 2020

Molecular conformation of egg-white lysozyme and bovine α-lactalbumin in solution

1 reference

12 December 2020

10.1016/J.JMB.2007.11.067

Identifiers

DOI

1 reference

15 August 2017

1 reference

15 August 2017

1 reference