(Q36728827)

15 August 2017

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title

Clinical significance of the p53 pathway and associated gene therapy in non-small cell lung cancers (English)

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15 August 2017

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Cheng-long Huang

1

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15 August 2017

Hiroyasu Yokomise

series ordinal

2

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15 August 2017

Akira Miyatake

series ordinal

3

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15 August 2017

language of work or name

English

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publication date

1 February 2007

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15 August 2017

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15 August 2017

volume

3

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15 August 2017

issue

1

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15 August 2017

page(s)

83-93

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Cancer prevalence in European registry areas

15 August 2017

cites work

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Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies

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Surfing the p53 network

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Prognostic molecular markers in non-small cell lung cancer

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Regulation of p53 stability by Mdm2

21 January 2018

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21 January 2018

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Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

21 January 2018

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The role of the tumour suppressor p33 ING1b in human neoplasia

21 January 2018

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Function of the ING family of PHD proteins in cancer

21 January 2018

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DNA microarrays identification of primary and secondary target genes regulated by p53.

21 January 2018

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Global genechip profiling to identify genes responsive to p53-induced growth arrest and apoptosis in human lung carcinoma cells

21 January 2018

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The transcriptional targets of p53 in apoptosis control

21 January 2018

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Physical and functional interactions between members of the tumour suppressor p53 and the Sp families of transcription factors: importance for the regulation of genes involved in cell-cycle arrest and apoptosis

21 January 2018

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p53 apoptotic pathway molecules are frequently and simultaneously altered in nonsmall cell lung carcinoma

21 January 2018

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Gene replacement therapy for non-small cell lung cancer: a review

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

21 January 2018

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

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Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

21 January 2018

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Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway

21 January 2018

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PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

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Wild-type p53 overexpression and its correlation with MDM2 and p14ARF alterations: an alternative pathway to non-small-cell lung cancer.

21 January 2018

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Activation of p53 DNA binding activity by point mutation

21 January 2018

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A novel p53 mutant retained functional activity in lung carcinomas.

21 January 2018

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Mutations in exon 7 and 8 of p53 as poor prognostic factors in patients with non-small cell lung cancer

21 January 2018

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Overexpression of bax associated with mutations in the loop-sheet-helix motif of p53

21 January 2018

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Comparison of p53 mutations between adenocarcinoma and squamous cell carcinoma of the lung: unique spectra involving G to A transitions and G to T transversions in both histologic types.

21 January 2018

1 reference

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P21 gene expression as an indicator for the activity of adenovirus-p53 gene therapy in non-small cell lung cancer patients

21 January 2018

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Adenovirus-mediated wild-type p53 gene expression radiosensitizes non-small cell lung cancer cells but not normal lung fibroblasts

21 January 2018

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Induction of p53-regulated genes in lung cancer cells: implications of the mechanism for adenoviral p53-mediated apoptosis.

21 January 2018

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Multicenter phase I study of repeated intratumoral delivery of adenoviral p53 in patients with advanced non-small-cell lung cancer

21 January 2018

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Late resistance to adenoviral p53-mediated apoptosis caused by decreased expression of Coxsackie-adenovirus receptors in human lung cancer cells

21 January 2018

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Non-small lung cancer cells are prime targets for p53 gene transfer mediated by a recombinant adeno-associated virus type-2 vector

21 January 2018

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Identification of p53-46F as a super p53 with an enhanced ability to induce p53-dependent apoptosis.

21 January 2018

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A functional p53-responsive intronic promoter is contained within the human mdm2 gene

21 January 2018

1 reference

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MDM2 gene amplification and expression in non-small-cell lung cancer: immunohistochemical expression of its protein is a favourable prognostic marker in patients without p53 protein accumulation

21 January 2018

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Tumor surveillance via the ARF-p53 pathway.

21 January 2018

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p16 protein expression is associated with a poor prognosis in squamous cell carcinoma of the lung

21 January 2018

1 reference

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Aberrant p16 promoter methylation in smokers and former smokers with nonsmall cell lung cancer

21 January 2018

1 reference

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The exogenous wild-type p14ARF gene induces growth arrest and promotes radiosensitivity in human lung cancer cell lines

21 January 2018

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Adenovirus-mediated p14ARF gene transfer cooperates with Ad5CMV-p53 to induce apoptosis in human cancer cells

21 January 2018

1 reference

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Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP

21 January 2018

1 reference

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Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)

21 January 2018

1 reference

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Different HATS of the ING1 gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control

21 January 2018

1 reference

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Human ING1 proteins differentially regulate histone acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Reduced expression of p33(ING1) and the relationship with p53 expression in human gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Downregulation of nuclear expression of the p33(ING1b) inhibitor of growth protein in invasive carcinoma of the breast

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Comparative assessment expression of the inhibitor of growth 1 gene (ING1) in normal and neoplastic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

The tumor suppressor p33ING1b enhances taxol-induced apoptosis by p53-dependent pathway in human osteosarcoma U2OS cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Inhibitory effect of tumor suppressor p33(ING1b) and its synergy with p53 gene in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Molecular epidemiological study of non-small-cell lung cancer from an environmentally polluted region of Poland

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

p21waf1/cip1mda-6 expression in non-small-cell lung cancer: relationship to survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

p53 expression overcomes p21WAF1/CIP1-mediated G1 arrest and induces apoptosis in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Expression of apoptosis regulatory proteins of the Bcl-2 family and p53 in primary resected non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Expression of p53 protein and the apoptotic regulatory molecules Bcl-2, Bcl-XL, and Bax in locally advanced squamous cell carcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

The relationship between cisplatin-induced apoptosis and p53, bcl-2 and bax expression in human lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Therapeutic efficacy of PUMA for malignant glioma cells regardless of p53 status.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Integral role of Noxa in p53-mediated apoptotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

BOK and NOXA are essential mediators of p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Noxa in colorectal cancer: a study on DNA, mRNA and protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

A novel anti-apoptosis gene: Re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Mutations of the p53 gene and loss of heterozygosity at chromosome 17p13.1 are associated with increased survivin expression in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Small interfering RNA targeting survivin sensitizes lung cancer cell with mutant p53 to adriamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Survivin as a therapeutic target for radiation sensitization in lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Tailor-made chemotherapy for non-small cell lung cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Proteasome inhibition with PS-341 (bortezomib) in lung cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.1.83

21 January 2018

Identifiers

DOI

10.2217/14796694.3.1.83

1 reference

15 August 2017

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