(Q36729887)

15 August 2017

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title

Living with heterogeneities in bioreactors: understanding the effects of environmental gradients on cells (English)

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15 August 2017

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environmental gradient

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Alvaro R Lara

1

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Laura A. Palomares

object named as

Laura A Palomares

4

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Octavio T Ramírez

object named as

Octavio T Ramírez

3

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author name string

Enrique Galindo

2

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15 August 2017

Octavio T Ramírez

3

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15 August 2017

language of work or name

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1 November 2006

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15 August 2017

published in

Molecular Biotechnology

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15 August 2017

volume

34

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15 August 2017

issue

3

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15 August 2017

page(s)

355-381

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The effect of oscillating dissolved oxygen concentrations on the metabolism of a Spodoptera frugiperda IPLB-Sf21-AE clonal isolate

15 August 2017

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Design of a Tubular Loop Bioreactor for Scale‐up and Scale‐down of Fermentation Processes

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Mixing and oxygen transfer in conventional stirred fermentors

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Regulation of sugar and ethanol metabolism in Saccharomyces cerevisiae

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12 December 2020

Stable hybridoma cultivation in a pilot-scale acoustic perfusion system: long-term process performance and effect of recirculation rate

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12 December 2020

Further studies related to the scale-up of high cell density Escherichia coli fed-batch fermentations: the additional effect of a changing microenvironment when using aqueous ammonia to control pH.

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12 December 2020

Hydrodynamic damage to animal cells.

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12 December 2020

Cultivation of hybridoma cells in an inclined bioreactor

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12 December 2020

Effect of shear stress on intrinsic CHO culture state and glycosylation of recombinant tissue-type plasminogen activator protein.

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12 December 2020

Culture pH affects expression rates and glycosylation of recombinant mouse placental lactogen proteins by Chinese hamster ovary (CHO) cells

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12 December 2020

Agitator speed and dissolved oxygen effects in xanthan fermentations

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12 December 2020

Fluid shear stress induction of the transcriptional activator c-fos in human and bovine endothelial cells, HeLa, and Chinese hamster ovary cells

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12 December 2020

Protection mechanisms of freely suspended animal cells (CRL 8018) from fluid-mechanical injury. Viscometric and bioreactor studies using serum, pluronic F68 and polyethylene glycol.

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12 December 2020

Evidence of Pluronic F-68 direct interaction with insect cells: impact on shear protection, recombinant protein, and baculovirus production*

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12 December 2020

Influence of scale-up on the quality of recombinant human growth hormone

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12 December 2020

Influence of constant and oscillating dissolved oxygen concentrations on keto acid production by Gluconobacter oxydans subsps. melanogenum

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12 December 2020

Bioreactor cultivation enhances the efficiency of human embryoid body (hEB) formation and differentiation

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12 December 2020

CO(2) in large-scale and high-density CHO cell perfusion culture

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12 December 2020

Experimental simulation of oxygen profiles and their influence on baker's yeast production: II. Two-fermentor system

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12 December 2020

Effect of production method and gene amplification on the glycosylation pattern of a secreted reporter protein in CHO cells.

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12 December 2020

The response of GS-NS0 myeloma cells to single and multiple pH perturbations

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12 December 2020

Protective effect of methylcellulose and other polymers on insect cells subjected to laminar shear stress

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12 December 2020

Interaction between CO2-mass transfer, light availability, and hydrodynamic stress in the growth of phaeodactylum tricornutum in a concentric tube airlift photobioreactor

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12 December 2020

Reactive oxygen species induced by shear stress mediate cell death in Bacillus subtilis.

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12 December 2020

Tobacco smoke as inducer for gas phase-controlled transgene expression in mammalian cells and mice

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12 December 2020

A microbial culture with oxygen-sensitive product distribution as a potential tool for characterizing bioreactor oxygen transport

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12 December 2020

Cell cycle- and growth phase-dependent variations in size distribution, antibody productivity, and oxygen demand in hybridoma cultures

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12 December 2020

Reactor design for large scale suspension animal cell culture

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12 December 2020

Endoplasmic reticulum signaling as a determinant of recombinant protein expression

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12 December 2020

Effects of oxygen on recombinant protein expression

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12 December 2020

Effects of limited aeration and of the ArcAB system on intermediary pyruvate catabolism in Escherichia coli

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12 December 2020

Experimental simulation of dissolved oxygen fluctuations in large fermentors: effect on Streptomyces clavuligerus

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12 December 2020

Culture of Escherichia coli under dissolved oxygen gradients simulated in a two-compartment scale-down system: metabolic response and production of recombinant protein

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12 December 2020

Single-cell variability in growing Saccharomyces cerevisiae cell populations measured with automated flow cytometry

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12 December 2020

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12 December 2020

Temperature-induced synthesis of specific proteins in Escherichia coli: evidence for transcriptional control

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12 December 2020

Effects of Stirring and Hydrogen on Fermentation Products of Clostridium thermocellum.

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12 December 2020

Effect of oscillating dissolved oxygen tension on the production of alginate by Azotobacter vinelandii

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12 December 2020

Heterogeneous conditions in dissolved oxygen affect N-glycosylation but not productivity of a monoclonal antibody in hybridoma cultures.

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12 December 2020

Death mechanisms of animal cells in conditions of intensive agitation.

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12 December 2020

Transcriptional and metabolic response of recombinant Escherichia coli to spatial dissolved oxygen tension gradients simulated in a scale-down system

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12 December 2020

Development of a helical-ribbon impeller bioreactor for high-density plant cell suspension culture

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12 December 2020

Flow parameters associated with hydrodynamic cell injury

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12 December 2020

Monitoring recombinant human interferon-gamma N-glycosylation during perfused fluidized-bed and stirred-tank batch culture of CHO cells

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12 December 2020

Bicarbonate concentration and osmolality are key determinants in the inhibition of CHO cell polysialylation under elevated pCO(2) or pH.

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12 December 2020

Scale-down model to simulate spatial pH variations in large-scale bioreactors

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12 December 2020

Dissolved carbon dioxide accumulation in a large scale and high density production of TGFβ receptor with baculovirus infected Sf-9 cells

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12 December 2020

Physiological response of central metabolism in Escherichia coli to deletion of pyruvate oxidase and introduction of heterologous pyruvate carboxylase

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12 December 2020

Gas-inducible product gene expression in bioreactors

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12 December 2020

Effects of heat shock on the production of human erythropoietin from recombinant CHO cells

1 reference

12 December 2020

Engineering challenges in high density cell culture systems

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12 December 2020

Fundamental Escherichia coli biochemical pathways for biomass and energy production: creation of overall flux states

1 reference

12 December 2020

6-pentyl-alpha-pyrone production by Trichoderma harzianum: the influence of energy dissipation rate and its implications on fungal physiology

1 reference

12 December 2020

Quasi-continuous combined scattered light and fluorescence measurements: a novel measurement technique for shaken microtiter plates.

1 reference

12 December 2020

Influence of substrate oscillations on acetate formation and growth yield in Escherichia coli glucose limited fed-batch cultivations

1 reference

12 December 2020

Glycosylation of CHO-derived recombinant tPA produced under elevated pCO2.

1 reference

12 December 2020

In pursuit of the optimal fed-batch process for monoclonal antibody production

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12 December 2020

A special reactor design for investigations of mixing time effects in a scaled-down industrial L-lysine fed-batch fermentation process

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12 December 2020

Physiological responses to mixing in large scale bioreactors.

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12 December 2020

Inhibition of microbial growth and metabolism by excess turbulence

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12 December 2020

The use of culture redox potential and oxygen uptake rate for assessing glucose and glutamine depletion in hybridoma cultures

1 reference

12 December 2020

Response of guanosine tetraphosphate to glucose fluctuations in fed-batch cultivations of Escherichia coli.

1 reference

12 December 2020

The roles of oxygen and alginate-lyase in determining the molecular weight of alginate produced by Azotobacter vinelandii

1 reference

12 December 2020

Effects of dissolved oxygen shock on the stability of recombinant Escherichia coli containing plasmid pKN401

1 reference

12 December 2020

Experimental simulation of oxygen profiles and their influence on baker's yeast production: I. One-fermentor system

1 reference

12 December 2020

Dissolved oxygen concentration profiles in a production-scale bioreactor

1 reference

12 December 2020

Bioprocess equipment: characterization of energy dissipation rate and its potential to damage cells.

1 reference

12 December 2020

Influence of pH, buffer species, and storage temperature on physicochemical stability of a humanized monoclonal antibody LA298.

1 reference

12 December 2020

Damaging agitation intensities increase DNA synthesis rate and alter cell-cycle phase distributions of CHO cells

1 reference

12 December 2020

The effect of dissolved oxygen tension and the utility of oxygen uptake rate in insect cell culture.

1 reference

12 December 2020

Transient behaviour of baker's yeast during enforced periodical variation of dissolved oxygen concentration

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12 December 2020

Metabolic selectivity and growth of Clostridium thermocellum in continuous culture under elevated hydrostatic pressure

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12 December 2020

Rapid sampling, cell inactivation and evaluation of low extracellular glucose concentrations during fed-batch cultivation.

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12 December 2020

The role of the plasma membrane fluidity on the shear sensitivity of hybridomas grown under hydrodynamic stress

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12 December 2020

Effect of oxygen fluctuations on recombinant Escherichia coli fermentation

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12 December 2020

Homogenisation and oxygen transfer rates in large agitated and sparged animal cell bioreactors: Some implications for growth and production

1 reference

12 December 2020

Scale-down and optimization studies of the gluconic acid fermentation by Gluconobacter oxydans

1 reference

12 December 2020

Control of pH in large-scale, free suspension animal cell bioreactors: alkali addition and pH excursions

1 reference

12 December 2020

Strategies for improved dCO2 removal in large-scale fed-batch cultures

1 reference

12 December 2020

Engineering Escherichia coli to improve culture performance and reduce formation of by-products during recombinant protein production under transient intermittent anaerobic conditions.

1 reference

12 December 2020

Increased agitation intensity increases CD13 receptor surface content and mRNA levels, and alters the metabolism of HL60 cells cultured in stirred tank bioreactors

1 reference

12 December 2020

Influence of controlled glucose oscillations on a fed-batch process of recombinant Escherichia coli

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12 December 2020

Microtechnologies and nanotechnologies for single-cell analysis

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12 December 2020

Effect of cycle time on fungal morphology, broth rheology, and recombinant enzyme productivity during pulsed addition of limiting carbon source.

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12 December 2020

Glucose-limited chemostat culture of Chinese hamster ovary cells producing recombinant human interferon-gamma

1 reference

12 December 2020

Monitoring of genes that respond to process-related stress in large-scale bioprocesses

1 reference

12 December 2020

The influence of dissolved oxygen tension on the synthesis of the antibiotic difficidin by bacillus subtilis

1 reference

12 December 2020

Design and performance of a 24-station high throughput microbioreactor.

1 reference

12 December 2020

Glucose overflow metabolism and mixed-acid fermentation in aerobic large-scale fed-batch processes with Escherichia coli

1 reference

12 December 2020

Shear stress enhances microcin B17 production in a rotating wall bioreactor, but ethanol stress does not.

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12 December 2020

Optimization of the production of virus-like particles in insect cells

1 reference

12 December 2020

Identifiers

DOI

10.1385/MB:34:3:355

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Dimensions Publication ID

15 August 2017

1043318595

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