(Q36731538)

English

Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers.

scientific article published on June 2007

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17545160%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers (English)

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31 December 2019

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Anahit Ghochikyan

4

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31 December 2019

Anatoly Kiyatkin

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31 December 2019

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Grigor Mamikonyan

1

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31 December 2019

Mihaela Necula

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31 December 2019

Mikayel Mkrtichyan

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31 December 2019

Irina Petrushina

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31 December 2019

Nina Movsesyan

6

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31 December 2019

Erene Mina

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31 December 2019

Charles G Glabe

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31 December 2019

David H Cribbs

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31 December 2019

Michael G Agadjanyan

11

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31 December 2019

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1 June 2007

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31 December 2019

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11

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Journal of Biological Chemistry

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31 December 2019

282

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31 December 2019

31

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31 December 2019

22376-22386

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31 December 2019

Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Neurovascular mechanisms of Alzheimer's neurodegeneration

1 reference

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30 September 2017

Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Current progress in beta-amyloid immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer's disease. Pro-CAA position statement.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

A portrait of Alzheimer secretases--new features and familiar faces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Immunization against Alzheimer's beta -amyloid plaques via EFRH phage administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Disaggregation of Alzheimer beta-amyloid by site-directed mAb.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Cellular and molecular biology of Alzheimer's disease and animal models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Alzheimer's disease: a central role for amyloid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Role of the beta-amyloid protein in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Lymphokine control of in vivo immunoglobulin isotype selection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

The molecular pathology of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Alzheimer's disease: the amyloid cascade hypothesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

30 September 2017

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

28 June 2018

Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

28 June 2018

Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

28 June 2018

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Rapid Anionic Micelle-mediated α-Synuclein Fibrillization in Vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Cyanine dye N744 inhibits tau fibrillization by blocking filament extension: implications for the treatment of tauopathic neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Evidence for an intermediate in tau filament formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Apolipoprotein E and antioxidants have different mechanisms of inhibiting Alzheimer's beta-amyloid fibril formation in vitro.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Ligand-dependent inhibition and reversal of tau filament formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700088200

21 January 2018

Importance of IgG2c isotype in the immune response to beta-amyloid in amyloid precursor protein/transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

5 September 2018

Evaluation of the safety and immunogenicity of synthetic A 42 (AN1792) in patients with AD

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2435219

4 December 2018

Identifiers

10.1074/JBC.M700088200

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17545160%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17545160%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17545160%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

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