(Q36742412)

16 August 2017

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death (English)

1 reference

16 August 2017

1 reference

6

J W Shay

1 reference

16 August 2017

B Herbert

1

1 reference

16 August 2017

A E Pitts

2

1 reference

16 August 2017

S I Baker

3

1 reference

16 August 2017

S E Hamilton

4

1 reference

16 August 2017

W E Wright

5

1 reference

16 August 2017

D R Corey

7

1 reference

16 August 2017

language of work or name

English

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publication date

1 December 1999

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Proceedings of the National Academy of Sciences of the United States of America

16 August 2017

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16 August 2017

96

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16 August 2017

14276-14281

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16 August 2017

25

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Telomerase inhibition by peptide nucleic acids reverses 'immortality' of transformed human cells

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

An antisense oligonucleotide primer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

For better or worse? Telomerase inhibition and cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Creation of human tumour cells with defined genetic elements

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Telomerase and the maintenance of chromosome ends

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Cellular delivery of peptide nucleic acids and inhibition of human telomerase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Inhibition of human telomerase by 2'-O-methyl-RNA

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Essential role of mouse telomerase in highly proliferative organs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Extension of life-span by introduction of telomerase into normal human cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Controversies in the cellular pharmacology of oligodeoxynucleotides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: in vitro and in vivo studies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Telomerase and cancer: revisiting the telomere hypothesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

An alternative pathway for yeast telomere maintenance rescues est1- senescence

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Telomerase activity in human ovarian carcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Specific association of human telomerase activity with immortal cells and cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

TLC1: template RNA component of Saccharomyces cerevisiae telomerase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

The RNA component of human telomerase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Keeping the biotechnology of antisense in context.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

High telomerase activity in primary lung cancers: association with increased cell proliferation rates and advanced pathologic stage.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Runaway telomere elongation caused by telomerase RNA gene mutations

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=24427

Correlating telomerase activity levels with human neuroblastoma outcomes

5 September 2018

1 reference

12 December 2020

Development of Retinoblastoma in the Absence of Telomerase Activity

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12 December 2020

Telomerase activity in ordinary meningiomas predicts poor outcome

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12 December 2020

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1 reference

12 December 2020

Telomerase activity correlates with tumor aggressiveness and reflects therapy effect in breast cancer

1 reference

12 December 2020

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1 reference

12 December 2020

First "antisense" drug will treat CMV retinitis

1 reference

12 December 2020

Tetranucleotide GGGA motif in primary RNA transcripts. Novel target site for antisense design

1 reference

12 December 2020

Telomerase activity in preneoplastic and neoplastic gastric and colorectal lesions

1 reference

12 December 2020

Clinical implications of telomerase activity levels in acute leukemia

1 reference

12 December 2020

Mixed-backbone oligonucleotides as second-generation antisense agents with reduced phosphorothioate-related side effects

1 reference

12 December 2020

Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer

1 reference

12 December 2020

Automated synthesis of peptide nucleic acids and peptide nucleic acid-peptide conjugates

1 reference

12 December 2020

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1 reference

12 December 2020

Inhibition of human telomerase by a G-quadruplex-interactive compound

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.96.25.14276

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16 August 2017

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1 reference

16 August 2017

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