(Q36745332)

English

The anti-CD19 antibody-drug conjugate SAR3419 prevents hematolymphoid relapse postinduction therapy in preclinical models of pediatric acute lymphoblastic leukemia.

scientific article published on 20 February 2013

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scholarly article

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24 February 2020

The anti-CD19 antibody-drug conjugate SAR3419 prevents hematolymphoid relapse postinduction therapy in preclinical models of pediatric acute lymphoblastic leukemia (English)

1 reference

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24 February 2020

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Malcolm A Smith

6

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24 February 2020

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24 February 2020

Peter J. Houghton

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Peter J Houghton

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24 February 2020

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Ingrid Boehm

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24 February 2020

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Hernan Carol

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24 February 2020

Barbara Szymanska

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Barbara Szymanska

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24 February 2020

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Kathryn Evans

3

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24 February 2020

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20 February 2013

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24 February 2020

Clinical Cancer Research

1 reference

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24 February 2020

19

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24 February 2020

7

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24 February 2020

1795-1805

1 reference

Europe PubMed Central

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24 February 2020

Pharmacokinetic modeling of an induction regimen for in vivo combined testing of novel drugs against pediatric acute lymphoblastic leukemia xenografts.

1 reference

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Antibody therapy of cancer

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29 September 2017

Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children's oncology group

1 reference

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29 September 2017

SAR3419: an anti-CD19-Maytansinoid Immunoconjugate for the treatment of B-cell malignancies

1 reference

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29 September 2017

Biology, risk stratification, and therapy of pediatric acute leukemias: an update

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29 September 2017

Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618498

29 September 2017

Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618498

29 September 2017

Epidemiology of childhood cancer

1 reference

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29 September 2017

Antibody-maytansinoid conjugates designed to bypass multidrug resistance

1 reference

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Antibody-based therapy of leukaemia

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Eradication of CD19+ leukemia by targeted calicheamicin θ.

1 reference

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29 September 2017

Superior antitumor activity of SAR3419 to rituximab in xenograft models for non-Hodgkin's lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618498

29 September 2017

Potent antitumor activity of the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE against rituximab-sensitive and -resistant lymphomas

1 reference

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New insights into the early molecular events underlying B cell activation

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Targeted cancer therapy: conferring specificity to cytotoxic drugs

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29 September 2017

Monoclonal antibody-based therapeutics for leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618498

29 September 2017

GenePattern 2.0

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618498

29 September 2017

Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618498

29 September 2017

Recent developments in the maytansinoid antitumor agents

1 reference

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29 September 2017

Phase II clinical trial of bolus infusion anti-B4 blocked ricin immunoconjugate in patients with relapsed B-cell non-Hodgkin's lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618498

29 September 2017

Anti-B4-blocked ricin: a phase I trial of 7-day continuous infusion in patients with B-cell neoplasms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618498

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The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618498

28 June 2018

Phase I multidose-escalation study of the anti-CD19 maytansinoid immunoconjugate SAR3419 administered by intravenous infusion every 3 weeks to patients with relapsed/refractory B-cell lymphoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618498

5 September 2018

The pediatric preclinical testing program: description of models and early testing results.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618498

5 September 2018

Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing.

1 reference

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1 reference

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Phase I trial of anti-B4-blocked ricin in pediatric patients with leukemia and lymphoma

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23426279

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti-CD19 immunotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23426279

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based on heuristic

inferred from PubMed ID database lookup

Anti-B4-blocked ricin immunotoxin shows therapeutic efficacy in four different SCID mouse tumor models

1 reference

https://pubmed.ncbi.nlm.nih.gov/23426279

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23426279

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cure of multidrug-resistant human B-cell lymphoma xenografts by combinations of anti-B4-blocked ricin and chemotherapeutic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/23426279

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of human B-cell precursor leukemia in SCID mice by using a combination of the anti-CD19 immunotoxin B43-PAP with the standard chemotherapeutic drugs vincristine, methylprednisolone, and L-asparaginase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23426279

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based on heuristic

inferred from PubMed ID database lookup

Phase I studies of AVE9633, an anti-CD33 antibody-maytansinoid conjugate, in adult patients with relapsed/refractory acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23426279

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1078-0432.CCR-12-3613

1 reference

Europe PubMed Central

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24 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23426279%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23426279%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

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