(Q36745429)

16 August 2017

Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy (English)

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16 August 2017

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1 reference

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Feng Li

1

1 reference

16 August 2017

Jie Lu

2

1 reference

16 August 2017

Jie Cheng

3

1 reference

16 August 2017

Laiyou Wang

4

1 reference

16 August 2017

Tsutomu Matsubara

5

1 reference

16 August 2017

Iván L Csanaky

6

1 reference

16 August 2017

Curtis D Klaassen

7

1 reference

16 August 2017

Frank J Gonzalez

8

1 reference

16 August 2017

Xiaochao Ma

9

1 reference

16 August 2017

language of work or name

English

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publication date

10 March 2013

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16 August 2017

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16 August 2017

19

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16 August 2017

4

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16 August 2017

418-420

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Direct oxidation and covalent binding of isoniazid to rodent liver and human hepatic microsomes: humans are more like mice than rats

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

Liver disease and erythropoietic protoporphyria: a concise review.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

Liver disease in erythropoietic protoporphyria: insights and implications for management

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

Antituberculosis drugs and hepatotoxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

An official ATS statement: hepatotoxicity of antituberculosis therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

Induction of hepatic microsomal enzymes after brief administration of rifampicin in man

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

Isoniazid liver injury: clinical spectrum, pathology, and probable pathogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

Compendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

Potentiation of isoniazid-induced liver toxicity by rifampicin in a combinational therapy of antitubercular drugs (rifampicin, isoniazid and pyrazinamide) in Wistar rats: A toxicity profile study.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618537

Mitochondrial oxidative stress and permeability transition in isoniazid and rifampicin induced liver injury in mice

5 September 2018

1 reference

12 December 2020

Isoniazid, rifampin, and hepatotoxicity

1 reference

12 December 2020

Role of hydrazine in the mechanism of isoniazid hepatotoxicity in rabbits

1 reference

12 December 2020

[Clinical and pathological analysis of liver injury resulting from rifampin and isoniazid]

1 reference

12 December 2020

Slow N-acetyltransferase 2 genotype affects the incidence of isoniazid and rifampicin-induced hepatotoxicity

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.3104

1 reference

16 August 2017

1 reference

16 August 2017

PubMed publication ID

23475203

1 reference