(Q36750261)

16 August 2017

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title

Specific targeted antiviral therapy for hepatitis C. (English)

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16 August 2017

1

Mark S Sulkowski

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16 August 2017

publication date

1 March 2007

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Current gastroenterology reports

16 August 2017

published in

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16 August 2017

volume

9

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16 August 2017

issue

1

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16 August 2017

page(s)

5-13

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https://scigraph.springernature.com/pub.10.1007/s11894-008-0015-x

16 August 2017

exact match

0 references

cites work

Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bio

1 reference

12 December 2020

General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues

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12 December 2020

Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine.

1 reference

12 December 2020

SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells

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12 December 2020

In vitro studies of cross-resistance mutations against two hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061.

1 reference

12 December 2020

Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

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12 December 2020

Ribavirin Antagonizes the In Vitro Anti-Hepatitis C Virus Activity of 2'-C-Methylcytidine, the Active Component of Valopicitabine

1 reference

12 December 2020

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

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12 December 2020

VX-950, a Novel Hepatitis C Virus (HCV) NS3-4A Protease Inhibitor, Exhibits Potent Antiviral Activities in HCV Replicon Cells

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12 December 2020

Effect of ribavirin on intracellular and plasma pharmacokinetics of nucleoside reverse transcriptase inhibitors in patients with human immunodeficiency virus-hepatitis C virus coinfection: results of a randomized clinical study

1 reference

12 December 2020

In vitro selected Con1 subgenomic replicons resistant to 2'-C-methyl-cytidine or to R1479 show lack of cross resistance

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12 December 2020

The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site

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12 December 2020

The face of future hepatitis C antiviral drug development: recent biological and virologic advances and their translation to drug development and clinical practice

1 reference

12 December 2020

Hepatitis C virus internal ribosome entry site (IRES) stem loop IIId contains a phylogenetically conserved GGG triplet essential for translation and IRES folding

1 reference

12 December 2020

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

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12 December 2020

Complete replication of hepatitis C virus in cell culture

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12 December 2020

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

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12 December 2020

The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy

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12 December 2020

Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase Ib, placebo-controlled, randomized study

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12 December 2020

Ribavirin antagonizes the effect of azidothymidine on HIV replication

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12 December 2020

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

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12 December 2020

The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture

1 reference

12 December 2020

An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

1 reference

12 December 2020

10.1007/S11894-008-0015-X

Identifiers

DOI

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16 August 2017

1 reference