(Q36755072)

English

Distinct Activation Mechanisms of NF-κB Regulator Inhibitor of NF-κB Kinase (IKK) by Isoforms of the Cell Death Regulator Cellular FLICE-like Inhibitory Protein (cFLIP).

scientific article published on 10 February 2016

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scholarly article

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Europe PubMed Central

PMC publication ID

16 August 2017

Distinct Activation Mechanisms of NF-κB Regulator Inhibitor of NF-κB Kinase (IKK) by Isoforms of the Cell Death Regulator Cellular FLICE-like Inhibitory Protein (cFLIP). (English)

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Europe PubMed Central

PMC publication ID

16 August 2017

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author name string

Mehdi Baratchian

1

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Christopher A Davis

2

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Europe PubMed Central

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16 August 2017

Akira Shimizu

3

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

David Escors

4

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Claire Bagnéris

5

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Europe PubMed Central

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16 August 2017

Tracey Barrett

6

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16 August 2017

Mary K Collins

7

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16 August 2017

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publication date

10 February 2016

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Europe PubMed Central

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16 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

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16 August 2017

291

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Europe PubMed Central

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16 August 2017

14

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Europe PubMed Central

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16 August 2017

7608-7620

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Europe PubMed Central

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16 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4817188/fullTextXML

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NEMO is essential for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP K13-induced gene expression and protection against death receptor-induced cell death, and its N-terminal 251 residues are sufficient for this process.

1 reference

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NEMO inhibits programmed necrosis in an NFκB-independent manner by restraining RIP1.

1 reference

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Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-κB pathway independent of TRAF6, TAK1 and LUBAC.

1 reference

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Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy

1 reference

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cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

1 reference

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1 reference

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Kaposi's sarcoma-associated herpesvirus vFLIP and human T cell lymphotropic virus type 1 Tax oncogenic proteins activate IkappaB kinase subunit gamma by different mechanisms independent of the physiological cytokine-induced pathways

1 reference

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Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

1 reference

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1 reference

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Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

1 reference

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29 September 2017

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

1 reference

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CD95 stimulation results in the formation of a novel death effector domain protein-containing complex

1 reference

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Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome

1 reference

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In vitro activation of the IkappaB kinase complex by human T-cell leukemia virus type-1 Tax

1 reference

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Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB.

1 reference

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Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK

1 reference

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Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways

1 reference

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1 reference

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1 reference

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Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail

1 reference

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c-FLIPR, a new regulator of death receptor-induced apoptosis.

1 reference

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KSHV vFLIP is essential for the survival of infected lymphoma cells

1 reference

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29 September 2017

N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

1 reference

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

1 reference

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The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817188

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FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817188

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NF-kappaB signals induce the expression of c-FLIP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817188

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

1 reference

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The essential role of MEKK3 in TNF-induced NF-kappaB activation

1 reference

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1 reference

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1 reference

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Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK.

1 reference

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The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

1 reference

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1 reference

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1 reference

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1 reference

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Characterization of a mutant cell line that does not activate NF-kappaB in response to multiple stimuli

1 reference

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1 reference

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Activation of NF-kappaB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817188

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Formation of the death domain complex between FADD and RIP1 proteins in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817188

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FLIP-mediated autophagy regulation in cell death control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817188

5 September 2018

The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817188

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817188

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Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells.

1 reference

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cFLIP expression correlates with tumour progression and patient outcome in non-Hodgkin lymphomas of low grade of malignancy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M116.718122

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Overexpression of FLIPL is an independent marker of poor prognosis in colorectal cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/26865630

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Flip protein expression in Burkitt's lymphomas is associated with a poor clinical outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/26865630

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M116.718122

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

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