(Q36759557)

16 August 2017

The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity (English)

1 reference

16 August 2017

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1 reference

7

Eva-Maria Mandelkow

0 references

Eckhard Mandelkow

6

object named as

Eckhard Mandelkow

1 reference

16 August 2017

Jochen Martin Decker

1

1 reference

16 August 2017

Lars Krüger

2

1 reference

16 August 2017

Astrid Sydow

3

1 reference

16 August 2017

Frank Ja Dennissen

4

1 reference

16 August 2017

Zuzana Siskova

5

1 reference

16 August 2017

language of work or name

1 reference

1 March 2016

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16 August 2017

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16 August 2017

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4

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16 August 2017

552-569

1 reference

describes a project that uses

16 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4818782/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice

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Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.

29 September 2017

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Overactivation of NR2B-containing NMDA receptors through entorhinal-hippocampal connection initiates accumulation of hyperphosphorylated tau in rat hippocampus after transient middle cerebral artery occlusion

29 September 2017

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Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation

29 September 2017

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Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome.

29 September 2017

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P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway

29 September 2017

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Seizure resistance without parkinsonism in aged mice after tau reduction

29 September 2017

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Extrasynaptic NMDA receptor involvement in central nervous system disorders

29 September 2017

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Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells

29 September 2017

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Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model

29 September 2017

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A protocol for construction of gene targeting vectors and generation of homologous recombinant embryonic stem cells.

29 September 2017

1 reference

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Seizures and epileptiform activity in the early stages of Alzheimer disease

29 September 2017

1 reference

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Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

29 September 2017

1 reference

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NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

29 September 2017

1 reference

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Neurodegenerative disease phenotypes in carriers of MAPT p.A152T, a risk factor for frontotemporal dementia spectrum disorders and Alzheimer disease

29 September 2017

1 reference

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Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.

29 September 2017

1 reference

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Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation

29 September 2017

1 reference

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The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Neurosteroid modulation of N-methyl-D-aspartate receptors: molecular mechanism and behavioral effects

29 September 2017

1 reference

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29 September 2017

The many faces of tau

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Degenerating synaptic boutons in prion disease: microglia activation without synaptic stripping

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Primer3Plus, an enhanced web interface to Primer3

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Cell signaling and neuronal death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Common molecular mechanisms in explicit and implicit memory

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Role of distinct NMDA receptor subtypes at central synapses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia tau mutation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Disruption of CREB function in brain leads to neurodegeneration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Morphological changes in dendritic spines associated with long-term synaptic plasticity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

NMDA receptor subunits: diversity, development and disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Analysis of thick brain sections by obverse—Reverse computer microscopy: Application of a new, high clarity Golgi—Nissl stain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

The distribution of tau in the mammalian central nervous system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

A new generation of Ca2+ indicators with greatly improved fluorescence properties

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Neuropathological stageing of Alzheimer-related changes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

A simple method for organotypic cultures of nervous tissue

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Diversity and fluctuation of spine morphology in CA1 pyramidal neurons after transient global ischemia

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Subunit-specific NMDA receptor trafficking to synapses

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Abnormal glutamate transport function in mutant amyloid precursor protein transgenic mice

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Both adult and juvenile tau microtubule-associated proteins are axon specific in the developing and adult rat cerebellum

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Mapping patterns of c-fos expression in the central nervous system after seizure

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer's disease.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Engineering a memory with LTD and LTP.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Induction of sharp wave-ripple complexes in vitro and reorganization of hippocampal networks

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Tau mutations cause frontotemporal dementias

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4818782

Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26931569

12 December 2020

inferred from PubMed ID database lookup

A peculiar constellation of tau pathology defines a subset of dementia in the elderly

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26931569

12 December 2020

inferred from PubMed ID database lookup

Seizures in progressive supranuclear palsy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26931569

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.15252/EMBR.201541439

1 reference

16 August 2017

1 reference

16 August 2017

PubMed publication ID

26931569

1 reference