(Q51019667)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21325519%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

title

Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant (English)

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22 January 2020

1 reference

2

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22 January 2020

Tariq Ahmed

4

1 reference

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22 January 2020

13

Eva-Maria Mandelkow

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22 January 2020

author name string

Astrid Sydow

1

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22 January 2020

Fang Zheng

3

1 reference

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22 January 2020

Detlef Balschun

5

1 reference

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22 January 2020

Olga Petrova

6

1 reference

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22 January 2020

Dagmar Drexler

7

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22 January 2020

Lepu Zhou

8

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22 January 2020

Gabriele Rune

9

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22 January 2020

Rudi D'Hooge

11

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22 January 2020

Christian Alzheimer

12

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22 January 2020

Eckhard Mandelkow

10

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22 January 2020

language of work or name

English

0 references

publication date

1 February 2011

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22 January 2020

published in

Journal of Neuroscience

1 reference

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22 January 2020

volume

31

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22 January 2020

page(s)

2511-2525

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22 January 2020

issue

7

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Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning.

22 January 2020

cites work

1 reference

12 December 2020

Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease

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12 December 2020

Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies.

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12 December 2020

Precisely localized LTD in the neocortex revealed by infrared-guided laser stimulation

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12 December 2020

Deletion of the ryanodine receptor type 3 (RyR3) impairs forms of synaptic plasticity and spatial learning

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12 December 2020

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

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12 December 2020

Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein

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12 December 2020

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

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12 December 2020

Structural and functional differences between 3-repeat and 4-repeat tau isoforms. Implications for normal tau function and the onset of neurodegenetative disease

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12 December 2020

Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias

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12 December 2020

Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice.

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12 December 2020

Neurodegenerative tauopathies

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12 December 2020

Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure

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12 December 2020

The molecular biology of memory storage: a dialogue between genes and synapses

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12 December 2020

Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.

1 reference

12 December 2020

Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.

1 reference

12 December 2020

Studying gene function in eukaryotes by conditional gene inactivation

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12 December 2020

Synaptic plasticity in animal models of early Alzheimer's disease

1 reference

12 December 2020

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

12 December 2020

Automatic recognition of explorative strategies in the Morris water maze

1 reference

12 December 2020

Median raphe mediates estrogenic effects to the hippocampus in female rats

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12 December 2020

NMDA receptors, place cells and hippocampal spatial memory

1 reference

12 December 2020

Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy.

1 reference

12 December 2020

Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain.

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12 December 2020

Hippocampal synapses depend on hippocampal estrogen synthesis.

1 reference

12 December 2020

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

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12 December 2020

1 reference

12 December 2020

Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice

1 reference

12 December 2020

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

1 reference

12 December 2020

Patterns of memory impairment and perseverative behavior discriminate early Alzheimer's disease from subcortical vascular dementia.

1 reference

12 December 2020

Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis

1 reference

12 December 2020

Tau suppression in a neurodegenerative mouse model improves memory function

1 reference

12 December 2020

1 reference

12 December 2020

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs

1 reference

12 December 2020

Synaptic plasticity at hippocampal mossy fibre synapses

1 reference

12 December 2020

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).

1 reference

12 December 2020

Rapamycin alleviates toxicity of different aggregate-prone proteins

1 reference

12 December 2020

A decade of modeling Alzheimer's disease in transgenic mice.

1 reference

12 December 2020

Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections

1 reference

12 December 2020

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits

1 reference

12 December 2020

Learning induces long-term potentiation in the hippocampus

1 reference

12 December 2020

The DeltaK280 mutation in MAP tau favors exon 10 skipping in vivo.

1 reference

12 December 2020

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

1 reference

12 December 2020

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

1 reference

12 December 2020

Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1.

1 reference

12 December 2020

Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.

1 reference

12 December 2020

Knock-out and transgenic mouse models of tauopathies.

1 reference

12 December 2020

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

1 reference

12 December 2020

Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells

1 reference

12 December 2020

The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy

1 reference

12 December 2020

Beyond amyloid: the next generation of Alzheimer's disease therapeutics.

1 reference

12 December 2020

Interaction of tau protein with the dynactin complex

1 reference

12 December 2020

Perseveration in Alzheimer's disease

1 reference

12 December 2020

The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

1 reference

12 December 2020

In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons

1 reference

12 December 2020

Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning

1 reference

12 December 2020

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

1 reference

12 December 2020

Frequency facilitation at mossy fiber-CA3 synapses of freely behaving rats is regulated by adenosine A1 receptors.

1 reference

12 December 2020

A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics.

1 reference

12 December 2020

Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone.

1 reference

12 December 2020

Animal models of Alzheimer's disease and frontotemporal dementia

1 reference

12 December 2020

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

12 December 2020

Tau-based treatment strategies in neurodegenerative diseases

1 reference

12 December 2020

Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease

1 reference

12 December 2020

Relevance of transgenic mouse models to human Alzheimer disease

1 reference

12 December 2020

Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis

1 reference

12 December 2020

Activity-dependent dynamic microtubule invasion of dendritic spines

1 reference

12 December 2020

Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration

1 reference

12 December 2020

Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity

1 reference

12 December 2020

The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.

1 reference

12 December 2020

Inhibition of tau polymerization with a cyanine dye in two distinct model systems

1 reference

12 December 2020

Transmission and spreading of tauopathy in transgenic mouse brain

1 reference

12 December 2020

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

1 reference

12 December 2020

Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology

1 reference

12 December 2020

Control of neuronal polarity and plasticity--a renaissance for microtubules?

1 reference

12 December 2020

Alzheimer's disease: old problem, new views from transgenic and viral models

1 reference

12 December 2020

Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines

1 reference

12 December 2020

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

1 reference

12 December 2020

Hippocampus, amygdala, and memory deficits in rats.

1 reference

12 December 2020

Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA.

1 reference

12 December 2020

Short-term synaptic plasticity

1 reference

12 December 2020

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform

1 reference

12 December 2020

Domains of tau protein and interactions with microtubules

1 reference

12 December 2020

Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau.

1 reference

12 December 2020

Control of memory formation through regulated expression of a CaMKII transgene

1 reference

12 December 2020

RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

1 reference

12 December 2020

Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain

1 reference

12 December 2020

The 'jaws' model of tau-microtubule interaction examined in CHO cells

1 reference

12 December 2020

Effects of GABA(A) inhibition on the expression of long-term potentiation in CA1 pyramidal cells are dependent on tetanization parameters

1 reference

12 December 2020

When are class I metabotropic glutamate receptors necessary for long-term potentiation?

1 reference

12 December 2020

10.1523/JNEUROSCI.5245-10.2011

Identifiers

DOI

1 reference

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release_iarieunzbzas3okp6xt2pgj53i

22 January 2020

Fatcat ID

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Fatcat

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24 November 2022

mapped directly with Wikidata item

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22 January 2020

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