(Q37196122)

18 August 2017

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title

Animal models of Alzheimer's disease and frontotemporal dementia (English)

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18 August 2017

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frontotemporal dementia

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2

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18 August 2017

Jürgen Götz

1

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language of work or name

English

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publication date

1 July 2008

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Nature Reviews Neuroscience

18 August 2017

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18 August 2017

9

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18 August 2017

7

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18 August 2017

532-544

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https://scigraph.springernature.com/pub.10.1038/nrn2420

18 August 2017

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31 March 2020

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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

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31 March 2020

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31 March 2020

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31 March 2020

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Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease

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Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology.

31 March 2020

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BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

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Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

31 March 2020

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beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice

31 March 2020

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Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.

31 March 2020

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A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

31 March 2020

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Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

31 March 2020

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Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease

31 March 2020

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Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease

31 March 2020

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Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

31 March 2020

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The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

31 March 2020

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31 March 2020

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Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

31 March 2020

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Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

31 March 2020

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Differential regulation of dynein and kinesin motor proteins by tau

31 March 2020

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Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

31 March 2020

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Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

31 March 2020

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A century of Alzheimer's disease

31 March 2020

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Interaction of tau protein with the dynactin complex

31 March 2020

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Dying for a cause: invertebrate genetics takes on human neurodegeneration

31 March 2020

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Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

31 March 2020

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Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

31 March 2020

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Oxidative stress mediates tau-induced neurodegeneration in Drosophila

31 March 2020

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Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity

31 March 2020

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TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.

31 March 2020

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beta-Amyloid induces paired helical filament-like tau filaments in tissue culture

31 March 2020

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Tau phosphorylation sites work in concert to promote neurotoxicity in vivo

31 March 2020

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Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.

31 March 2020

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The role of presenilin cofactors in the gamma-secretase complex

31 March 2020

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Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype

31 March 2020

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

31 March 2020

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Conformational Abs recognizing a generic amyloid fibril epitope

31 March 2020

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Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils

31 March 2020

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Family-based association between Alzheimer's disease and variants in UBQLN1

31 March 2020

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Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes

31 March 2020

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Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease

31 March 2020

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Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity

31 March 2020

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Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila

31 March 2020

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Modelling neurodegenerative diseases in Drosophila: a fruitful approach?

31 March 2020

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Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.

31 March 2020

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Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy

31 March 2020

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Progressive neurodegeneration in C. elegans model of tauopathy

31 March 2020

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Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

31 March 2020

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SUT-1 enables tau-induced neurotoxicity in C. elegans

31 March 2020

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

31 March 2020

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Genetics of egg-laying in worms.

31 March 2020

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Presenilin function in Caenorhabditis elegans

31 March 2020

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Screening for presenilin inhibitors using the free-living nematode, Caenorhabditis elegans.

31 March 2020

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Functional Genomics meets neurodegenerative disorders Part I: transcriptomic and proteomic technology

31 March 2020

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Functional Genomics meets neurodegenerative disorders. Part II: application and data integration

31 March 2020

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Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

31 March 2020

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Transcriptional profiling reveals strict boundaries between hippocampal subregions

31 March 2020

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Regional and strain-specific gene expression mapping in the adult mouse brain

31 March 2020

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Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei

31 March 2020

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

31 March 2020

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Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

31 March 2020

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Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice

31 March 2020

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Mitochondrial oxidative stress causes hyperphosphorylation of tau.

31 March 2020

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ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

31 March 2020

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Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition.

31 March 2020

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Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling.

31 March 2020

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Gene expression profiling of the tau mutant (P301L) transgenic mouse brain

31 March 2020

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Tau filament formation in transgenic mice expressing P301L tau.

31 March 2020

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Role for glyoxalase I in Alzheimer's disease.

31 March 2020

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Beta-amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes

31 March 2020

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A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration

31 March 2020

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Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice.

31 March 2020

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Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice

31 March 2020

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Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without Apolipoprotein E.

31 March 2020

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In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease

31 March 2020

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Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B

31 March 2020

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Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice

31 March 2020

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Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain.

31 March 2020

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Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography

31 March 2020

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19F and 1H MRI detection of amyloid beta plaques in vivo

31 March 2020

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Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy

31 March 2020

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Drug discovery in dementia: the role of rodent models

31 March 2020

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Antibody-based approaches in Alzheimer's research: safety, pharmacokinetics, metabolism, and analytical tools

31 March 2020

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

31 March 2020

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

31 March 2020

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Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles

31 March 2020

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Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

31 March 2020

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Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.

31 March 2020

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Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

31 March 2020

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Active immunization trial in Abeta42-injected P301L tau transgenic mice.

31 March 2020

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Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

31 March 2020

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Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice

31 March 2020

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Tau is essential to beta -amyloid-induced neurotoxicity

31 March 2020

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Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models

31 March 2020

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Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease

31 March 2020

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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

31 March 2020

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Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.

31 March 2020

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A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model.

31 March 2020

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Perinatal omega-3 polyunsaturated fatty acid supply modifies brain zinc homeostasis during adulthood

31 March 2020

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Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease

31 March 2020

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Transgenic potato expressing Abeta reduce Abeta burden in Alzheimer's disease mouse model

31 March 2020

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Mechanisms of disease: new therapeutic strategies for Alzheimer's disease--targeting APP processing in lipid rafts

31 March 2020

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Neurodegenerative diseases and oxidative stress

31 March 2020

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M1 receptors play a central role in modulating AD-like pathology in transgenic mice

31 March 2020

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Calpain inhibitors: a treatment for Alzheimer's disease

31 March 2020

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Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

31 March 2020

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Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles

31 March 2020

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Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.

31 March 2020

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

31 March 2020

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

31 March 2020

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Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

31 March 2020

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Abeta40 protects non-toxic Abeta42 monomer from aggregation

31 March 2020

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

31 March 2020

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Reconstitution of gamma-secretase activity

31 March 2020

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Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

31 March 2020

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The H1c haplotype at the MAPT locus is associated with Alzheimer's disease.

31 March 2020

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Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

31 March 2020

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A specific amyloid-beta protein assembly in the brain impairs memory

31 March 2020

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

31 March 2020

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Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

31 March 2020

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Control of peripheral nerve myelination by the beta-secretase BACE1

31 March 2020

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The effects of a neuregulin 1 variant on white matter density and integrity

31 March 2020

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Alzheimer disease: BACE1 branches out.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRN2420

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PubMed ID

18568014

Dimensions Publication ID

18 August 2017

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1 reference

PubMed ID

18568014