(Q36642054)

15 August 2017

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title

Drug discovery in dementia: the role of rodent models (English)

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15 August 2017

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Debby Van Dam

1

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PubMed ID

17080031

15 August 2017

Peter Paul De Deyn

series ordinal

2

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15 August 2017

1 November 2006

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Nature Reviews Drug Discovery

15 August 2017

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15 August 2017

5

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15 August 2017

956-970

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15 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrd2075

15 August 2017

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cites work

The magnitude of dementia occurrence in the world

1 reference

The canine as an animal model of human aging and dementia

31 March 2020

1 reference

Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats.

31 March 2020

1 reference

Senile plaques and other senile changes in the brain of an aged American black bear

31 March 2020

1 reference

Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat.

31 March 2020

1 reference

beta-Amyloid (A beta) deposition in the brains of aged orangutans.

31 March 2020

1 reference

Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease

31 March 2020

1 reference

The neurobiology of memory changes in normal aging

31 March 2020

1 reference

Pre- and post-synaptic cholinergic dysfunction in aged rodent brain regions: new findings and an interpretative review

31 March 2020

1 reference

The senescence-accelerated prone mouse (SAMP8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease

31 March 2020

1 reference

Scopolamine model of dementia: electroencephalogram findings and cognitive performance.

31 March 2020

1 reference

Lesions and dysfunctions of the nucleus basalis as Alzheimer's disease models: general and critical overview and analysis of the long-term changes in several excitotoxic models

31 March 2020

1 reference

Comparison between the behavioural effects of septal and hippocampal lesions: a review

31 March 2020

1 reference

On the role of the hippocampus in learning and memory in the rat.

31 March 2020

1 reference

Double dissociation between hippocampal and prefrontal lesions on an operant delayed matching task and a water maze reference memory task.

31 March 2020

1 reference

beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis

31 March 2020

1 reference

Beta-amyloid(Phe(SO3H)24)25-35 in rat nucleus basalis induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation.

31 March 2020

1 reference

Implanted cannula-mediated repetitive administration of Abeta25-35 into the mouse cerebral ventricle effectively impairs spatial working memory.

31 March 2020

1 reference

Progressive brain dysfunction following intracerebroventricular infusion of beta(1-42)-amyloid peptide

31 March 2020

1 reference

Memory impairment induced by chronic intracerebroventricular infusion of beta-amyloid (1-40) involves downregulation of protein kinase C.

31 March 2020

1 reference

Reduction in somatostatin and substance P levels and choline acetyltransferase activity in the cortex and hippocampus of the rat after chronic intracerebroventricular infusion of beta-amyloid (1-40).

31 March 2020

1 reference

The cause of neuronal degeneration in Alzheimer's disease

31 March 2020

1 reference

Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease

31 March 2020

1 reference

The toxicity of tumor necrosis factor-α upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for alzheimer's disease

31 March 2020

1 reference

Modeling mitochondrial function in aging neurons

31 March 2020

1 reference

Local action of the diabetogenic drug, streptozotocin, on glucose and energy metabolism in rat brain cortex

31 March 2020

1 reference

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

31 March 2020

1 reference

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

31 March 2020

1 reference

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

31 March 2020

1 reference

A decade of modeling Alzheimer's disease in transgenic mice.

31 March 2020

1 reference

Characterization of transgenic mice expressing apolipoprotein E4(C112R) and apolipoprotein E4(L28P; C112R).

31 March 2020

1 reference

Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice.

31 March 2020

1 reference

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

31 March 2020

1 reference

Metabolic regulation of brain Abeta by neprilysin.

31 March 2020

1 reference

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

31 March 2020

1 reference

Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models

31 March 2020

1 reference

Characterization of a double (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation

31 March 2020

1 reference

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

31 March 2020

1 reference

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

31 March 2020

1 reference

Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice

31 March 2020

1 reference

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

31 March 2020

1 reference

Animal cognition: defining the issues

31 March 2020

1 reference

Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat.

31 March 2020

1 reference

Free operant and discrete trial performance of mice in the nine-hole box apparatus: validation using amphetamine and scopolamine

31 March 2020

1 reference

Applications of the Morris water maze in the study of learning and memory

31 March 2020

1 reference

The Morris water-escape task in mice: strain differences and effects of intra-maze contrast and brightness.

31 March 2020

1 reference

Effect of Morris water maze diameter on visual-spatial learning in different mouse strains

31 March 2020

1 reference

Standardizing tests of mouse behavior: reasons, recommendations, and reality

31 March 2020

1 reference

The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats

31 March 2020

1 reference

FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats.

31 March 2020

1 reference

Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models

31 March 2020

1 reference

A randomized trial of risperidone, placebo, and haloperidol for behavioral symptoms of dementia.

31 March 2020

1 reference

Management of agitation, aggression, and psychosis associated with dementia: a pooled analysis including three randomized, placebo-controlled double-blind trials in nursing home residents treated with risperidone

31 March 2020

1 reference

Acute and subchronic effects of tiapride on isolation-induced aggression in male mice

31 March 2020

1 reference

Learned helplessness: validity and reliability of depressive-like states in mice.

31 March 2020

1 reference

Reduced sensitivity to sucrose in rats bred for helplessness: a study using the matching law.

31 March 2020

1 reference

Immunotherapy for Alzheimer's disease

31 March 2020

1 reference

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

31 March 2020

1 reference

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

31 March 2020

1 reference

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

31 March 2020

1 reference

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

31 March 2020

1 reference

Searching for the role and the most suitable biomarkers of oxidative stress in Alzheimer's disease and in other neurodegenerative diseases.

31 March 2020

1 reference

Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease.

31 March 2020

1 reference

Inflammatory processes in Alzheimer's disease

31 March 2020

1 reference

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

31 March 2020

1 reference

Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment.

31 March 2020

1 reference

Cognitive evaluation of disease-modifying efficacy of galantamine and memantine in the APP23 model

31 March 2020

1 reference

Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model.

31 March 2020

1 reference

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

31 March 2020

1 reference

Immunotherapeutic Approaches to Alzheimer's Disease

31 March 2020

1 reference

Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice.

31 March 2020

1 reference

The pharmacogenomics of Alzheimer's disease

31 March 2020

1 reference

Neuropsychiatric symptoms of dementia: cross-sectional analysis from a prospective, longitudinal Belgian study.

31 March 2020

1 reference

Molecular genetics of Alzheimer's disease.

31 March 2020

1 reference

Presenilin function and gamma-secretase activity

31 March 2020

1 reference

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

31 March 2020

1 reference

Oxidative stress and neurodegeneration

31 March 2020

1 reference

Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain

31 March 2020

1 reference

Inflammation and Alzheimer's disease

31 March 2020

1 reference

A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study.

31 March 2020

1 reference

Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study

31 March 2020

1 reference

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

31 March 2020

1 reference

Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease

31 March 2020

1 reference

Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol.

31 March 2020

1 reference

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

31 March 2020

1 reference

A focus on the synapse for neuroprotection in Alzheimer disease and other dementias

31 March 2020

1 reference

Differences in the immune response to long term Abeta vaccination in C57BL/6 and B6D2F1 mice.

31 March 2020

1 reference

Age-dependent cognitive decline in the APP23 model precedes amyloid deposition.

31 March 2020

1 reference

Distribution, progression and chemical composition of cortical amyloid-beta deposits in aged rhesus monkeys: similarities to the human.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Remembrance of odors past: enhancement by central facilitation of AMPA receptors.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD2075

1 reference

15 August 2017

1 reference

PubMed ID

17080031