(Q36109130)

12 August 2017

1 reference

title

Presenilin function and gamma-secretase activity (English)

1 reference

12 August 2017

Brunkan AL

1

1 reference

PubMed ID

15857382

12 August 2017

Goate AM

series ordinal

2

1 reference

PubMed ID

15857382

12 August 2017

language of work or name

English

0 references

publication date

1 May 2005

1 reference

Journal of Neurochemistry

12 August 2017

1 reference

12 August 2017

93

1 reference

12 August 2017

769-792

1 reference

12 August 2017

4

1 reference

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

12 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Distinct processing of endogenous and overexpressed recombinant presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Regional and cellular localization of presenilin-2 RNA in rat and human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Homodimerization of presenilin N-terminal fragments is affected by mutations linked to Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Nicastrin binds to membrane-tethered Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Membrane topology of gamma-secretase component PEN-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Alzheimer's disease-associated presenilin 1 in neuronal cells: evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The presenilins turned inside out: implications for their structures and functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Mice lacking both presenilin genes exhibit early embryonic patterning defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Novel class of polytopic proteins with domains associated with putative protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Mutations in APP have independent effects on Abeta and CTFgamma generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Signalling downstream of activated mammalian Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Contribution of presenilin/gamma-secretase to calsenilin-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Evidence for a six-transmembrane domain structure of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Calsenilin reverses presenilin-mediated enhancement of calcium signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilins are processed by caspase-type proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The Notch1 receptor is cleaved constitutively by a furin-like convertase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Drosophila nicastrin is essential for the intramembranous cleavage of notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Selective inhibition of Abeta42 production by NSAID R-enantiomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Immunohistochemical analysis of presenilin-1 expression in the mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Direct association of presenilin-1 with beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Notch-1 activation by familial Alzheimer's disease (FAD)-linked mutant forms of presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Effects of PS1 deficiency on membrane protein trafficking in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin affects arm/beta-catenin localization and function in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Mutant presenilin 1 increases the levels of Alzheimer amyloid beta-peptide Abeta42 in late compartments of the constitutive secretory pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Identification of a novel family of presenilin homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Alzheimer disease PS-1 exon 9 deletion defined.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Activated Notch1 associates with a presenilin‐1/γ‐secretase docking site

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Calcium depletion dissociates and activates heterodimeric notch receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Evidence for a physical interaction between presenilin and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Mutational analysis of intrinsic regions of presenilin 2 that determine its endoproteolytic cleavage and pathological function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Gamma-secretase activity is associated with a conformational change of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The role of Alzheimer's disease-related presenilin 1 in intercellular adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Risk of Alzheimer's disease and duration of NSAID use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Biochemical and immunocytochemical characterization of calsenilin in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03099.X

10.1111/J.1471-4159.2005.03099.X

21 January 2018

Identifiers

DOI

1 reference

12 August 2017

1 reference

PubMed ID

15857382