(Q34649271)

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Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

electrophoresis

0 references

object named as

Michael T Ryan

3

0 references

Nicholas A. Williamson

object named as

Nicholas A Williamson

6

0 references

Colin L. Masters

8

object named as

Colin L Masters

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Catriona A. McLean

7

object named as

Catriona A McLean

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Janetta G Culvenor

1

object named as

Janetta G Culvenor

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

author name string

Nancy T Ilaya

2

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Louise Canterford

4

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

David E Hoke

5

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Geneviève Evin

9

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

language of work or name

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publication date

1 January 2004

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

271

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

375-385

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Identification of a novel family of presenilin homologues

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Binding partners of Alzheimer's disease proteins: are they physiologically relevant?

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Membrane topology of gamma-secretase component PEN-2.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Oligodendrocytes from neural stem cells express alpha-synuclein: increased numbers from presenilin 1 deficient mice.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Variable phenotype of Alzheimer's disease with spastic paraparesis.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Alternative transcripts of presenilin-1 associated with frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Familial Alzheimer's disease-associated mutations block translocation of full-length presenilin 1 to the nuclear envelope

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2003.03936.X

21 January 2018

Identifiers

10.1046/J.1432-1033.2003.03936.X

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

ResearchGate publication ID

0 references

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