(Q53415286)

14 May 2018

title

Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells. (English)

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14 May 2018

author name string

Palacino JJ

1

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14 May 2018

Berechid BE

2

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14 May 2018

Alexander P

3

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14 May 2018

Eckman C

4

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14 May 2018

Younkin S

5

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14 May 2018

Nye JS

6

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14 May 2018

Wolozin B

7

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14 May 2018

language of work or name

English

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publication date

1 January 2000

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14 May 2018

Journal of Biological Chemistry

published in

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14 May 2018

volume

275

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14 May 2018

issue

1

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14 May 2018

page(s)

215-222

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14 May 2018

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Cleavage of amyloid beta peptide during constitutive processing of its precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Regulation of APP processing by intra- and intercellular signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Effects of PS1 deficiency on membrane protein trafficking in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Lack of requirement for presenilin1 in Notch1 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Direct association of presenilin-1 with beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

Regulation of apoptosis by presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.1.215

21 January 2018

Identifiers

DOI

10.1074/JBC.275.1.215

1 reference

14 May 2018

1 reference

14 May 2018