(Q40541170)

English

Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins

scientific article published on 25 June 2004

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scholarly article

1 reference

Europe PubMed Central

21 September 2017

Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins (English)

1 reference

Europe PubMed Central

21 September 2017

author name string

Sara Cervantes

1

1 reference

Europe PubMed Central

21 September 2017

Carlos A Saura

2

1 reference

Europe PubMed Central

21 September 2017

Esther Pomares

3

1 reference

Europe PubMed Central

21 September 2017

Roser Gonzàlez-Duarte

4

1 reference

Europe PubMed Central

21 September 2017

Gemma Marfany

5

1 reference

Europe PubMed Central

21 September 2017

language of work or name

0 references

publication date

25 June 2004

1 reference

Europe PubMed Central

21 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

21 September 2017

279

1 reference

Europe PubMed Central

21 September 2017

35

1 reference

Europe PubMed Central

21 September 2017

36519-36529

1 reference

Europe PubMed Central

21 September 2017

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Notch receptor cleavage depends on but is not directly executed by presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Homodimerization of presenilin N-terminal fragments is affected by mutations linked to Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

A genetic system based on split-ubiquitin for the analysis of interactions between membrane proteins in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Effect of site-directed mutagenesis on conserved positions of Drosophila alcohol dehydrogenase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Nuclear access and action of notch in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

A sensitive and quantitative assay for measuring cleavage of presenilin substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Accumulation of beta-amyloid fibrils in pancreas of transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Elucidation of the interactions between C99, presenilin, and nicastrin by the split-ubiquitin assay

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Activated Notch1 associates with a presenilin‐1/γ‐secretase docking site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Biochemistry. Intramembrane proteases--mixing oil and water

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404832200

21 January 2018

Identifiers

10.1074/JBC.M404832200

1 reference

Europe PubMed Central

21 September 2017

1 reference

Europe PubMed Central

21 September 2017

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