(Q53234760)

English

Mutant presenilin 1 increases the levels of Alzheimer amyloid beta-peptide Abeta42 in late compartments of the constitutive secretory pathway.

scientific article published in May 2000

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/10800930

Mutant presenilin 1 increases the levels of Alzheimer amyloid beta-peptide Abeta42 in late compartments of the constitutive secretory pathway. (English)

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/10800930

Frédéric Checler

3

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/10800930

author name string

Petanceska SS

1

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/10800930

Seeger M

2

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/10800930

Gandy S

4

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/10800930

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publication date

1 May 2000

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/10800930

Journal of Neurochemistry

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/10800930

74

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/10800930

5

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/10800930

1878-1884

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/10800930

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

1 reference

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21 January 2018

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

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21 January 2018

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Neurohormonal Signaling Pathways and the Regulation of Alzheimer beta-Amyloid Precursor Metabolism

1 reference

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21 January 2018

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Alzheimer's disease. In search of gamma-secretase.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Transport of an external Lys-Asp-Glu-Leu (KDEL) protein from the plasma membrane to the endoplasmic reticulum: studies with cholera toxin in Vero cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Localization and possible functions of presenilins in brain

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Increased Abeta42(43) from cell lines expressing presenilin 1 mutations.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Mutant genes in familial Alzheimer's disease and transgenic models

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Introduction: Notch signalling and choice of cell fates in development.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

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21 January 2018

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741878.X

21 January 2018

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

1 reference

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21 January 2018

Identifiers

10.1046/J.1471-4159.2000.0741878.X

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/10800930

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/10800930

ResearchGate publication ID

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